Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Simone J.H. Wielders"'
Publikováno v:
Journal of Thrombosis and Haemostasis, 15(1), 140-149. Wiley
SummaryBackground Factor V (FV) is a carrier and a cofactor of the anticoagulant protein tissue factor pathway inhibitor-α (TFPIα), whose basic C-terminus binds to an acidic region in the B-domain of FV. Proteolysis of FV at Arg709, Arg1018 and Arg
Autor:
Marije ten Wolde, Arina J. ten Cate-Hoek, Simone J.H. Wielders, Elisabetta Castoldi, Hugo ten Cate, Y. Whitney Cheung, Henri M. H. Spronk, A.C. Bouman
Publikováno v:
Thrombosis research, 140, 106-109. Elsevier Limited
Thrombosis Research, 140, 106-109. Elsevier Science
Thrombosis Research, 140, 106-109. Elsevier Science
Objective Animal models suggest that toll-like receptor 9 (TLR9) promotes thrombus resolution after acute deep venous thrombosis (DVT). We hypothesized that TLR9 expression is lower in patients with post-thrombotic syndrome (PTS) and investigated the
Autor:
Theo Lindhout, H. Coenraad Hemker, Yesim Dargaud, Simone J.H. Wielders, Christine Trzeciak, Claude Negrier, Tilman M. Hackeng, Jean-Yves Scoazec, Elisabetta Castoldi
Publikováno v:
Blood, 125(9), 1497-1501. The American Society of Hematology
We describe a family with an autosomal dominant disorder characterized by severe trauma- and surgery-related bleeding. The proband, who experienced life-threatening bleeding during a routine operation, had normal clotting times, but markedly reduced
Autor:
Elisabetta Castoldi, Paolo Simioni, Nigel S. Key, Francesca Nuzzo, Kristy Lee, Simone J.H. Wielders, B. I. Nielsen, Cristiana Bulato
Publikováno v:
Haemophilia, 21(2), 241-248. Wiley
Coagulation factor V (FV) deficiency is a rare autosomal recessive bleeding disorder. We investigated a patient with severe FV deficiency (FV:C 3%) and moderate bleeding symptoms. Thrombin generation experiments showed residual FV expression in the p
Autor:
Gerry A. F. Nicolaes, Olivier Sperandio, Roy Schrijver, Bruno O. Villoutreix, Karin C. A. A. Wildhagen, Simone J.H. Wielders
Publikováno v:
Thrombosis Research, 133(6), 1105-1114. Elsevier Science
Introduction Activated protein C (APC) is the central enzyme of the anticoagulant protein C pathway. Low concentrations of APC circulate in plasma and are believed to contribute to the maintenance of a normal haemostatic balance. Materials and Method
Autor:
Matthew W. Bunce, Kamran Bakhtiari, Rodney M. Camire, Erol Fikrig, Gerry A. F. Nicolaes, Tim J. Schuijt, Tom van der Poll, Simone J.H. Wielders, Joppe W. Hovius, Kathleen DePonte, J. Arnoud Marquart, Cornelis van 't Veer, Sirlei Daffre, Joost C. M. Meijers
Publikováno v:
Circulation, 128(3), 254-266. Lippincott Williams and Wilkins
Circulation, 128(3), 254-266. LIPPINCOTT WILLIAMS & WILKINS
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Circulation, 128(3), 254-266. LIPPINCOTT WILLIAMS & WILKINS
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Background— Generation of active procoagulant cofactor factor Va (FVa) and its subsequent association with the enzyme activated factor X (FXa) to form the prothrombinase complex is a pivotal initial event in blood coagulation and has been the subje
Autor:
Hugo ten Cate, Simone J.H. Wielders, Theo Lindhout, Peter William Collins, Edouard M. Bevers, Jos L. V. Broers
Publikováno v:
Thrombosis and Haemostasis. 102:76-82
SummaryTo gain insight into the contribution of platelet-dependent thrombin formation in haemostasis and thrombosis, we investigated under flow conditions the haemostatic functions of platelets from a patient with Scott syndrome. Scott platelets are
Anticoagulant and antithrombotic properties of intracellular protease‐activated receptor antagonists
Autor:
Theo Lindhout, Chris P. M. Reutelingsperger, Simone J.H. Wielders, Edouard M. Bevers, Abdelkader Bennaghmouch
Publikováno v:
Journal of Thrombosis and Haemostasis. 5:571-576
Summary. Background: Blockade of the thrombin receptors protease-activated receptor (PAR)1 and PAR4 with pepducins, cell-penetrating lipopeptides based on the third intracellular loop of PAR1 and PAR4, effectively inhibits platelet aggregation. We ha
Autor:
Theo Lindhout, Chris P. M. Reutelingsperger, Simone J.H. Wielders, Lisette Ungethüm, Edouard M. Bevers
Publikováno v:
Thrombosis and Haemostasis. 98:1056-1062
SummaryPhosphatidylserine (PS) externalization of activated platelets plays a pivotal role in haemostasis and thrombosis. In the present study we have explored the relationship between the PS density of membranes and the rate of thrombin generation i
Publikováno v:
Journal of Thrombosis and Haemostasis. 4:1611-1617
Summary. Background: Apoptosis induces cellular membrane changes that are thought to be linked to thrombotic processes, for example, surface exposure of procoagulant phosphatidylserine (PtdSer), upregulation of tissue factor (TF), and microvesicle fo