Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Simone Degen"'
Autor:
Joanna Brzeszczyńska, Angelika Meyer, Robin McGregor, Alain Schilb, Simone Degen, Valentina Tadini, Neil Johns, Ramon Langen, Annemie Schols, David J. Glass, Ronenn Roubenoff, James A. Ross, Kenneth C.H. Fearon, Carolyn A. Greig, Carsten Jacobi
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 1, Pp 93-105 (2018)
Abstract Background Sarcopenia is defined as the age‐related loss of skeletal muscle mass and function. While all humans lose muscle with age, 2–5% of elderly adults develop functional consequences (disabilities). The aim of this study was to inv
Externí odkaz:
https://doaj.org/article/c09f7a587c5642489648c9ba03775860
Autor:
Kristine Pettersen, Sonja Andersen, Simone Degen, Valentina Tadini, Joël Grosjean, Shinji Hatakeyama, Almaz N. Tesfahun, Siver Moestue, Jana Kim, Unni Nonstad, Pål R. Romundstad, Frank Skorpen, Sveinung Sørhaug, Tore Amundsen, Bjørn H. Grønberg, Florian Strasser, Nathan Stephens, Dag Hoem, Anders Molven, Stein Kaasa, Kenneth Fearon, Carsten Jacobi, Geir Bjørkøy
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional status and survival.
Externí odkaz:
https://doaj.org/article/8e2fd60ce44a48aa9b84c81781b5c0b3
Autor:
Neil Johns, Shinji Hatakeyama, Nathan A Stephens, Martin Degen, Simone Degen, Wilfried Frieauff, Christian Lambert, James A Ross, Ronenn Roubenoff, David J Glass, Carsten Jacobi, Kenneth C H Fearon
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83618 (2014)
BACKGROUND: Cachexia affects the majority of patients with advanced cancer and is associated with a reduction in treatment tolerance, response to therapy, and duration of survival. One impediment towards the effective treatment of cachexia is a valid
Externí odkaz:
https://doaj.org/article/137790f226e44fdeb5933e061427f34e
Autor:
Joanna Brzeszczynska, Neil Johns, Simone Degen, Alain Schilb, Ronenn Roubenoff, Carsten Jacobi, Kenneth C. H. Fearon, Angelika Meyer, Carolyn A. Greig, James A. Ross, Robin A. McGregor, David J. Glass, Ramon C. J. Langen, Annemie M. W. J. Schols, Valentina Tadini
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle. 9:93-105
BACKGROUND Sarcopenia is defined as the age-related loss of skeletal muscle mass and function. While all humans lose muscle with age, 2-5% of elderly adults develop functional consequences (disabilities). The aim of this study was to investigate musc
Autor:
Carolyn A. Greig, H. Alexander Ebhardt, Valentina Tadini, Ruedi Aebersold, Simone Degen, Carsten Jacobi, Alain Schilb, Kenneth C. H. Fearon, Neil Johns
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle. 8:567-582
Background Cancer cachexia (cancer-induced muscle wasting) is found in a subgroup of cancer patients leaving the patients with a poor prognosis for survival due to a lower tolerance of the chemotherapeutic drug. The cause of the muscle wasting in the
Autor:
Dag Hoem, Stein Kaasa, Almaz Nigatu Tesfahun, Kenneth C. H. Fearon, Pål Richard Romundstad, Frank Skorpen, Carsten Jacobi, Bjørn Henning Grønberg, Sveinung Sørhaug, Kristine Pettersen, Nathan A. Stephens, Simone Degen, Florian Strasser, Anders Molven, Sonja Andersen, Siver Andreas Moestue, Unni Nonstad, Shinji Hatakeyama, Valentina Tadini, Geir Bjørkøy, Jana Kim, Tore Amundsen, Joel Grosjean
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional status and survival. The under
Autor:
Simone Degen, Ramon C. J. Langen, Joanna Brzeszczynska, Ronenn Roubenoff, Annemie M. W. J. Schols, Martin Degen, Alain Schilb, Kenneth C. H. Fearon, David J. Glass, Neil Johns, Carsten Jacobi, James A. Ross, Carolyn A. Greig
Publikováno v:
Brzeszczynska, J, Johns, N, Schilb, A, Degen, S, Degen, M, Langen, R, Schols, A, Glass, D J, Roubenoff, R, Greig, C A, Jacobi, C, Fearon, K C & Ross, J A 2016, ' Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly ', Aging . https://doi.org/10.18632/aging.101006
Aging (Albany NY)
Aging, 8(8), 1690-1702. Impact Journals LLC
Aging (Albany NY)
Aging, 8(8), 1690-1702. Impact Journals LLC
Muscle wasting in old age or cancer may result from failed myofiber regeneration and/or accelerated atrophy. This study aimed to determine from transcriptomic analysis of human muscle the integrity of the cellular stress response system in relation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3ab69cd0cb1525f50c2d9506cdac0f
https://hdl.handle.net/20.500.11820/e642ed43-e83f-47e6-81a3-63bf7852c830
https://hdl.handle.net/20.500.11820/e642ed43-e83f-47e6-81a3-63bf7852c830
Autor:
Hans-Peter Hohmann, Markus Wyss, Martin Lehmann, Nicholas Schramek, Adelbert Bacher, Simone Degen
Publikováno v:
FEBS Journal. 276:4119-4129
Riboflavin (III, Fig. 1) was discovered 50 years ago by Kuhn and coworkers (1) as an essential vitamin; it is today produced in large quantities industrially, both by chemical synthesis and by fermentation, and is widely used as a food additive and a
Autor:
James A. Ross, Shinji Hatakeyama, Christian Lambert, David J. Glass, Simone Degen, Kenneth C. H. Fearon, Martin Degen, Carsten Jacobi, Wilfried Frieauff, Nathan A. Stephens, Neil Johns, Ronenn Roubenoff
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83618 (2014)
PLoS ONE
Johns, N, Hatakeyama, S, Stephens, N A, Degen, M, Degen, S, Frieauff, W, Lambert, C, Ross, J A, Roubenoff, R, Glass, D J, Jacobi, C & Fearon, K C H 2014, ' Clinical classification of cancer cachexia : phenotypic correlates in human skeletal muscle ', PLoS ONE, vol. 9, no. 1, pp. e83618 . https://doi.org/10.1371/journal.pone.0083618
PLoS ONE
Johns, N, Hatakeyama, S, Stephens, N A, Degen, M, Degen, S, Frieauff, W, Lambert, C, Ross, J A, Roubenoff, R, Glass, D J, Jacobi, C & Fearon, K C H 2014, ' Clinical classification of cancer cachexia : phenotypic correlates in human skeletal muscle ', PLoS ONE, vol. 9, no. 1, pp. e83618 . https://doi.org/10.1371/journal.pone.0083618
BACKGROUND: Cachexia affects the majority of patients with advanced cancer and is associated with a reduction in treatment tolerance, response to therapy, and duration of survival. One impediment towards the effective treatment of cachexia is a valid
Autor:
Martin, Lehmann, Simone, Degen, Hans-Peter, Hohmann, Markus, Wyss, Adelbert, Bacher, Nicholas, Schramek
Publikováno v:
The FEBS journal. 276(15)
GTP cyclohydrolase II catalyzes the first dedicated step in the biosynthesis of riboflavin and appears to be a limiting factor for the production of the vitamin by recombinant Bacillus subtilis overproducer strains. Using error-prone PCR amplificatio