Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Simone L. Baerentzen"'
Autor:
Vladimir Shalgunov, Mengfei Xiong, Elina T. L’Estrade, Nakul R. Raval, Ida V. Andersen, Fraser G. Edgar, Nikolaj R. Speth, Simone L. Baerentzen, Hanne D. Hansen, Lene L. Donovan, Arafat Nasser, Siv T. Peitersen, Andreas Kjaer, Gitte M. Knudsen, Stina Syvänen, Mikael Palner, Matthias M. Herth
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Background Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessib
Externí odkaz:
https://doaj.org/article/abd4cf9642dc46f89d08c15d1cabc529
Autor:
Elina Tampio L’Estrade, Fraser G. Edgar, Mengfei Xiong, Vladimir Shalgunov, Simone L. Baerentzen, Maria Erlandsson, Tomas G. Ohlsson, Mikael Palner, Gitte M. Knudsen, Matthias M. Herth
Publikováno v:
ACS Omega, Vol 4, Iss 4, Pp 7344-7353 (2019)
Externí odkaz:
https://doaj.org/article/a2f7493d2aa241d4aaf74d2a67c30505
Autor:
Anne M. Landau, Majken B. Thomsen, Heidi Kaastrup Müller, Jan Jacobsen, Dariusz Orlowski, Aage Kristian Olsen Alstrup, Thea P. Lillethorup, Simone L. Baerentzen, Ove Noer, Betina Elfving, Anna C. Schacht, David J. Brooks
Publikováno v:
Thomsen, M B, Schacht, A C, Alstrup, A K O, Jacobsen, J, Lillethorup, T P, Bærentzen, S L, Noer, O, Orlowski, D, Elfving, B, Müller, H K, Brooks, D J & Landau, A M 2020, ' Preclinical PET Studies of [ 11 C]UCB-J Binding in Minipig Brain ', Molecular Imaging and Biology, vol. 22, no. 5, pp. 1290-1300 . https://doi.org/10.1007/s11307-020-01506-8
PURPOSE: Loss of neuronal synapse function is associated with a number of brain disorders. The [11C]UCB-J positron emission tomography (PET) tracer allows for in vivo examination of synaptic density, as it binds to synaptic vesicle glycoprotein 2A (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4692ef3bc0973db1969e21b8c07830ca
https://doi.org/10.1007/s11307-020-01506-8
https://doi.org/10.1007/s11307-020-01506-8
Autor:
Björn Sigurdsson, Natalie L Hauglund, Tuomas O Lilius, Frida L-H Mogensen, Kristian N Mortensen, Natalie Beschorner, Laura Klinger, Simone L Bærentzen, Marko P Rosenholm, Vladimir Shalgunov, Matthias Herth, Yuki Mori, Maiken Nedergaard
Publikováno v:
Sigurdsson, B, Hauglund, N L, Lilius, T O, Mogensen, F L H, Mortensen, K N, Beschorner, N, Klinger, L, Bærentzen, S L, Rosenholm, M P, Shalgunov, V, Herth, M, Mori, Y & Nedergaard, M 2023, ' A SPECT-based method for dynamic imaging of the glymphatic system in rats ', Journal of Cerebral Blood Flow and Metabolism, vol. 43, no. 7, pp. 1153-1165 . https://doi.org/10.1177/0271678X231156982
The glymphatic system is a brain-wide waste drainage system that promotes cerebrospinal fluid circulation through the brain to remove waste metabolites. Currently, the most common methods for assessing glymphatic function are ex vivo fluorescence mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eabd0a8ce22b82df022722572c22944
https://doi.org/10.1177/0271678x231156982
https://doi.org/10.1177/0271678x231156982
Autor:
Sofia Vestergaard Nielsen, Simone L. Baerentzen, Aage Kristian Olsen Alstrup, Mie Ringgaard Dollerup, Anne M. Landau, Ole Lajord Munk
Publikováno v:
Nielsen, S V, Dollerup, M R, Baerentzen, S L, Landau, A, Munk, O L & Alstrup, A K O 2021, ' Validation and optimization of an automatic blood sampler for preclinical positron emission tomography (PET) research in domestic pigs ', Laboratory Animals, vol. 0, 236772211049081 . https://doi.org/10.1177/00236772211049081
In preclinical positron emission tomography (PET) animal studies, continuous blood sampling is used to measure the time course of the activity concentration in arterial blood. However, pigs have hypercoagulable blood that tends to clot inside plastic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8859d054cb64375115c1d2da03f894f9
https://pure.au.dk/portal/da/publications/validation-and-optimization-of-an-automatic-blood-sampler-for-preclinical-positron-emission-tomography-pet-research-in-domestic-pigs(35d27c4a-ad74-4c8d-9b65-d042a70f031a).html
https://pure.au.dk/portal/da/publications/validation-and-optimization-of-an-automatic-blood-sampler-for-preclinical-positron-emission-tomography-pet-research-in-domestic-pigs(35d27c4a-ad74-4c8d-9b65-d042a70f031a).html
Autor:
David J. Brooks, Simone L. Baerentzen, M.N. Nielsen, Marucia Chacur, Karina Henrique Binda, Anne M. Landau, Thea P. Lillethorup, Caroline Cristiano Real, Dariusz Orlowski
Publikováno v:
Binda, K H, Lillethorup, T P, Real, C C, Bærentzen, S L, Nielsen, M N, Orlowski, D, Brooks, D J, Chacur, M & Landau, A M 2021, ' Exercise protects synaptic density in a rat model of Parkinson's disease ', Experimental Neurology, vol. 342, pp. 113741 . https://doi.org/10.1016/j.expneurol.2021.113741
Binda, K H, Lillethorup, T P, Real, C C, Bærentzen, S L, Nielsen, M N, Orlowski, D, Brooks, D J, Chacur, M & Landau, A M 2021, ' Exercise protects synaptic density in a rat model of Parkinson's disease ', Experimental Neurology, pp. 113741 . https://doi.org/10.1016/j.expneurol.2021.113741
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Binda, K H, Lillethorup, T P, Real, C C, Bærentzen, S L, Nielsen, M N, Orlowski, D, Brooks, D J, Chacur, M & Landau, A M 2021, ' Exercise protects synaptic density in a rat model of Parkinson's disease ', Experimental Neurology, pp. 113741 . https://doi.org/10.1016/j.expneurol.2021.113741
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
BACKGROUND: Parkinson's disease (PD) is characterized by Lewy body and neurite pathology associated with dopamine terminal dysfunction. Clinically, it is associated with motor slowing, rigidity, and tremor. Postural instability and pain are also feat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4728cd22929c16ce1b3bcfe9e64038f5
https://pure.au.dk/portal/da/publications/exercise-protects-synaptic-density-in-a-rat-model-of-parkinsons-disease(e7d7d7ba-f7b3-4034-9fbb-fe548ee23002).html
https://pure.au.dk/portal/da/publications/exercise-protects-synaptic-density-in-a-rat-model-of-parkinsons-disease(e7d7d7ba-f7b3-4034-9fbb-fe548ee23002).html
Autor:
Martin Schain, Claus Svarer, Isabel Martinez-Tejada, Annemette Ringsted, Mikael Palner, Siria Medina, Patrick M. Fisher, Simone L. Baerentzen, D. Lange, Paul Cumming, Celia Kjaerby, Hedok Lee, Agata Casado-Sainz, Frederik Gudmundsen, Sune H. Keller
Publikováno v:
Neuropsychopharmacology
Casado-Sainz, A, Gudmundsen, F, Baerentzen, S L, Lange, D, Ringsted, A, Martinez-Tejada, I, Medina, S, Lee, H, Svarer, C, Keller, S H, Schain, M, Kjaerby, C, Fisher, P M, Cumming, P & Palner, M 2022, ' Dorsal striatal dopamine induces fronto-cortical hypoactivity and attenuates anxiety and compulsive behaviors in rats ', Neuropsychopharmacology, vol. 47, no. 2, pp. 454–464 . https://doi.org/10.1038/s41386-021-01207-y
Casado-Sainz, A, Gudmundsen, F, Baerentzen, S L, Lange, D, Ringsted, A, Martinez-Tejada, I, Medina, S, Lee, H, Svarer, C, Keller, S H, Schain, M, Kjaerby, C, Fisher, P M, Cumming, P & Palner, M 2022, ' Dorsal striatal dopamine induces fronto-cortical hypoactivity and attenuates anxiety and compulsive behaviors in rats ', Neuropsychopharmacology, vol. 47, no. 2, pp. 454–464 . https://doi.org/10.1038/s41386-021-01207-y
Dorsal striatal dopamine transmission engages the cortico-striato-thalamo-cortical (CSTC) circuit, which is implicated in many neuropsychiatric diseases, including obsessive-compulsive disorder (OCD). Yet it is unknown if dorsal striatal dopamine hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a08771137bb9fb92f8bdc01513781f7
https://pubmed.ncbi.nlm.nih.gov/34725486
https://pubmed.ncbi.nlm.nih.gov/34725486
Autor:
Simone L. Baerentzen, Tomas Ohlsson, Maria Erlandsson, Mikael Palner, Vladimir Shalgunov, Elina T. L’Estrade, Fraser G. Edgar, Balázs Volk, Mengfei Xiong, Matthias M. Herth, Gitte M. Knudsen
Publikováno v:
ACS Chemical Neuroscience. 10:3961-3968
The latest addition to the serotonin (5-HT) receptor family is the 5-HT7 receptor (5-HT7R). This receptor has gained interest as a drug target due to its involvement in various disorders such as depression or schizophrenia. There is currently no clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e48835a709a1dc97e167750d94bb5318
https://doi.org/10.1021/acschemneuro.9b00132
https://doi.org/10.1021/acschemneuro.9b00132
Autor:
Simone L. Baerentzen, Maria Erlandsson, Vladimir Shalgunov, Mengfei Xiong, Elina T. L’Estrade, Mikael Palner, Gitte M. Knudsen, Fraser G. Edgar, Tomas Ohlsson, Matthias M. Herth
Publikováno v:
ACS Omega, Vol 4, Iss 4, Pp 7344-7353 (2019)
Tampio L'Estrade, E, Edgar, F G, Xiong, M, Shalgunov, V, Baerentzen, S L, Erlandsson, M, Ohlsson, T G, Palner, M, Knudsen, G M & Herth, M M 2019, ' Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of [ 18 F]ENL30 : A Potential PET Radiotracer for the 5-HT 7 Receptor ', ACS Omega, vol. 4, no. 4, pp. 7344-7353 . https://doi.org/10.1021/acsomega.9b00394
Tampio L'Estrade, E, Edgar, F G, Xiong, M, Shalgunov, V, Baerentzen, S L, Erlandsson, M, Ohlsson, T G, Palner, M, Knudsen, G M & Herth, M M 2019, ' Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of [ 18 F]ENL30 : A Potential PET Radiotracer for the 5-HT 7 Receptor ', ACS Omega, vol. 4, no. 4, pp. 7344-7353 . https://doi.org/10.1021/acsomega.9b00394
The 5-HT 7 receptor (5-HT 7 R) is involved in a broad range of physiological conditions and disorders. Currently, there is no validated clinical positron emission tomography (PET) tracer available; however, we have recently developed a promising 11 C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee8b6904a2004110d014fb2a6689667
https://doaj.org/article/a2f7493d2aa241d4aaf74d2a67c30505
https://doaj.org/article/a2f7493d2aa241d4aaf74d2a67c30505
Autor:
Paul Cumming, Isabel Martinez-Tajada, Mikael Palner, Martin Schain, Frederik Gudmundsen, Patrick M. Fisher, Siria Medina, Annemette Ringsted, Hedok Lee, Agata Casado-Sainz, Celia Kjaerby, D. Lange, Sune H. Keller, Simone L. Baerentzen, Claus Svarer
Dorsal striatal dopamine transmission engages the cortico-striato-thalamo-cortical (CSTC) circuit, which is implicated in many neuropsychiatric diseases, including obsessive-compulsive disorder (OCD). Yet it is unknown if dorsal striatal dopamine hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::955dfe5846120e91859c47675e27a22d
https://doi.org/10.1101/2021.02.11.430770
https://doi.org/10.1101/2021.02.11.430770