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Autor:
Claudia Mugler, Christian Peschel, Oliver G. Ottmann, Jochen B. Geigl, Rebekka Grundler, Justus Duyster, Cornelius Miething, Michael R. Speicher, J Hoepfl, Simone Brero
Publikováno v:
Proceedings of the National Academy of Sciences. 104:4594-4599
The kinase inhibitor imatinib mesylate targeting the oncoprotein Bcr-Abl has revolutionized the treatment of chronic myeloid leukemia (CML). However, even though imatinib successfully controls the leukemia in chronic phase, it seems not to be able to