Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Simone Gräßle"'
Autor:
Simone Gräßle, Laura Holzhauer, Nicolai Wippert, Olaf Fuhr, Martin Nieger, Nicole Jung, Stefan Bräse
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1396-1404 (2024)
A synthesis route to access triazole–pyrazole hybrids via triazenylpyrazoles was developed. Contrary to existing methods, this route allows the facile N-functionalization of the pyrazole before the attachment of the triazole unit via a copper-catal
Externí odkaz:
https://doaj.org/article/b334d831695d45069d60fb967475988d
Autor:
Lu Sun, Matthias Apweiler, Claus Normann, Christoph W. Grathwol, Thomas Hurrle, Simone Gräßle, Nicole Jung, Stefan Bräse, Bernd L. Fiebich
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 674 (2024)
Chronic inflammation is driven by proinflammatory cytokines such as interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), and chemokines, such as c-c motif chemokine ligand 2 (CCL2), CCL3, C-X-C motif chemokine ligand 2 (CXCL2), and CXCL10. Inflam
Externí odkaz:
https://doaj.org/article/5dec51038a2b4687ba75c872588109e1
Autor:
Diana Hofmann, Niharika Garg, Simone Grässle, Sylvia Vanderheiden, Bruno Gideon Bergheim, Stefan Bräse, Nicole Jung, Suat Özbek
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Cnidarians are characterized by the possession of stinging organelles, called nematocysts, which they use for prey capture and defense. Nematocyst discharge is controlled by a mechanosensory apparatus with analogies to vertebrate hair cells.
Externí odkaz:
https://doaj.org/article/a384450de5d943a085c65497e07df070
Autor:
Nane C. Kuznik, Valeria Solozobova, Irene I. Lee, Nicole Jung, Linxiao Yang, Karin Nienhaus, Emmanuel A. Ntim, Jaice T. Rottenberg, Claudia Muhle-Goll, Amrish Rajendra Kumar, Ravindra Peravali, Simone Gräßle, Victor Gourain, Célia Deville, Laura Cato, Antje Neeb, Marco Dilger, Christina A. Cramer von Clausbruch, Carsten Weiss, Bruno Kieffer, G. Ulrich Nienhaus, Myles Brown, Stefan Bräse, Andrew C.B. Cato
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104175- (2022)
Summary: BAG1 is a family of polypeptides with a conserved C-terminal BAG domain that functions as a nucleotide exchange factor for the molecular chaperone HSP70. BAG1 proteins also control several signaling processes including proteostasis, apoptosi
Externí odkaz:
https://doaj.org/article/ef7d174a265a47ad8c77177cd0835a85
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 515-522 (2018)
In the presented study, dithi(ol)anylium tetrafluoroborates are added to α,β-unsaturated ketones in a Michael-type reaction yielding diverse substituted ketene diothi(ol)anes. The reactions proceed at room temperature in 1 or 13 h without the need
Externí odkaz:
https://doaj.org/article/44b1e5ffa92d4114a1c120dfc216ca82
Autor:
Rick Raudszus, Andrea Paulig, Nicole Urban, Anke Deckers, Simone Gräßle, Sylvia Vanderheiden, Nicole Jung, Stefan Bräse, Michael Schaefer, Kerstin Hill
Publikováno v:
British Journal of Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aed454fe6357b8e8d182823f24ee5c6
https://doi.org/10.1111/bph.16154
https://doi.org/10.1111/bph.16154
Autor:
Antje Neeb, Ines Figueiredo, Denisa Bogdan, Laura Cato, Jutta Stober, Juan M. Jimenez-Vacas, Victor Gourain, Irene I. Lee, Rebecca Seeger, Claudia Muhle-Goll, Bora Gurel, Jonathan Welti, Daniel Nava Rodrigues, Jan Rekowski, Xintao Qiu, Yija Jiang, Patrizio Di Micco, Borja Mateos, Stasė Bielskutė, Ruth Riisnaes, Ana Ferreira, Susana Miranda, Mateus Crespo, Lorenzo Buroni, Jian Ning, Stefan Bräse, Nicole Jung, Simone Gräßle, Daniel Metzger, Amanda Swain, Xavier Salvatella, Stephen R. Plymate, Bissan Al-Lazikani, Henry Long, Wei Yuan, Myles Brown, Andrew C. B. Cato, Johann S. de Bono, Adam Sharp
Therapies that abrogate persistent androgen receptor (AR) signaling in castration resistant prostate cancer (CRPC) remain an unmet clinical need. The N-terminal domain (NTD) of the AR drives transcriptional activity in CRPC but is intrinsically disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b328ddc5c1df4c2271cc5ed3e5422667
https://doi.org/10.1101/2022.10.17.512378
https://doi.org/10.1101/2022.10.17.512378
Autor:
Matthias Apweiler, Jana Streyczek, Soraya Wilke Saliba, Juan Antonio Collado, Thomas Hurrle, Simone Gräßle, Eduardo Muñoz, Claus Normann, Sabine Hellwig, Stefan Bräse, Bernd L. Fiebich
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 959
International Journal of Molecular Sciences, Vol 23, Iss 959, p 959 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 23 (2), 959
International Journal of Molecular Sciences, Vol 23, Iss 959, p 959 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 23 (2), 959
Anti-neuroinflammatory treatment has gained importance in the search for pharmacological treatments of different neurological and psychiatric diseases, such as depression, schizophrenia, Parkinson’s disease, and Alzheimer’s disease. Clinical stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7cf8d5c211ac2c028aa975a3ea4faa9
Autor:
Sylvia Vanderheiden, Nicole Jung, Stefan Bräse, Niharika Garg, Diana Hofmann, Bruno Gideon Bergheim, Simone Grässle, Suat Özbek
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific reports, 11, Art.-Nr. 20627
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific reports, 11, Art.-Nr. 20627
Cnidarians are characterized by the possession of stinging organelles, called nematocysts, which they use for prey capture and defense. Nematocyst discharge is controlled by a mechanosensory apparatus with analogies to vertebrate hair cells. Members
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4d4616cb27b34332cae4b824a144ef
http://europepmc.org/articles/PMC8523708
http://europepmc.org/articles/PMC8523708
Autor:
Nane C Kuznik, Simone Gräßle, Andrew C.B. Cato, Qing Lei, Nicole Jung, Amina Zoubeidi, Eric M. Lewandowski, Valeria Solozobova, Ravi Shashi Nayana Munuganti, Stefan Bräse, Yu Chen
Publikováno v:
ACS chemical biology. 16(11)
All current clinically approved androgen deprivation therapies for prostate cancer target the C-terminal ligand-binding domain of the androgen receptor (AR). However, the main transactivation function of the receptor is localized at the AR N-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d8a7ed2a77a8c7d22874296fa12fcb
https://pubmed.ncbi.nlm.nih.gov/34506104
https://pubmed.ncbi.nlm.nih.gov/34506104