Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Simone Giovannuzzi"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
This study refers to the intricate world of Acinetobacter baumannii, a resilient pathogenic bacterium notorious for its propensity at antibiotic resistance in nosocomial infections. Expanding upon previous findings that emphasised the bifunctional en
Externí odkaz:
https://doaj.org/article/2695134eb484442e93e679573d836733
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Toxoplasmosis, induced by the intracellular parasite Toxoplasma gondii, holds considerable implications for global health. While treatment options primarily focusing on folate pathway enzymes have notable limitations, current research endeavours conc
Externí odkaz:
https://doaj.org/article/f91536a23fc84dd687c7b04590f9c026
Autor:
Simone Giovannuzzi, Anil Kumar Marapaka, Nader S. Abutaleb, Fabrizio Carta, Hsin-Wen Liang, Alessio Nocentini, Luigi Pisano, Mohamed N. Seleem, Daniel P. Flaherty, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Carbonic anhydrases (CAs) from the pathogenic bacteria Nesseria gonorrhoeae and vancomycin-resistant enterococci (VRE) have recently been validated as antibacterial drug targets. Here we explored the inhibition of the α-CA from N. gonorrhoeae (α-Ng
Externí odkaz:
https://doaj.org/article/c4d2014469974e81944e86da38a9887d
Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors
Autor:
Simone Giovannuzzi, Alessandro Bonardi, Paola Gratteri, Alessio Nocentini, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Considering the unrecognised physio-pathological role of human carbonic anhydrase III (hCA III), a structure-based drug design was set up to identify the first-in-class potent and selective inhibitors of this neglected isoform. hCA III targeting was
Externí odkaz:
https://doaj.org/article/0d1cac7dbab14fcaad0a75ab557ea796
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
The γ-carbonic anhydrase (CA, EC 4.2.1.1) from the pathogenic bacterium, Mammaliicoccus (Staphylococcus) sciuri (MscCAγ) was recently cloned and purified by our groups. Here we investigated inhibition of this enzyme with (in)organic simple and comp
Externí odkaz:
https://doaj.org/article/37083c9acd3742bf945bb361909dda21
Autor:
Simone Giovannuzzi, Chad S. Hewitt, Alessio Nocentini, Clemente Capasso, Daniel P. Flaherty, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 333-338 (2022)
Coumarins are known to act as prodrug inhibitors of mammalian α-carbonic anhydrases (CAs, EC 4.2.1.1) but they were not yet investigated for the inhibition of bacterial α-CAs. Here we demonstrate that such enzymes from the bacterial pathogens Neiss
Externí odkaz:
https://doaj.org/article/28b2248586f446c9ba2b17701ba77732
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 680-685 (2022)
Coumarins were discovered to act as inhibitors of α-carbonic anhydrases (CAs, EC 4.2.1.1) after undergoing hydrolysis mediated by the esterase activity of the enzyme to the corresponding 2-hydroxycinnamic acids. Other classes of CAs among the eight
Externí odkaz:
https://doaj.org/article/147989acf6304c66964b6afec2088733
Autor:
Simone Giovannuzzi, Chad S. Hewitt, Alessio Nocentini, Clemente Capasso, Gabriele Costantino, Daniel P. Flaherty, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 666-671 (2022)
The α-class carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogens Neisseria gonorrhoeae (NgCAα) and Vibrio cholerae (VchCAα) were investigated for their inhibition by a panel of phenols and phenolic acids. Mono-, di- and tri-substitut
Externí odkaz:
https://doaj.org/article/ef33c490e1294667bda40aef295498e2
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1568-1576 (2022)
The treatment of chronic neuropathic pain remains one of the most challenging of all neurological diseases and very much an art. There exists no consensus for the optimal management of this condition at the moment. Gaining inspiration from recent stu
Externí odkaz:
https://doaj.org/article/23d50ef1fde34a48ac00de547d2e0ed2
Autor:
Simone Giovannuzzi, Nader S. Abutaleb, Chad S. Hewitt, Fabrizio Carta, Alessio Nocentini, Mohamed N. Seleem, Daniel P. Flaherty, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1-8 (2022)
Recently, inorganic anions and sulphonamides, two of the main classes of zinc-binding carbonic anhydrase inhibitors (CAIs), were investigated for inhibition of the α-class carbonic anhydrase (CA, EC 4.2.1.1) from Neisseria gonorrhoeae, NgCA. As an e
Externí odkaz:
https://doaj.org/article/8103ce235a6247a5897dbdaf78bc3e41