Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Simone Jörs"'
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14317 (2010)
TRPML3, a member of the transient receptor potential (TRP) family, is an inwardly rectifying, non-selective Ca2+-permeable cation channel that is regulated by extracytosolic Na+ and H+ and can be activated by a variety of small molecules. The severe
Externí odkaz:
https://doaj.org/article/2b52b4f5e28f4c8e93e27caa8df95173
Autor:
Wai Ling Macrina Lam, Amruta Damle-Vartak, Gisela Gabernet, Doris Schneller, Tanja Poth, Simone Jörs, Melanie Sator-Schmitt, Aurora De Ponti, Lena Weiß, Mathias Heikenwälder, Nachiket Vartak, Jan G. Hengstler, Fabian Geisler, Sven Nahnsen, Peter Angel
Publikováno v:
Journal of Hepatology. 77:S38
Autor:
Georgia Guenther, Brigitte Begher-Tibbe, Adrian Friebel, Amruta Damle-Vartak, Nachiket Vartak, Florian Joly, Fabian Geisler, Simone Jörs, Jörns Fickel, Dirk Drasdo, Gudrun Wibbelt, Jan G. Hengstler, Ahmed Ghallab, Heribert Hofer, Stefan Hoehme, Irene E. Vignon-Clementel, Kasimir Wansing, Christian Hedberg, Marie Rosselin, Noemie Boissier, Peter L.M. Jansen
Publikováno v:
Hepatology, 73(4):1531-1550
Small-molecule flux in tissue-microdomains is essential for organ function, but knowledge of this process is scant due to the lack of suitable methods. We developed two independent techniques that allow the quantification of advection (flow) and diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edd02a9eaecd90ddb1de1d8de94aedd
Autor:
Thomas Longerich, Mihael Vucur, Hanna Honcharova-Biletska, Johannes Schmitt, Nadine T. Gaisa, Verena Keitel, Frank Tacke, Sarah Comtesse, Lena Küsgens, Mathias Heikenwalder, Roger J. Davis, Christoph Roderburg, Peter Boor, Marc E. Healy, Marta Szydlowska, Lap Kwan Chan, Enrico Focaccia, Mirco Castoldi, Achim Weber, Christian Preisinger, Tom Luedde, Friederike Böhm, Michèle Egger, Fabian Geisler, Simone Jörs, Anne T. Schneider, Yannick Boege, Katrin Müller, Johannes G. Bode, Christiane Koppe, Sven H. Loosen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(12), e2007194118 (2021). doi:10.1073/pnas.2007194118
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America 118(12), e2007194118 (2021). doi:10.1073/pnas.2007194118
Proceedings of the National Academy of Sciences
Significance JNK signaling has been studied intensively in models of liver physiology and disease, but previous studies had focused on young mice. However, it had not been recognized that JNK plays a fundamental role in maintaining liver homeostasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40191e6b4153326f76b4d2f1a7083f54
https://mediatum.ub.tum.de/doc/1637116/document.pdf
https://mediatum.ub.tum.de/doc/1637116/document.pdf
Autor:
Noemie Boissier, Amruta Damle-Vartak, Florian Joly, Jörns Fickel, Brigitte Begher-Tibbe, Georgia Guenther, Fabian Geisler, Simone Jörs, Gudrun Wibbelt, Marie Rosselin, Kasimir Wansing, Christian Hedberg, Peter L.M. Jansen, Adrian Friebel, Nachiket Vartak, Dirk Drasdo, Irene E. Vignon-Clementel, Ahmed Ghallab, Heribert Hofer, Stefan Hoehme, Jan G. Hengstler
Small-molecule flux in tissue-microdomains is essential for organ function, but knowledge of this process is scant due to the lack of suitable methods. We developed two independent techniques that allow the quantification of advection (flow) and diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1ab98e4fa7fe5ddda5d83b1f7f93ead
https://doi.org/10.1101/778803
https://doi.org/10.1101/778803
Autor:
Anil K. Rustgi, Dieter Saur, Jens T. Siveke, Matthias Wirth, Fabian Geisler, Simone Jörs, Sandra Diersch, Roland M Schmid, Roland Rad, Maximilian Reichert, Günter Schneider, Christian Schneeweis
Publikováno v:
Oncogene
Epidermal growth factor receptor (EGFR) signaling has a critical role in oncogenic Kras-driven pancreatic carcinogenesis. However, the downstream targets of this signaling network are largely unknown. We developed a novel model system utilizing murin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dcfaeaa93550ca2a7443ff968a458c
http://europepmc.org/articles/pmc4877299
http://europepmc.org/articles/pmc4877299
Publikováno v:
Journal of Biological Chemistry. 287:22701-22708
The transient receptor potential channels TRPML2 and TRPML3 (MCOLN2 and MCOLN3) are nonselective cation channels. They are widely expressed in mammals. However, little is known about their physiological function(s) and activation mechanism(s). TRPML3
Autor:
S. Adrian Saldanha, Alexander G. Obukhov, Christian Grimm, Peter Chase, Math P. Cuajungco, Simone Jörs, Stefan Heller, Bifeng Pan, Kazuo Oshima, Peter Hodder
Publikováno v:
Chemistry & Biology. 17:135-148
SummaryWe conducted a high-throughput screen for small molecule activators of the TRPML3 ion channel, which, when mutated, causes deafness and pigmentation defects. Cheminformatics analyses of the 53 identified and confirmed compounds revealed nine d
Publikováno v:
Journal of Biological Chemistry. 284:13823-13831
The varitint-waddler mutation A419P renders TRPML3 constitutively active, resulting in cationic overload, particularly in sustained influx of Ca2+. TRPML3 is expressed by inner ear sensory hair cells, and we were intrigued by the fact that hair cells
Autor:
Michael E. Schnee, Corné J. Kros, Math P. Cuajungco, Anthony J. Ricci, Stefan Heller, Alexander F. J. van Aken, Simone Jörs, Christian Grimm
Publikováno v:
Proceedings of the National Academy of Sciences. 104:19583-19588
Homozygote varitint-waddler ( Va ) mice, expressing a mutant isoform (A419P) of TRPML3 (mucolipin 3), are profoundly deaf and display vestibular and pigmentation deficiencies, sterility, and perinatal lethality. Here we show that the varitint-waddler