Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Simone E Salghetti"'
Autor:
Scott W. Lowe, Michael T. Hemann, Andreas Herbst, William P. Tansey, Simone E Salghetti, Kathryn A Tworkowski
Publikováno v:
EMBO reports. 6:177-183
Myc is an oncoprotein transcription factor that promotes cell proliferation and apoptosis. Analysis of highly conserved elements within vertebrate Myc proteins has been instrumental in defining the functions of the Myc protein. Here, we probe the rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9ad0088cef47811633dec5c76b30ee
https://doi.org/10.1038/sj.embor.7400333
https://doi.org/10.1038/sj.embor.7400333
Autor:
Robert H. Singer, Susan M. Janicki, Yaron Shav-Tal, Edouard Bertrand, David L. Spector, William P. Tansey, Thomas Ried, Simone E Salghetti, Ravi Sachidanandam, Kannanganattu V. Prasanth, Toshiro Tsukamoto
Publikováno v:
Cell. 116(5):683-698
We have developed an inducible system to visualize gene expression at the levels of DNA, RNA and protein in living cells. The system is composed of a 200 copy transgene array integrated into a euchromatic region of chromosome 1 in human U2OS cells. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228daef8b27adf169ec1c077c885a29d
Autor:
Simone E Salghetti, Lock M, A.J. Iafrate, Michael E. Greenberg, Roberto Mariani, Jacek Skowronski, Tomek Swigut
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 64:453-464
One striking aspect of immunodeficiency viruses istheir ability to replicate and maintain persistent infectionin the face of the host immune response and to eventuallyovercome this response (Desrosiers 1999). The progressive loss of CD4+ T lymphocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d3567339cd00fc017045f655b9212a
https://doi.org/10.1101/sqb.1999.64.453
https://doi.org/10.1101/sqb.1999.64.453
Publikováno v:
Science. 293:1651-1653
The ability of transcriptional activation domains (TADs) to signal ubiquitin-mediated proteolysis suggests an involvement of the ubiquitin-proteasome pathway in transcription. To probe this involvement, we asked how ubiquitylation regulates the activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e2de29a9f589fb64fe69abf4875afe
https://doi.org/10.1126/science.1062079
https://doi.org/10.1126/science.1062079
Autor:
Marc J. Mass, Brenda I. Gerwin, Gary D. Stoner, Anthony J. Galati, Simone E. Salghetti, Ih-Chang Hsu, Roger R. Reddel, Angela N. A. Somers, William T. Gunning, Curtis C. Harris, Bharati Hukku
Publikováno v:
International Journal of Cancer. 48:764-773
Bronchial epithelial cells were cultured from an individual with no evidence of malignant disease. These cells, designated HB56B, had a greatly extended in vitro life-span, being able to undergo 50 passages and 200 population doublings in contrast to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8155b96a939c6467a179969bad67f8f8
https://doi.org/10.1002/ijc.2910480522
https://doi.org/10.1002/ijc.2910480522
Autor:
Jonathan M. Geisinger, William P. Tansey, Simone E Salghetti, Anne Daulny, Fuqiang Geng, Masafumi Muratani
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(50)
Emerging evidence suggests that components of the ubiquitin–proteasome system are involved in the regulation of gene expression. A variety of factors, including transcriptional activators, coactivators, and histones, are controlled by ubiquitylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92be1e58e2306640d02029d822932fb
https://pubmed.ncbi.nlm.nih.gov/19064926
https://pubmed.ncbi.nlm.nih.gov/19064926
Publikováno v:
Oncogene. 23(21)
Myc is a highly unstable transcription factor that is destroyed by ubiquitin (Ub)-mediated proteolysis. We have previously identified an amino-terminal 'degron' within Myc that signals its destruction; this degron spans the transcriptional activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d842015fd0bdc972a3fcca520e4a04
https://pubmed.ncbi.nlm.nih.gov/15021906
https://pubmed.ncbi.nlm.nih.gov/15021906
Autor:
Susan M, Janicki, Toshiro, Tsukamoto, Simone E, Salghetti, William P, Tansey, Ravi, Sachidanandam, Kannanganattu V, Prasanth, Thomas, Ried, Yaron, Shav-Tal, Edouard, Bertrand, Robert H, Singer, David L, Spector
Publikováno v:
Cell. 116(5)
We have developed an inducible system to visualize gene expression at the levels of DNA, RNA and protein in living cells. The system is composed of a 200 copy transgene array integrated into a euchromatic region of chromosome 1 in human U2OS cells. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df954f9af686fb905beec244e50f4584
https://pubmed.ncbi.nlm.nih.gov/15006344
https://pubmed.ncbi.nlm.nih.gov/15006344
Publikováno v:
Molecular cell. 11(5)
Myc is an oncoprotein transcription factor that plays a prominent role in cancer. Like many transcription factors, Myc is an unstable protein that is destroyed by ubiquitin (Ub)-mediated proteolysis. Here, we report that the oncoprotein and Ub ligase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f37d583770e5755a3a08f4cee1b1a1c
https://pubmed.ncbi.nlm.nih.gov/12769843
https://pubmed.ncbi.nlm.nih.gov/12769843
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 97(7)
Many transcription factors, particularly those involved in the control of cell growth, are unstable proteins destroyed by ubiquitin-mediated proteolysis. In a previous study of sequences targeting the transcription factor Myc for destruction, we obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab549743efb026b727c943779bc5a41
https://pubmed.ncbi.nlm.nih.gov/10706616
https://pubmed.ncbi.nlm.nih.gov/10706616