Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Simone Kunz"'
Autor:
Oliver J. Acton, Devon Sheppard, Simone Kunzelmann, Sarah J. Caswell, Andrea Nans, Ailidh J. O. Burgess, Geoff Kelly, Elizabeth R. Morris, Peter B. Rosenthal, Ian A. Taylor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract SAMHD1 regulates cellular nucleotide homeostasis, controlling dNTP levels by catalysing their hydrolysis into 2’-deoxynucleosides and triphosphate. In differentiated CD4+ macrophage and resting T-cells SAMHD1 activity results in the inhibi
Externí odkaz:
https://doaj.org/article/bfb935999e6b47258373d8f78633ef6d
Autor:
Katarzyna W. Kliza, Wei Song, Irene Pinzuti, Simone Schaubeck, Simone Kunzelmann, David Kuntin, Arianna Fornili, Alessandro Pandini, Kay Hofmann, James A. Garnett, Benjamin Stieglitz, Koraljka Husnjak
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Signalling through TNFR1 modulates proinflammatory gene transcription and programmed cell death, and its impairment causes autoimmune diseases and cancer. NEDD4-binding protein 1 (N4BP1) is a critical suppressor of proinflammatory cytokine p
Externí odkaz:
https://doaj.org/article/c56e0ffe40c84e808168dcef7ae2ce0a
Autor:
Konstantinos Koussis, Silvia Haase, Chrislaine Withers-Martinez, Helen R Flynn, Simone Kunzelmann, Evangelos Christodoulou, Fairouz Ibrahim, Mark Skehel, David A Baker, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012360 (2024)
The cGMP-dependent protein kinase (PKG) is the sole cGMP sensor in malaria parasites, acting as an essential signalling hub to govern key developmental processes throughout the parasite life cycle. Despite the importance of PKG in the clinically rele
Externí odkaz:
https://doaj.org/article/b62bcb1860a84ec8b769e6b711c15964
Autor:
Neil J. Rzechorzek, Simone Kunzelmann, Andrew G. Purkiss, Mariana Silva Dos Santos, James I. MacRae, Ian A. Taylor, Kasper Fugger, Stephen C. West
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the clinic to treat BRCA-deficient breast, ovarian and prostate cancers. As their efficacy is potentiated by loss of the nucleotide salvage factor DNPH1 there is considerable interest
Externí odkaz:
https://doaj.org/article/6e4d10f136754e82b50ca61ead5af62a
Autor:
Anne Isopp, Simone Kunz
Publikováno v:
wonderland – MANUAL FOR EMERGING ARCHITECTS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04283d207d31943f62b73ae06c621adb
https://doi.org/10.1515/9783035615388-058
https://doi.org/10.1515/9783035615388-058
Autor:
Jörg Lauterberg, Sonja Wunder, Horst Christian Vollmar, Petra Menn, Elmar Gräßel, Peter Marx, Carolin Donath, Hilmar Mehlig, Stephan Ruckdäschel, Reiner Leidl, Simone Kunz, Rolf Holle
Publikováno v:
Value in health 15(6), 851-859 (2012). doi:10.1016/j.jval.2012.06.007
Value Health 15, 851-859 (2012)
Value Health 15, 851-859 (2012)
Objective To compare a complex nondrug intervention including actively approaching counseling and caregiver support groups with differing intensity against usual care with respect to time to institutionalization in patients with dementia. Methods Wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af118c68cab81a4a37c16abface61491
https://doi.org/10.1016/j.jval.2012.06.007
https://doi.org/10.1016/j.jval.2012.06.007
Autor:
Elmar Graessel, Petra Menn, Peter Marx, Rolf Holle, Hilmar Mehlig, Reiner Leidl, Larissa Schwarzkopf, Jörg Lauterberg, Simone Kunz, Carolin Donath, Sonja Wunder
Publikováno v:
Value Health 14, 827-835 (2011)
Objective Rising life expectancy is associated with higher prevalence rates of dementia disorders. When disease progresses the patients' call on formal health care services and on social support grows which imposes increasing costs of care. The aim o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7949e1b4dc99bf83cb6eb2c845fefd66
https://doi.org/10.1016/j.jval.2011.04.005
https://doi.org/10.1016/j.jval.2011.04.005
Autor:
Simone Kunz
Publikováno v:
Quality of Life Research. 19:425-434
Due to their cognitive impairment, the health-related quality of life (HRQoL) of patients with dementia is often rated by proxies. This study aims to analyse the psychometric properties of the EQ-5D applied to patients with mild to moderate dementia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411a3112ddc4ca985ad9691b2e54778e
https://doi.org/10.1007/s11136-010-9600-1
https://doi.org/10.1007/s11136-010-9600-1
Autor:
Elizabeth R. Morris, Sarah J. Caswell, Simone Kunzelmann, Laurence H. Arnold, Andrew G. Purkiss, Geoff Kelly, Ian A. Taylor
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
SAMHD1 catalyses the hydrolysis of dNTPs into 2′-deoxynucleosides and triphosphate and is an important regulator of cellular dNTP homeostasis. Here, the authors provide insights into the catalytic mechanism of SAMHD1 by performing kinetic measureme
Externí odkaz:
https://doaj.org/article/33c0aeb332314b7f823450d37d5ea349
Autor:
Elmar Gräßel, Peter Marx, Rolf Holle, Simone Kunz, Jörg Lauterberg, Sonja Wunder, Larissa Schwarzkopf
Publikováno v:
Value in Health. 13:A449
Seen from societal perspective informal care is the major cost component in dementia care for community-living individuals. Values assigned to informal caregiving time are almost the three-fold of total health insurance’s expenditures. Hours family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c5e2e72b31b291cf584de12cca493a
https://doi.org/10.1016/s1098-3015(11)72899-6
https://doi.org/10.1016/s1098-3015(11)72899-6