Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Simone Brusco"'
Autor:
Andrea Balboni, Camilla D’Angelo, Nicoletta Collura, Simone Brusco, Claudia Di Berardino, Altea Targa, Beatrice Massoti, Eloise Mastrangelo, Mario Milani, Pierfausto Seneci, Vania Broccoli, Luca Muzio, Rossella Galli, Andrea Menegon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Glioblastoma (GBM) is the most common malignant primary brain cancer that, despite recent advances in the understanding of its pathogenesis, remains incurable. GBM contains a subpopulation of cells with stem cell-like properties called cance
Externí odkaz:
https://doaj.org/article/d2425d752d414824a5eee89bb1c78547
Autor:
Mattia Zaghi, Federica Banfi, Luca Massimino, Monica Volpin, Edoardo Bellini, Simone Brusco, Ivan Merelli, Cristiana Barone, Michela Bruni, Linda Bossini, Luigi Antonio Lamparelli, Laura Pintado, Deborah D’Aliberti, Silvia Spinelli, Luca Mologni, Gaia Colasante, Federica Ungaro, Jean-Michel Cioni, Emanuele Azzoni, Rocco Piazza, Eugenio Montini, Vania Broccoli, Alessandro Sessa
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Within the chromatin, distal elements interact with promoters to regulate specific transcriptional programs. Histone acetylation, interfering with the net charges of the nucleosomes, is a key player in this regulation. Here, we report that t
Externí odkaz:
https://doaj.org/article/dfd430e45aab49efbf05d9df651f99c5
Autor:
Nicholas Valassina, Simone Brusco, Alessia Salamone, Linda Serra, Mirko Luoni, Serena Giannelli, Simone Bido, Luca Massimino, Federica Ungaro, Pietro Giuseppe Mazzara, Patrizia D’Adamo, Gabriele Lignani, Vania Broccoli, Gaia Colasante
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Dravet syndrome is a devastating epileptic encephalopathy caused by Scn1a gene haploinsufficiency. Exploiting a novel knock-in mouse model, here the authors show that restoring Scn1a expression after symptom onset is sufficient to rescue main phenoty
Externí odkaz:
https://doaj.org/article/32b901a6fa9f4ced99af59fcfd13679d
Autor:
Pietro Giuseppe Mazzara, Sharon Muggeo, Mirko Luoni, Luca Massimino, Mattia Zaghi, Parisa Tajalli-Tehrani Valverde, Simone Brusco, Matteo Jacopo Marzi, Cecilia Palma, Gaia Colasante, Angelo Iannielli, Marianna Paulis, Chiara Cordiglieri, Serena Gea Giannelli, Paola Podini, Cinzia Gellera, Franco Taroni, Francesco Nicassio, Marco Rasponi, Vania Broccoli
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Friedreich’s ataxia (FRDA) is an autosomal-recessive disorder. Here the authors describe a DRG organoid from patient derived-neurons and co-culture with muscle cells to mimic the disorder in vitro and demonstrate potential correction of the phenoty
Externí odkaz:
https://doaj.org/article/b91a2f099cbf40dd993de29571b96be7
Autor:
Zaghi Mattia, Federica Banfi, Luca Massimino, Monica Volpin, Edoardo Bellini, Simone Brusco, Ivan Merelli, Cristiana Barone, Michela Bruni, Linda Bossini, Luigi Antonio Lamparelli, Laura Pintado, Deborah D’Aliberti, Silvia Spinelli, Luca Mologni, Gaia Colasante, Federica Ungaro, Jean-Michel Cioni, Emanuele Azzoni, Rocco Piazza, Eugenio Montini, Vania Broccoli, Alessandro Sessa
Publikováno v:
bioRxiv
SUMMARYWithin the chromatin, distal elements interact with promoters to regulate specific transcriptional programs. Histone acetylation, interfering with the net charges of the nucleosomes, is a key player in this regulation. Here, we report that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51151bb71d99ec37c842c60fd25abfcd
https://doi.org/10.1101/2022.09.12.507599
https://doi.org/10.1101/2022.09.12.507599
Autor:
Sharon Muggeo, Paola Podini, Marianna Paulis, Cecilia Palma, Luca Massimino, Mattia Zaghi, Matteo Jacopo Marzi, Parisa Tajalli Tehrani Valverde, Chiara Cordiglieri, Angelo Iannielli, Pietro Giuseppe Mazzara, Mirko Luoni, Gaia Colasante, Franco Taroni, Francesco Nicassio, Simone Brusco, Serena Giannelli, Cinzia Gellera, Marco Rasponi, Vania Broccoli
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Friedreich’s ataxia (FRDA) is an autosomal-recessive neurodegenerative and cardiac disorder which occurs when transcription of the FXN gene is silenced due to an excessive expansion of GAA repeats into its first intron. Herein, we generate dorsal r
Autor:
Letizia Leocani, Valerio Castoldi, Timothy Church, Raffaele Ricci, Jenna C Carpenter, Claudia Di Berardino, Silvia Marenna, Stephanie Schorge, Gabriele Lignani, Fabio Benfenati, Dimitri M. Kullmann, Gaia Colasante, Luca Massimino, Simone Bido, Vania Broccoli, Simone Brusco, Serena Giannelli, Nicholas Valassina, Giuseppe Morabito
Publikováno v:
Mol Ther
Dravet syndrome (DS) is a severe epileptic encephalopathy caused mainly by heterozygous loss-of-function mutations of the SCN1A gene, indicating haploinsufficiency as the pathogenic mechanism. Here we tested whether catalytically dead Cas9 (dCas9)-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cc44ea332ea26aebe773b0166de647
Autor:
Alida, Amadeo, Aurora, Coatti, Patrizia, Aracri, Miriam, Ascagni, Davide, Iannantuoni, Debora, Modena, Laura, Carraresi, Simone, Brusco, Simone, Meneghini, Annarosa, Arcangeli, Maria Enrica, Pasini, Andrea, Becchetti
Publikováno v:
Neuroscience. 386
The Na
Autor:
Laura Carraresi, Andrea Becchetti, Patrizia Aracri, Maria Enrica Pasini, Simone Brusco, Annarosa Arcangeli, Aurora Coatti, Simone Meneghini, Miriam Ascagni, Debora Modena, Davide Iannantuoni, Alida Amadeo
The Na+/K+/Cl- cotransporter-1 (NKCC1) and the K+/Cl- cotransporter-2 (KCC2) set the transmembrane Cl- gradient in the brain, and are implicated in epileptogenesis. We studied the postnatal distribution of NKCC1 and KCC2 in wild-type (WT) mice, and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3168d200086a94f0b59651c05e8acf5e
http://hdl.handle.net/10281/201123
http://hdl.handle.net/10281/201123
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 6 (2015)
Frontiers in Pharmacology, Vol 6 (2015)
Regulation of the "neuronal" nicotinic acetylcholine receptors (nAChRs) is implicated in both tobacco addiction and smoking-dependent tumor promotion. Some of these effects are caused by the tobacco-derived N-nitrosamines, which are carcinogenic comp