Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Simone C, Oostindie"'
Autor:
HoChan Cheon, Andrey Kan, Giulio Prevedello, Simone C. Oostindie, Simon J. Dovedi, Edwin D. Hawkins, Julia M. Marchingo, Susanne Heinzel, Ken R. Duffy, Philip D. Hodgkin
Publikováno v:
Frontiers in Bioinformatics, Vol 1 (2021)
Lymphocytes are the central actors in adaptive immune responses. When challenged with antigen, a small number of B and T cells have a cognate receptor capable of recognising and responding to the insult. These cells proliferate, building an exponenti
Externí odkaz:
https://doaj.org/article/584926d25cf74cb9a5207f1222d8115c
Autor:
Hilma J. van der Horst, Simone C. Oostindie, Saskia. A. G. M. Cillessen, Anne T. Gelderloos, Marije B. Overdijk, Inger. S. Nijhof, Sonja Zweegman, Martine E. D. Chamuleau, Esther C. W. Breij, Tuna Mutis
Publikováno v:
HemaSphere, Vol 5, Iss 1, p e504 (2021)
Externí odkaz:
https://doaj.org/article/6d390e89e66241889326e117c149837e
Autor:
Patrick J. Engelberts, Ida H. Hiemstra, Bart de Jong, Danita H. Schuurhuis, Joyce Meesters, Irati Beltran Hernandez, Simone C. Oostindie, Joost Neijssen, Edward N. van den Brink, G. Jean Horbach, Sandra Verploegen, Aran F. Labrijn, Theodora Salcedo, Janine Schuurman, Paul W.H.I Parren, Esther C.W. Breij
Publikováno v:
EBioMedicine, Vol 52, Iss , Pp - (2020)
Background: DuoBody®-CD3xCD20 (GEN3013) is a full-length human IgG1 bispecific antibody (bsAb) recognizing CD3 and CD20, generated by controlled Fab-arm exchange. Its Fc domain was silenced by introduction of mutations L234F L235E D265A. Methods: T-
Externí odkaz:
https://doaj.org/article/8eed60dbcc62461eb9d7224a1bb469dc
Autor:
Simone C. Oostindie, Derek A. Rinaldi, Gijs G. Zom, Michael J. Wester, Desiree Paulet, Kusai Al-Tamimi, Els van der Meijden, Jennifer R. Scheick, Tessa Wilpshaar, Bart de Jong, Marloes Hoff-van den Broek, Rachel M. Grattan, Janita J. Oosterhoff, Julie Vignau, Sandra Verploegen, Peter Boross, Frank J. Beurskens, Diane S. Lidke, Janine Schuurman, Rob N. de Jong
Publikováno v:
Nature Biotechnology. 40:1509-1519
The use of therapeutic monoclonal antibodies is constrained because single antigen targets often do not provide sufficient selectivity to distinguish diseased from healthy tissues. We present HexElect®, an approach to enhance the functional selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37adbdc10c2c7fdd110d991a2ca6fa2f
https://doi.org/10.1038/s41587-022-01384-1
https://doi.org/10.1038/s41587-022-01384-1
Autor:
Simone C. Oostindie, Hilma J. van der Horst, Margaret A. Lindorfer, Erika M. Cook, Jillian C. Tupitza, Clive S. Zent, Richard Burack, Karl R. VanDerMeid, Kristin Strumane, Martine E. D. Chamuleau, Tuna Mutis, Rob N. de Jong, Janine Schuurman, Esther C. W. Breij, Frank J. Beurskens, Paul W. H. I. Parren, Ronald P. Taylor
Publikováno v:
Haematologica, Vol 104, Iss 9 (2019)
CD20 monoclonal antibody therapies have significantly improved the outlook for patients with B-cell malignancies. However, many patients acquire resistance, demonstrating the need for new and improved drugs. We previously demonstrated that the natura
Externí odkaz:
https://doaj.org/article/8951ab20ead14f0a871191432d4962ce
Publikováno v:
Nature Reviews Drug Discovery, 21(10), 715-735. NATURE PORTFOLIO
Antibody function is dependent on avidity - the accumulated strength of multiple affinity interactions between the antibody, antigen, cell surface receptors and other antibodies. In this Review, Oostindie et al. discuss the role of avidity in eliciti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4da7678cb248273fc8dd627179fde8b
https://doi.org/10.1038/s41573-022-00501-8
https://doi.org/10.1038/s41573-022-00501-8
Autor:
Simone C. Oostindie, Mir Farshid Alemdehy, Maarten L. Janmaat, Jenny M. Meerding, Kristel Kemper, Patrick J. Engelberts, Bart E.C.G. De Goeij, David Satijn, A. Kate Sasser, Esther C.W. Breij
Publikováno v:
Blood. 140:3153-3154
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30553f2971d6953cdc08d7b72fc7ec1b
https://doi.org/10.1182/blood-2022-159396
https://doi.org/10.1182/blood-2022-159396
Publikováno v:
Nature reviews. Drug discovery. 21(10)
Antibodies are the cardinal effector molecules of the immune system and are being leveraged with enormous success as biotherapeutic drugs. A key part of the adaptive immune response is the production of an epitope-diverse, polyclonal antibody mixture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dcda6011fd4b83b81c314fbf22a61420
https://pubmed.ncbi.nlm.nih.gov/35790857
https://pubmed.ncbi.nlm.nih.gov/35790857
Autor:
Rob N de Jong, Frank J Beurskens, Sandra Verploegen, Kristin Strumane, Muriel D van Kampen, Marleen Voorhorst, Wendy Horstman, Patrick J Engelberts, Simone C Oostindie, Guanbo Wang, Albert J R Heck, Janine Schuurman, Paul W H I Parren
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002344 (2016)
IgG antibodies can organize into ordered hexamers on cell surfaces after binding their antigen. These hexamers bind the first component of complement C1 inducing complement-dependent target cell killing. Here, we translated this natural concept into
Externí odkaz:
https://doaj.org/article/bfabba60d9884594bbcd39074b399b29
Autor:
Simone C, Oostindie, Derek A, Rinaldi, Gijs G, Zom, Michael J, Wester, Desiree, Paulet, Kusai, Al-Tamimi, Els, van der Meijden, Jennifer R, Scheick, Tessa, Wilpshaar, Bart, de Jong, Marloes, Hoff-van den Broek, Rachel M, Grattan, Janita J, Oosterhoff, Julie, Vignau, Sandra, Verploegen, Peter, Boross, Frank J, Beurskens, Diane S, Lidke, Janine, Schuurman, Rob N, de Jong
Publikováno v:
Nature biotechnology. 40(10)
The use of therapeutic monoclonal antibodies is constrained because single antigen targets often do not provide sufficient selectivity to distinguish diseased from healthy tissues. We present HexElect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f9d47a2d156096e415c018ab095c482
https://pubmed.ncbi.nlm.nih.gov/35879363
https://pubmed.ncbi.nlm.nih.gov/35879363