Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF–DDX19B interaction

Autor: Kwon Jeong, Leehyeon Kim, Hyun Jung Hwang, Joori Park, Oliver Mühlemann, Simone C. Rufener, Hyun Kyu Song, Yeonkyoung Park, Yoon Ki Kim

Publikováno v: Nucleic Acids Research
Park, Yeonkyoung; Park, Joori; Hwang, Hyun Jung; Kim, Leehyeon; Jeong, Kwon; Song, Hyun Kyu; Rufener, Simone C.; Mühlemann, Oliver; Kim, Yoon Ki (2021). Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF–DDX19B interaction. Nucleic acids research, 49(14), pp. 8261-8276. Oxford University Press 10.1093/nar/gkab579

Newly synthesized mRNA is translated during its export through the nuclear pore complex, when its 5′-cap structure is still bound by the nuclear cap-binding complex (CBC), a heterodimer of cap-binding protein (CBP) 80 and CBP20. Despite its critica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305a87f55891849e07a51edab2029f25
http://europepmc.org/articles/PMC8373075

eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells

Autor: Oliver Mühlemann, Simone C. Rufener

Publikováno v: Nature structural & molecular biology

Eukaryotic mRNAs with premature translation termination codons (PTCs) are recognized and degraded through a process termed nonsense-mediated mRNA decay (NMD). The evolutionary conservation of the core NMD factors UPF1, UPF2 and UPF3 implies a similar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16f8d4410209bfaf288a85998450f44
https://doi.org/10.1038/nsmb.2576