Výsledky vyhledávání - "Simone H. Stahl"

Challenges and Opportunities for Improved Drug–Drug Interaction Predictions for Renal OCT2 and MATE1/2‐K Transporters

Autor: Srinivasan Krishnan, Diane Ramsden, Douglas Ferguson, Simone H. Stahl, Joanne Wang, Dermot F. McGinnity, Niresh Hariparsad

Publikováno v: Clinical Pharmacology & Therapeutics. 112:562-572

Transporters contribute to renal elimination of drugs; therefore drug disposition can be impacted if transporters are inhibited by comedicant drugs. Regulatory agencies have provided guidelines to assess potential drug-drug interaction (DDI) risk for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591761a554a12b03335024347cf8a4ee
https://doi.org/10.1002/cpt.2666

Zobrazit plný text záznamu

The analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC–MS

Autor: Ian D. Wilson, Simone H. Stahl, Karla Lee, Isobelle Grant, Robert S. Plumb, Leanne C. Nye, Theo O. Dare, Andy Nicholls, Rebecca Dargue, Rajiv Jalan, Muireann Coen

Publikováno v: Bioanalysis. 12:485-500

A U(H)PLC–MS/MS method is described for the analysis of acetaminophen and its sulphate, glucuronide, glutathione, cysteinyl and N-acetylcysteinyl metabolites in plasma using stable isotope-labeled internal standards. P-Aminophenol glucuronide and 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8254115d073f368fd25cbf07b6657b
https://doi.org/10.4155/bio-2020-0015

Zobrazit plný text záznamu

Regulation of Drug Transport Proteins-From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium

Autor: Kim L.R. Brouwer, Raymond Evers, Elizabeth Hayden, Shuiying Hu, Cindy Yanfei Li, Henriette E. Meyer zu Schwabedissen, Sibylle Neuhoff, Stefan Oswald, Micheline Piquette‐Miller, Chitra Saran, Noora Sjöstedt, Jason A. Sprowl, Simone H. Stahl, Wei Yue

Publikováno v: Clinical pharmacology and therapeutics. 112(3)

Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or toxicity of many drugs. Numerous mechanisms (e.g., nuclear receptors, epigenetic gene regulation, microRNAs, alternative splicing, post-translational modificati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68c32c6c436782d1824390f36499e3f
https://pubmed.ncbi.nlm.nih.gov/35989454

Zobrazit plný text záznamu

Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion

Autor: Pedro, Caetano-Pinto, Pär, Nordell, Tom, Nieskens, Katie, Haughan, Katherine S, Fenner, Simone H, Stahl

Publikováno v: ALTEX.

Accurate prediction of pharmacokinetic parameters such as renal clearance is fundamental to the development of effective and safe new treatments for patients. However, conventional renal models have a limited ability to predict renal drug secretion,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad58ee138747cc3a7fa4d0e68264416d
https://doi.org/10.14573/altex.2204011

Zobrazit plný text záznamu

Targeting Gastrointestinal Uptake Transporters

Autor: Simone H. Stahl, Johan X. Johansson, Beth Williamson, Katherine Fenner, Ravindra V. Alluri, Jason Grant Kettle, M. Raymond V. Finlay

Publikováno v: The Medicinal Chemist's Guide to Solving ADMET Challenges ISBN: 9781788012270

Membrane transporters are important determinants of cellular and tissue distribution of charged molecules. In the intestine, uptake transporters expressed at the apical membrane of enterocytes contribute to the dietary absorption of endogenous molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7579fba6de75407df41eb9b2bc4de65
https://doi.org/10.1039/9781788016414-00062

Zobrazit plný text záznamu

A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery

Autor: Martijn J. Wilmer, Ernst Ahlberg, Mikael Persson, Simone H. Stahl, Anna-Karin Sjögren, Malin Forsgard, Jorrit J. Hornberg, Lucas Milton, Katarina Breitholtz

Publikováno v: Archives of Toxicology, 92, 3175-3190
Archives of Toxicology, 92, 10, pp. 3175-3190

Contains fulltext : 196765.pdf (Publisher’s version ) (Closed access) Drug-induced nephrotoxicity is a major concern in the clinic and hampers the use of available treatments as well as the development of innovative medicines. It is typically disco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86edfea0e525dda11ec47e606d0d0513
https://doi.org/10.1007/s00204-018-2284-y

Zobrazit plný text záznamu

Perspective on the Application of Microphysiological Systems to Drug Transporter Studies

Autor: Simone H. Stahl, Pedro Caetano-Pinto

Publikováno v: Drug Metabolism and Disposition. 46:1647-1657

Transmembrane flux of a drug within a tissue or organ frequently involves a complex system of transporters from multiple families that have redundant and overlapping specificities. Current in vitro systems poorly represent physiology, with reduced ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe2316834448270dde7c9f72367aa10
https://doi.org/10.1124/dmd.118.082750

Zobrazit plný text záznamu

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity

Autor: Simone H. Stahl, Christina Battista, Paul B. Watkins, Scott Q. Siler, Jerome T. Mettetal, Kyunghee Yang, Brett A. Howell

Publikováno v: Toxicological Sciences

CKA, a chemokine receptor antagonist intended for treating inflammatory conditions, produced dose-dependent hepatotoxicity in rats but advanced into the clinic where single doses of CKA up to 600 mg appeared safe in humans. Because existing toxicolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b978f96547347f1557add929a62dd55e
https://doi.org/10.1093/toxsci/kfy191

Zobrazit plný text záznamu

Systems pharmacology modeling of drug‐induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters

Autor: Scott Q. Siler, Simone H. Stahl, Jeffrey L. Woodhead, Brett A. Howell, Christina Battista, Kyunghee Yang, Jerome T. Mettetal, Paul B. Watkins

Publikováno v: Clinical Pharmacology and Therapeutics

Elevations in serum bilirubin during drug treatment may indicate global liver dysfunction and a high risk of liver failure. However, drugs also can increase serum bilirubin in the absence of hepatic injury by inhibiting specific enzymes/transporters.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba10f5b6f0d3bc33487cda49213c9ef2
https://doi.org/10.1002/cpt.619

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání