Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Simone Bonazzi"'
Autor:
Sameer C. Dhamne, Meera E. Modi, Audrey Gray, Simone Bonazzi, Lucas Craig, Elizabeth Bainbridge, Lahin Lalani, Chloe E. Super, Samantha Schaeffer, Ketthsy Capre, Danuta Lubicka, Guiqing Liang, Doug Burdette, Stephanie M. McTighe, Sarika Gurnani, Sheryl Anne D. Vermudez, Daniel Curtis, Christopher J. Wilson, Mustafa Q. Hameed, Angelica D'Amore, Alexander Rotenberg, Mustafa Sahin
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 10, Pp 1790-1801 (2023)
Abstract Objective Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder caused by autosomal‐dominant pathogenic variants in either the TSC1 or TSC2 gene, and it is characterized by hamartomas in multiple organs, such as skin, kidney, l
Externí odkaz:
https://doaj.org/article/5e6e60c1d4644ed1b4ab20f434f5f54a
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Diversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in the elucidation of novel biological mechanisms. In parallel to the development of
Externí odkaz:
https://doaj.org/article/36c9d05209eb47b1b03cc9fce00df87d
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d2f9e92baa034e31a3064fe3179e5c22
Autor:
Shuang Liu, Bingqi Tong, Jeremy W. Mason, Jonathan M. Ostrem, Antonin Tutter, Bruce K. Hua, Sunny A. Tang, Simone Bonazzi, Karin Briner, Frédéric Berst, Frédéric J. Zécri, Stuart L. Schreiber
Publikováno v:
bioRxiv
The hallmark of a molecular glue is its ability to induce cooperative protein–protein interactions, leading to the formation of a ternary complex, despite weaker binding towards one or both individual proteins. Notably, the extent of cooperativity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf3ad108fb04b6c68686d086e12b440
https://europepmc.org/articles/PMC10245867/
https://europepmc.org/articles/PMC10245867/
Autor:
Jeremy W. Mason, Liam Hudson, Matthias V. Westphal, Antonin Tutter, Gregory Michaud, Wei Shu, Xiaolei Ma, Connor W. Coley, Paul A. Clemons, Simone Bonazzi, Frédéric Berst, Frédéric J. Zécri, Karin Briner, Stuart L. Schreiber
Molecular glues and bifunctional compounds that induce protein–protein associations provide a powerful and general mechanism to modulate cell circuitry. We sought to develop a platform for the direct discovery of compounds able to induce associatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::353823b77fa8f321be337dcdf45df150
https://doi.org/10.1101/2022.10.13.512184
https://doi.org/10.1101/2022.10.13.512184
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Diversity-oriented synthesis (DOS)is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in the elucidation of novel biological mechanisms. In parallel to the development of DOS, DNA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea89009e90b9f024b527255fb7155d39
https://doi.org/10.1101/2022.10.16.512431
https://doi.org/10.1101/2022.10.16.512431
Autor:
Simone Bonazzi, Eva d’Hennezel, Rohan E.J. Beckwith, Lei Xu, Aleem Fazal, Anna Magracheva, Radha Ramesh, Artiom Cernijenko, Brandon Antonakos, Hyo-eun C. Bhang, Roxana García Caro, Jennifer S. Cobb, Elizabeth Ornelas, Xiaolei Ma, Charles A. Wartchow, Matthew C. Clifton, Ry R. Forseth, Bethany Hughes Fortnam, Hongbo Lu, Alfredo Csibi, Jennifer Tullai, Seth Carbonneau, Noel M. Thomsen, Jay Larrow, Barbara Chie-Leon, Dominik Hainzl, Yi Gu, Darlene Lu, Matthew J. Meyer, Dylan Alexander, Jacqueline Kinyamu-Akunda, Catherine A. Sabatos-Peyton, Natalie A. Dales, Frédéric J. Zécri, Rishi K. Jain, Janine Shulok, Y. Karen Wang, Karin Briner, Jeffery A. Porter, John A. Tallarico, Jeffrey A. Engelman, Glenn Dranoff, James E. Bradner, Michael Visser, Jonathan M. Solomon
Publikováno v:
Cell Chemical Biology. 30:235-247.e12
Autor:
Jonathan Solomon, Simone Bonazzi, Eva d'Hennezel, Rohan Beckwith, Lei Xu, Aleem Fazal, Anna Magracheva, Radha Ramesh, Artiom Cernijenko, Brandon Antonakos, Hyo-eun Bhang, Roxana Garcia Caro, Jennifer Cobb, Elizabeth Ornelas, Xiaolei Ma, Charles Wartchow, Matt Clifton, Ry Forseth, Bethany Fortnam, Hongbo Lu, Alfredo Csibi, Jennifer Tullai, Seth Carbonneau, Noel Thomsen, Jay Larrow, Barbara Chie-Leon, Dominik Hainzl, Yi Gu, Darlene Lu, Matthew Meyer, Dylan Alexander, Jacqueline Kinyamu-Akunda, Catherine Sabatos-Peyton, Natalie Dales, Frederic Zecri, Rishi Jain, Janine Shulok, Y. Karen Wang, Karin Briner, Jeffrey Porter, John Tallarico, Jeffrey Engelman, Glenn Dranoff, Jay Bradner, Michael Visser
Growing malignant tumors must evade destruction by the immune system, a hurdle some malignancies overcome by attracting immune-suppressive regulatory T-cells (Tregs)1. The IKZF2 (Helios) transcription factor plays a crucial role in maintaining functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e91b1b99fea2c930f908b107802a0e27
https://doi.org/10.21203/rs.3.rs-1531006/v1
https://doi.org/10.21203/rs.3.rs-1531006/v1
Autor:
Noel Marie-France Thomsen, Simone Bonazzi, Stephanie M. McTighe, Guiqing Liang, Danuta Lubicka, Sarah Salas, Jill Nunez, Franco Lombardo, Rajeshri Ganesh Karki, Audrey Gray, Stefan Peukert, Doug Burdette, Jean-Cosme Dodart, Leon Murphy, Grazia Piizzi, Carleton Goold, Labbe-Giguere Nancy, Erin P. Keaney, Jonathan D. Biag, Christine D. Wilson, Aakruti Gorde, Lawrence G. Hamann, Yingchuan Sun, Lin Deng, Hasnain A. Malik, Daniel Curtis, Shanming Liu
Publikováno v:
Journal of medicinal chemistry. 63(3)
Recent clinical evaluation of everolimus for seizure reduction in patients with tuberous sclerosis complex (TSC), a disease with overactivated mechanistic target of rapamycin (mTOR) signaling, has demonstrated the therapeutic value of mTOR inhibitors
Direct C–H functionalization of aromatic compounds is a useful synthetic strategy that has garnered much attention because of its application to pharmaceuticals, agrochemicals, and late-stage functionalization reactions on complex molecules. On the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1250ba6fc160957b789e64007608a273
https://europepmc.org/articles/PMC5996966/
https://europepmc.org/articles/PMC5996966/