Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Simone Di Giacomo"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2023)
Tumor cells exploit multiple mechanisms to evade apoptosis, hence the strategies aimed at reactivating cell death in cancer. However, recent studies are revealing that dying cells play remarkable pro-oncogenic roles. Among the mechanisms promoting ce
Externí odkaz:
https://doaj.org/article/d566a783a100484e87007139b99458c7
Autor:
Myrthala Moreno-Smith, Giorgio Milazzo, Ling Tao, Baharan Fekry, Bokai Zhu, Mahmoud A. Mohammad, Simone Di Giacomo, Roshan Borkar, Karthik Reddy Kami Reddy, Mario Capasso, Sanjeev A. Vasudevan, Pavel Sumazin, John Hicks, Nagireddy Putluri, Giovanni Perini, Kristin Eckel-Mahan, Thomas P. Burris, Eveline Barbieri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
MYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neurob
Externí odkaz:
https://doaj.org/article/36f78ce6f76041c49c8161f0733a70f4
Autor:
Emanuela Fanelli, Simone Di Giacomo, Cristina Gambi, Silvia Bianchelli, Zaira Da Ros, Michael Tangherlini, Franco Andaloro, Teresa Romeo, Cinzia Corinaldesi, Roberto Danovaro
Publikováno v:
Biology, Vol 11, Iss 2, p 321 (2022)
The Aeolian Islands (Mediterranean Sea) host a unique hydrothermal system called the “Smoking Land” due to the presence of over 200 volcanic CO2-vents, resulting in water acidification phenomena and the creation of an acidified benthic environmen
Externí odkaz:
https://doaj.org/article/9385133b7b004ba396efdd5008398d72
Autor:
Simone Di Giacomo, Manuela Sollazzo, Dario de Biase, Moira Ragazzi, Paola Bellosta, Annalisa Pession, Daniela Grifoni
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract MYC-mediated cell competition is a cell-cell interaction mechanism known to play an evolutionary role during development from Drosophila to mammals. Cells expressing low levels of MYC, called losers, are committed to die by nearby cells with
Externí odkaz:
https://doaj.org/article/67689ddb725f42bc924694dd326ec759
Autor:
Laura D. Gamble, Stefania Purgato, Michelle J. Henderson, Simone Di Giacomo, Amanda J. Russell, Paolo Pigini, Jayne Murray, Emanuele Valli, Giorgio Milazzo, Federico M. Giorgi, Mark Cowley, Lesley J. Ashton, Jaydutt Bhalshankar, Gudrun Schleiermacher, Ali Rihani, Tom Van Maerken, Jo Vandesompele, Frank Speleman, Rogier Versteeg, Jan Koster, Angelika Eggert, Rosa Noguera, Raymond L. Stallings, Gian Paolo Tonini, Kwun Fong, Zalman Vaksman, Sharon J. Diskin, John M. Maris, Wendy B. London, Glenn M. Marshall, David S. Ziegler, Michael D. Hogarty, Giovanni Perini, Murray D. Norris, Michelle Haber
Publikováno v:
Cancers, Vol 13, Iss 8, p 1807 (2021)
Ornithine decarboxylase (ODC1), a critical regulatory enzyme in polyamine biosynthesis, is a direct transcriptional target of MYCN, amplification of which is a powerful marker of aggressive neuroblastoma. A single nucleotide polymorphism (SNP), G316A
Externí odkaz:
https://doaj.org/article/d53bfb862d414aec9d647c76d3457b58
Autor:
Manuela Sollazzo, China Genchi, Simona Paglia, Simone Di Giacomo, Annalisa Pession, Dario de Biase, Daniela Grifoni
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
The term “field cancerisation” describes the formation of tissue sub-areas highly susceptible to multifocal tumourigenesis. In the earlier stages of cancer, cells may indeed display a series of molecular alterations that allow them to proliferate
Externí odkaz:
https://doaj.org/article/67fa4207c7304ec09eb67f54cce6298e
Autor:
Nagireddy Putluri, Eveline Barbieri, John Hicks, Karthik reddy kami reddy, Pavel Sumazin, Thomas P. Burris, Simone Di Giacomo, Baharan Fekry, Ling Tao, Bokai Zhu, Mario Capasso, Giorgio Milazzo, Giovanni Perini, Sanjeev A. Vasudevan, Myrthala Moreno-Smith, Kristin Eckel-Mahan, Mahmoud A. Mohammad, Roshan Borkar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
nature communications
Nature Communications
nature communications
MYCN activation is a hallmark of advanced neuroblastoma (NB) and a known master regulator of metabolic reprogramming, favoring NB adaptation to its microenvironment. We found that the expression of the main regulators of the molecular clock loops is
Autor:
Cristiana Boi, Francesca Borsetti, Tommaso M. Brugo, Martina Cappelletti, Maria G. De Angelis, Stefano Fedi, Simone Di Giacomo, Thomas Fabiani, Giacomo Foli, Andrea Garelli, Umberto Genchi, Daniele Ghezzi, Chiara Gualandi, Eleonora Lalli, Mirna Magnani, Andrea Maurizzi, Fabio Mazzi, Najmeh Mehrabi, Matteo Minelli, Riccardo Montalbano, Luana Morelli, Silvia Nici, Alessandro Paglianti, Kseniya Papchenko, Sebastiano Pappalardo, Nicola F. Parisi, Riccardo Onesti, Stefania Rapino, Marta Reggio, Marco Roselli, Edoardo Ruggeri, Laura Sabatini, Emanuela Saracino, Giordano E. Scarponi, Lorenzo Serra, Virginia Signorini, Alba Storione, Monica Torsello, Eugenia Tugnoli, Claudia M. Vargiu, Gianluca Vidali, Francesco S. Violante
Publikováno v:
Boi, C, Borsetti, F, Brugo, T M, Cappelletti, M, De Angelis, M G, Fedi, S, Di Giacomo, S, Fabiani, T, Foli, G, Garelli, A, Genchi, U, Ghezzi, D, Gualandi, C, Lalli, E, Magnani, M, Maurizzi, A, Mazzi, F, Mehrabi, N, Minelli, M, Montalbano, R, Morelli, L, Nici, S, Onesti, R, Paglianti, A, Papchenko, K, Pappalardo, S, Parisi, N F, Rapino, S, Reggio, M, Roselli, M, Ruggeri, E, Sabatini, L, Saracino, E, Scarponi, G E, Serra, L, Signorini, V, Storione, A, Torsello, M, Tugnoli, E, Vargiu, C M, Vidali, G & Violante, F S 2022, ' One year of surgical mask testing at the University of Bologna labs : Lessons learned from data analysis ', Separation and Purification Technology, vol. 294, 121180 . https://doi.org/10.1016/j.seppur.2022.121180
The outbreak of SARS-CoV-2 pandemic highlighted the worldwide lack of surgical masks and personal protective equipment, which represent the main defense available against respiratory diseases as COVID-19. At the time, masks shortage was dramatic in I
Cancer has long been regarded and treated as a foreign body appearing by mistake inside a living organism. However, now we know that cancer cells communicate with neighbours, thereby creating modified environments able to support their unusual need f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171df06368f401894ecf6ab27001e817
http://hdl.handle.net/11697/150105
http://hdl.handle.net/11697/150105
Autor:
Rogier Versteeg, Gian Paolo Tonini, Gudrun Schleiermacher, Amanda J. Russell, Angelika Eggert, Murray D. Norris, Jaydutt Bhalshankar, Michael D. Hogarty, Tom Van Maerken, Glenn M. Marshall, Mark J. Cowley, Kwun M. Fong, Lesley J. Ashton, John M. Maris, Sharon J. Diskin, Michelle Haber, Jayne Murray, Michelle J. Henderson, Stefania Purgato, Raymond L. Stallings, Jan Koster, Paolo Pigini, Ali Rihani, Zalman Vaksman, Jo Vandesompele, Wendy B. London, Rosa Noguera, Emanuele Valli, Laura D. Gamble, Franki Speleman, Federico M. Giorgi, Giovanni Perini, Giorgio Milazzo, Simone Di Giacomo, David S. Ziegler
Publikováno v:
Cancers, 13(8):1807. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers
Cancers, Vol 13, Iss 1807, p 1807 (2021)
Volume 13
Issue 8
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
CANCERS
Cancers
Cancers, Vol 13, Iss 1807, p 1807 (2021)
Volume 13
Issue 8
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
CANCERS
Simple Summary Neuroblastoma is a devasting childhood cancer in which multiple copies (amplification) of the cancer-causing gene MYCN strongly predict poor outcome. Neuroblastomas are reliant on high levels of cellular components called polyamines fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4917908fda62bba8644d6ef88dfa1048
https://pure.amc.nl/en/publications/a-g316a-polymorphism-in-the-ornithine-decarboxylase-gene-promoter-modulates-mycndriven-childhood-neuroblastoma(a76771d0-831a-4b04-9af8-31acd810ac62).html
https://pure.amc.nl/en/publications/a-g316a-polymorphism-in-the-ornithine-decarboxylase-gene-promoter-modulates-mycndriven-childhood-neuroblastoma(a76771d0-831a-4b04-9af8-31acd810ac62).html