Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF–DDX19B interaction

Autor: Kwon Jeong, Leehyeon Kim, Hyun Jung Hwang, Joori Park, Oliver Mühlemann, Simone C. Rufener, Hyun Kyu Song, Yeonkyoung Park, Yoon Ki Kim

Publikováno v: Nucleic Acids Research
Park, Yeonkyoung; Park, Joori; Hwang, Hyun Jung; Kim, Leehyeon; Jeong, Kwon; Song, Hyun Kyu; Rufener, Simone C.; Mühlemann, Oliver; Kim, Yoon Ki (2021). Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF–DDX19B interaction. Nucleic acids research, 49(14), pp. 8261-8276. Oxford University Press 10.1093/nar/gkab579

Newly synthesized mRNA is translated during its export through the nuclear pore complex, when its 5′-cap structure is still bound by the nuclear cap-binding complex (CBC), a heterodimer of cap-binding protein (CBP) 80 and CBP20. Despite its critica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305a87f55891849e07a51edab2029f25
http://europepmc.org/articles/PMC8373075

Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells

Autor: Christoph Schweingruber, Oliver Mühlemann, Simone C. Rufener, David Zünd, Akio Yamashita

Publikováno v: Europe PubMed Central
Biochimica et biophysica acta

The nonsense-mediated mRNA decay (NMD) pathway is well known as a translation-coupled quality control system that recognizes and degrades aberrant mRNAs with truncated open reading frames (ORF) due to the presence of a premature termination codon (PT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1fbc2d923ac74ca1f93303acb10e6f
https://pubmed.ncbi.nlm.nih.gov/23435113