Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Simone Greven"'
Autor:
Thomas Pohl, Annick Gervais, Eef H.C. Dirksen, Valerio D'Alessio, Karoline Bechtold-Peters, Will Burkitt, Li Cao, Simone Greven, Andrew Lennard, Xue Li, Christopher Lössner, Ben Niu, Dietmar Reusch, Tomás O'Riordan, Justin W. Shearer, David Spencer, Wei Xu, Linda Yi
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 188:231-242
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e131dfecc1449ca4d9cd594ea4c4846
https://doi.org/10.1016/j.ejpb.2023.04.024
https://doi.org/10.1016/j.ejpb.2023.04.024
Autor:
Bertolt Kreft, Karl Ziegelbauer, Hung Huynh, Rolf Jautelat, Heiner Apeler, Frank Reetz, Frank Dittmer, Axel Harrenga, Sabine Wittemer-Rump, Ruprecht Zierz, Manuela Braun, Joachim Schuhmacher, Simone Greven, Stefanie Hammer, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Christoph Mahlert, Carl F. Nising, Christoph A. Schatz, Charlotte Kopitz, Anette Sommer
Supplementary Materials and Methods and Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c478be8710ef66729548c4c9955f34ef
https://doi.org/10.1158/0008-5472.22413215
https://doi.org/10.1158/0008-5472.22413215
Autor:
Bertolt Kreft, Karl Ziegelbauer, Hung Huynh, Rolf Jautelat, Heiner Apeler, Frank Reetz, Frank Dittmer, Axel Harrenga, Sabine Wittemer-Rump, Ruprecht Zierz, Manuela Braun, Joachim Schuhmacher, Simone Greven, Stefanie Hammer, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Christoph Mahlert, Carl F. Nising, Christoph A. Schatz, Charlotte Kopitz, Anette Sommer
The fibroblast growth factor receptor FGFR2 is overexpressed in a variety of solid tumors, including breast, gastric, and ovarian tumors, where it offers a potential therapeutic target. In this study, we present evidence of the preclinical efficacy o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44ebc0b49659b36c8a0e1db50afdb784
https://doi.org/10.1158/0008-5472.c.6508652.v1
https://doi.org/10.1158/0008-5472.c.6508652.v1
Autor:
Bertolt Kreft, Karl Ziegelbauer, Hung Huynh, Rolf Jautelat, Heiner Apeler, Frank Reetz, Frank Dittmer, Axel Harrenga, Sabine Wittemer-Rump, Ruprecht Zierz, Manuela Braun, Joachim Schuhmacher, Simone Greven, Stefanie Hammer, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Christoph Mahlert, Carl F. Nising, Christoph A. Schatz, Charlotte Kopitz, Anette Sommer
The anti-tumor efficacy of different FGFR2-ADC BAY 1187982 treatment schedules on MFM-223 human TNBC mouse model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a269fcddc4ad2bbabdf8b05b57ef15
https://doi.org/10.1158/0008-5472.22413218
https://doi.org/10.1158/0008-5472.22413218
Autor:
Bertolt Kreft, Karl Ziegelbauer, Hung Huynh, Rolf Jautelat, Heiner Apeler, Frank Reetz, Frank Dittmer, Axel Harrenga, Sabine Wittemer-Rump, Ruprecht Zierz, Manuela Braun, Joachim Schuhmacher, Simone Greven, Stefanie Hammer, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Christoph Mahlert, Carl F. Nising, Christoph A. Schatz, Charlotte Kopitz, Anette Sommer
The expression of FGFR2 on tumor cell surface and half maximal inhibitory concentration of cell viability for FGFR2-ADC BAY 1187982 and control ADC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f3b511ae57fea3e60618670122dbb8
https://doi.org/10.1158/0008-5472.22413212.v1
https://doi.org/10.1158/0008-5472.22413212.v1
Autor:
Niels Böhnke, Markus Berger, Nils Griebenow, Antje Rottmann, Michael Erkelenz, Stefanie Hammer, Sandra Berndt, Judith Günther, Antje M. Wengner, Beatrix Stelte-Ludwig, Christoph Mahlert, Simone Greven, Lisa Dietz, Hannah Jörißen, Naomi Barak, Ulf Bömer, Roman C. Hillig, Uwe Eberspaecher, Jörg Weiske, Anja Giese, Dominik Mumberg, Carl Friedrich Nising, Hilmar Weinmann, Anette Sommer
Publikováno v:
Bioconjugate chemistry. 33(6)
Inhibition of intracellular nicotinamide phosphoribosyltransferase (NAMPT) represents a new mode of action for cancer-targeting antibody-drug conjugates (ADCs) with activity also in slowly proliferating cells. To extend the repertoire of available ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382f52dbd2ea6891f52b4f7a2d6e442b
https://pubmed.ncbi.nlm.nih.gov/35658441
https://pubmed.ncbi.nlm.nih.gov/35658441
Autor:
Hannah JÖRIßEN, Beatrix Stelte-Ludwig, Lisa Dietz, Simone Greven, Anette Sommer, Sarah Johannes, Anne-Sophie Rebstock, Hans-Georg Lerchen, Christoph Mahlert, Sandra Berndt
Publikováno v:
Bioconjugate Chemistry. 31:1893-1898
Several antibody-drug conjugates (ADCs) have failed to achieve a sufficiently large therapeutic window in patients due to toxicity induced by unspecific payload release in the circulation or ADC uptake into healthy organs. Herein, we describe the suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252e84c3e966a667b671fd1d96b8ef77
https://doi.org/10.1021/acs.bioconjchem.0c00357
https://doi.org/10.1021/acs.bioconjchem.0c00357
Autor:
Christoph Mahlert, Beatrix Stelte-Ludwig, Sarah Johannes, Lisa Dietz, Hannah JÖRIßEN, Hans-Georg Lerchen, Anette Sommer, Anne-Sophie Rebstock, Simone Greven, Leo Marx, Sandra Berndt
Publikováno v:
Chemistry – A European Journal. 25:8208-8213
Many antibody-drug conjugates (ADCs) have failed to achieve a sufficient therapeutic window in clinical studies either due to target-mediated or off-target toxicities. To achieve an additional safety level, a new class of antibody-prodrug conjugates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca64068636167b875be009f30e537947
https://doi.org/10.1002/chem.201900441
https://doi.org/10.1002/chem.201900441
Autor:
Sandra Johanssen, Pascale Buchmann, Hans-Georg Lerchen, Christoph Mahlert, Lisa Dietz, Ruprecht Zierz, Dennis Kirchhoff, Antje Margret Wengner, Stephan Märsch, Anette Sommer, Beatrix Stelte-Ludwig, Dominik Mumberg, Michael Erkelenz, Simone Greven, Oliver von Ahsen
Publikováno v:
Cancers
Volume 12
Issue 11
Cancers, Vol 12, Iss 3464, p 3464 (2020)
Volume 12
Issue 11
Cancers, Vol 12, Iss 3464, p 3464 (2020)
IL3RA (CD123) is the alpha subunit of the interleukin 3 (IL-3) receptor, which regulates the proliferation, survival, and differentiation of hematopoietic cells. IL3RA is frequently expressed in acute myeloid leukemia (AML) and classical Hodgkin lymp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911a4606c808e1a54227263040923acb
Autor:
Sven Wittrock, Carsten Terjung, Anne-Sophie Rebstock, Nils Griebenow, Anette Sommer, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Yolanda Cancho-Grande, Christoph Mahlert, Sarah Johannes, Sandra Berndt, Simone Greven
Publikováno v:
Angewandte Chemie International Edition. 57:15243-15247
The number of cytotoxic payload classes successfully employed in antibody-drug conjugates (ADCs) is still rather limited. The identification of ADC payloads with a novel mode of action will increase therapeutic options and potentially increase the th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1540c754f2b5da57e05a920741a4d1
https://doi.org/10.1002/anie.201807619
https://doi.org/10.1002/anie.201807619