Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Simone Caielli"'
Publikováno v:
Annual Review of Immunology. 41:533-560
Autoreactive B cells and interferons are central players in systemic lupus erythematosus (SLE) pathogenesis. The partial success of drugs targeting these pathways, however, supports heterogeneity in upstream mechanisms contributing to disease pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dceccca3dfdcbd592238dd0672b6b13
https://doi.org/10.1146/annurev-immunol-101921-042422
https://doi.org/10.1146/annurev-immunol-101921-042422
Autor:
Jacqueline S. Gofshteyn, Leanne Mansfield, Jacob Spitznagle, Preetha Balasubramanian, Jacob Cardenas, Thomas Miller, Jinghua Gu, Xuan Wang, Marilynn Punaro, Julie Fuller, Lorien Nassi, Katie Stewart, Marina Ohouo, Cristy Stagnar, Jeanine Baisch, Lynnette Walters, Yuanyuan Wang, Helena Yan, Darawan Rinchai, Damien Chaussabel, Simone Caielli, Seunghee Hong, Karen Onel, Tracey Wright, Virginia Pascual
Publikováno v:
Arthritis & Rheumatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1488ce2746648cc87fb89086ee6084ba
https://doi.org/10.1002/art.42446
https://doi.org/10.1002/art.42446
Autor:
Simone Caielli, Jean-Philippe Blanck, Raphaela Goldbach-Mansky, Julie Fuller, Virginia Pascual, Tracey Wright, Jacques Banchereau, Jeanine Baisch, Katie Stewart, Seunghee Hong, Lorien Nassi, Preetha Balasubramanian, Lynnette Walters, Jinghua Gu, Marina Ohouo, Jacob Cardenas, Cristy Stagnar, Adriana Almeida de Jesus
Publikováno v:
Cell
Nat Immunol
Nat Immunol
Emerging evidence supports that mitochondrial dysfunction contributes to Systemic Lupus Erythematosus (SLE) pathogenesis. Here we show that programmed mitochondrial removal, a hallmark of mammalian erythropoiesis, is defective in SLE. Specifically, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f21a807a857a1761a57a68c92ebfdf
https://europepmc.org/articles/PMC8380737/
https://europepmc.org/articles/PMC8380737/
Autor:
Irina Matei, Virginia Pascual, David Lyden, Fanny A. Pelissier Vatter, Samer Hanna, Ines Castarede, Michele Cioffi, Simone Caielli
Publikováno v:
The Journal of Experimental Medicine
While tumor-derived extracellular vesicles and particles (EVPs) are well characterized, little is known about the cargo and function of immune cell–derived EVPs. Here, we review the functional roles of immune cell–derived EVPs in normal physiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a202087c07ecdccaa2d8721dde7d0f7
https://doi.org/10.1084/jem.20202579
https://doi.org/10.1084/jem.20202579
Autor:
Manjari Chandra, Bojana Domic, Virginia Pascual, Simone Caielli, Lorien Nassi, Cheng-han Chung, Preetha Balasubramanian, Hideki Ueno, Romain Banchereau, Shruti Athale, Julie Fuller, Joseph X. Zhou, Zhaohui Xu, Elise Murat, Tracey Wright, Marilynn Punaro, Diogo Troggian Veiga, Jacques Banchereau, Jeanine Baisch, Duygu Ucar, Katie Stewart, Lynnette Walters
Publikováno v:
Nature Medicine. 25:75-81
Understanding the mechanisms underlying autoantibody development will accelerate therapeutic target identification in autoimmune diseases such as systemic lupus erythematosus (SLE)1. Follicular helper T cells (TFH cells) have long been implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb53836ba623077f89f40f6fd4aa1f8e
https://doi.org/10.1038/s41591-018-0254-9
https://doi.org/10.1038/s41591-018-0254-9
Autor:
Tracey Wright, Simone Caielli, Marina Ohouo, Cindy M Wang, Karen Onel, Seunghee Hong, Yuanyuan Wang, Jeanine Baisch, Virginia Pascual, Natalie Rosenwasser, Peter R. Oxley, Phuong Duc Nguyen, Cynthia Smitherman, Lynnette Walters
Publikováno v:
Poster Presentations.
Background: Children with systemic lupus erythematosus (cSLE) with kidney involvement face considerable morbidity and mortality. Commonly used methods for assessing kidney involvement in cSLE, such as renal function tests, are non-specific and provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::041ef67654bbfaf74700950ee1eaf943
https://doi.org/10.1136/annrheumdis-2019-eular.5241
https://doi.org/10.1136/annrheumdis-2019-eular.5241
Publikováno v:
The Journal of Immunology. 204:230.3-230.3
Understanding the mechanisms underlying how regulatory and pathogenic CD4+ T cells are generated will accelerate therapeutic target identification in autoimmune diseases such as Systemic Lupus Erythematosus (SLE), where this balance is altered. We re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9c686549530aa003c12c4adc1cb0813
https://doi.org/10.4049/jimmunol.204.supp.230.3
https://doi.org/10.4049/jimmunol.204.supp.230.3
Autor:
Jacques Banchereau, Jeanine Baisch, Elise Murat, Marilynn Punaro, Sandra Clayton, Shruti Athale, Cristiana Guiducci, Romain Banchereau, Karolina Palucka, Kate Phelps, Simone Caielli, Tracey Wright, Bojana Domic, Virginia Pascual, Manjari Chandra, Mei Gong
Publikováno v:
The Journal of experimental medicine. 213(5)
Autoantibodies against nucleic acids and excessive type I interferon (IFN) are hallmarks of human systemic lupus erythematosus (SLE). We previously reported that SLE neutrophils exposed to TLR7 agonist autoantibodies release interferogenic DNA, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b683600319a378af11d15ec0cefe1906
https://pubmed.ncbi.nlm.nih.gov/30532021
https://pubmed.ncbi.nlm.nih.gov/30532021
Autor:
Caterina Di Pietro, Cristina Conforti-Andreoni, Maria Luisa Malosio, Simone Caielli, Ester Badami, Vera Usuelli, Marika Falcone
Publikováno v:
The Journal of Immunology. 185:7317-7329
Invariant NKT (iNKT) cells play an effector/adjuvant function during antimicrobial and antitumoral immunity and a regulatory role to induce immune tolerance and prevent autoimmunity. iNKT cells that differentially modulate adaptive immunity do not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3d6a4b80b0795a80336054ec88d8a9
https://doi.org/10.4049/jimmunol.1000400
https://doi.org/10.4049/jimmunol.1000400
Publikováno v:
Current opinion in immunology. 24(6)
Neutrophils have long been known to participate in acute inflammation, but a role in chronic inflammatory and autoimmune diseases is now emerging. These cells are key players in the recognition and elimination of pathogens, but they also sense self c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c10bdcf39141291f598fe85b8d351c4
https://pubmed.ncbi.nlm.nih.gov/23127555
https://pubmed.ncbi.nlm.nih.gov/23127555