Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Simone Engelender"'
Autor:
Jun Dong, Li Chen, Fei Ye, Junhui Tang, Bing Liu, Jiacheng Lin, Pang-Hu Zhou, Bin Lu, Min Wu, Jia-Hong Lu, Jing-Jing He, Simone Engelender, Qingtao Meng, Zhiyin Song, He He
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid transport, synthesis, and metabolism. However, the molecular mechanism and physiological function of endoplasmic reticulum-mitochondrial contacts remai
Externí odkaz:
https://doaj.org/article/9ce0791913fe4ff9aa6525cb89bbb6a4
Autor:
Tianshu Hao, Jianglong Yu, Zhida Wu, Jie Jiang, Longlong Gong, Bingjun Wang, Hanze Guo, Huabin Zhao, Bin Lu, Simone Engelender, He He, Zhiyin Song
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade misfolded proteins and damaged organelles to maintain cellular homeosta
Externí odkaz:
https://doaj.org/article/21df65c007b74e62808b5795885d6a13
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract This article describes pathogenic concepts and factors, in particular glycolipid abnormalities, that create cell dysfunction and synaptic loss in neurodegenerative diseases. By phenocopying lysosomal storage disorders, such as Gaucher diseas
Externí odkaz:
https://doaj.org/article/723f5fe59ef4435eb1d40b735cd6d9f3
Autor:
Mor Savyon, Simone Engelender
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
The accumulation and aggregation of α-synuclein are central to Parkinson’s disease (PD), yet the molecular mechanisms responsible for these events are not fully understood. Post-translational modifications of α-synuclein regulate several of its p
Externí odkaz:
https://doaj.org/article/94569cff419e49b18e173c4dbfb846c0
Autor:
Frederick C. Nucifora, Leslie G. Nucifora, Chee-Hoe Ng, Nicolas Arbez, Yajuan Guo, Elaine Roby, Vered Shani, Simone Engelender, Dong Wei, Xiao-Fang Wang, Tianxia Li, Darren J. Moore, Olga Pletnikova, Juan C. Troncoso, Akira Sawa, Ted M. Dawson, Wanli Smith, Kah-Leong Lim, Christopher A. Ross
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Mutations in LRRK2 are linked to Parkinson’s Disease. Here, the authors identify WSB1 as a LRRK2 interacting protein and find that it promotes LRRK2 aggregation in primary neurons and drosophila models via ubiquitin K27 and K29 linkages.
Externí odkaz:
https://doaj.org/article/0422154ec8e94aaeacb24bc6f49b8afd
Autor:
Adeline H. Basil, Joan P. L. Sim, Grace G. Y. Lim, Shuping Lin, Hui Ying Chan, Simone Engelender, Kah-Leong Lim
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Afadin 6 (AF-6) is an F-actin binding multidomain-containing scaffolding protein that is known for its function in cell-cell adhesion. Interestingly, besides this well documented role, we recently found that AF-6 is a Parkin-interacting protein that
Externí odkaz:
https://doaj.org/article/866310369a4545c09db1b65b6769adfe
Autor:
Rina Bandopadhyay, Ann E. Kingsbury, Miratul M. Muqit, Kirsten Harvey, Andrew R. Reid, Linda Kilford, Simone Engelender, Michael G. Schlossmacher, Nicholas W. Wood, David S. Latchman, Robert J. Harvey, Andrew J. Lees
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 401-411 (2005)
Lewy bodies (LBs) are the characteristic inclusions of Parkinson's disease brain but the mechanism responsible for their formation is obscure. Lewy bodies (LBs) are composed of a number of proteins of which alpha-synuclein (α-SYN) is a major constit
Externí odkaz:
https://doaj.org/article/6f0ed25c8e0f4630918b13e818439830
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 87, Pp 67-70 (1992)
Protein extracts obtained from male and female shistosomes were incubated with a gender-specific gene, F-10, transcribed only in adult females and encoding a major egg-shell protein. The protein/DNA interaction was measured using the band shift, DNas
Externí odkaz:
https://doaj.org/article/f8df7603e9444713b4648ce845941aeb
Autor:
Fatimah Abd Elghani, Hazem Safory, Haya Hamza, Mor Savyon, Malik Farhoud, Michal Toren‐Hershoviz, Zagorka Vitic, Kirsten Ebanks, Vered Shani, Sleman Bisharat, Lihi Shaulov, Claude Brodski, Zhiyin Song, Rina Bandopadhyay, Simone Engelender
Publikováno v:
Aging cell. 21(12)
Parkinson's disease (PD) is characterized by degeneration of neurons, particularly dopaminergic neurons in the substantia nigra. PD brains show accumulation of α-synuclein in Lewy bodies and accumulation of dysfunctional mitochondria. However, the m
Autor:
Tianshu Hao, Jianglong Yu, Zhida Wu, Jie Jiang, Long Gong, Bing-Jun Wang, Huabin Zhao, Bin Lu, Simone Engelender, He He, Zhiyin Song
Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to produce ATP to power the cell. Lysosomes contain hydrolytic enzymes that degrade misfolded proteins and damaged organelles, including mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ebc35f85fe7bf7d643fd360b2c29fea
https://doi.org/10.21203/rs.3.rs-1683272/v1
https://doi.org/10.21203/rs.3.rs-1683272/v1