Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Simone Baechler"'
Publikováno v:
Molecular Nutrition & Food Research. 58:1269-1281
Scope Oxidative metabolism of daidzein (DAI) might result in the formation of hydroxylated metabolites. Here, we address the question whether these metabolites differ in their biological activity from the parent isoflavone, exemplified for the epider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078dd86c2696fc535b305056ea1551d4
https://doi.org/10.1002/mnfr.201300531
https://doi.org/10.1002/mnfr.201300531
Autor:
Fritz Boege, Christian Mielke, Doris Marko, Simone Baechler, Markus Fehr, Gudrun Pahlke, Christopher Kropat
Publikováno v:
Mycotoxin Research. 26:247-256
Alternariol (AOH) was reported recently to act as a topoisomerase poison. To underline the relevance of topoisomerase targeting for the genotoxic properties of AOH, we addressed the question whether human tyrosyl-DNA phosphodiesterase 1 (TDP1), an en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2410be77ac2f16033f72790d340f7b13
https://doi.org/10.1007/s12550-010-0063-6
https://doi.org/10.1007/s12550-010-0063-6
Autor:
Almut F. Molzberger, Simone Baechler, Doris Marko, Sebastian T. Soukup, Patrick Diel, Sabine E. Kulling
Publikováno v:
Toxicology letters. 243
The isoflavone genistein has been shown to act as topoisomerase II poison in various cell lines. Here, we address the question whether genistein is able to affect topoisomerase II in vivo. Juvenile male Wistar rats received either a single dose of ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4bcabbb9d7161ea09ef9b2da9f4b49
https://pubmed.ncbi.nlm.nih.gov/26723871
https://pubmed.ncbi.nlm.nih.gov/26723871
Publikováno v:
Journal of agricultural and food chemistry. 62(3)
Grapevine-shoot extracts (GSE), containing trans-resveratrol and resveratrol oligomers, are commercially available as food supplements. Considering the topoisomerase-targeting properties of trans-resveratrol, the question of whether GSE affect these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc122a49fa77b870b83ce5e03288d35
https://pubmed.ncbi.nlm.nih.gov/24369070
https://pubmed.ncbi.nlm.nih.gov/24369070
Autor:
Markus Fehr, Karl-Heinz Merz, Andreas Hofmann, Heinz-Herbert Fiebig, Simone Baechler, Gerhard Eisenbrand, Doris Marko, Michael Habermeyer
Publikováno v:
Bioorganicmedicinal chemistry. 21(3)
The plant alkaloid lycobetaine has potent topoisomerase-targeting properties and shows anticancer activity. Based on these findings, several lycobetaine analogs were synthesized mainly differing in their substituents at 2, 8 and 9 position and their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c740687eadd322b5bc2071c9afa08464
https://pubmed.ncbi.nlm.nih.gov/23266176
https://pubmed.ncbi.nlm.nih.gov/23266176
Autor:
Faiza Kalfalah, Simone Baechler, Doris Marko, Christian Mielke, Fritz Boege, Morten O. Christensen
Publikováno v:
Molecular nutritionfood research. 55
Scope: DNA damage by genistein and etoposide is determined by the half-life of topoisomerase II–DNA linkage induced [Bandele O. J. and Osheroff N., Biochemistry 2008, 47, 11900]. Here, we test whether this applies generally to dietary flavonoids an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08875563339dba1893abb2c8f917baa
https://pubmed.ncbi.nlm.nih.gov/21520487
https://pubmed.ncbi.nlm.nih.gov/21520487
Autor:
Tim Marczylo, Ute Boettler, Andreas J. Gescher, Nicole Teller, Melanie Esselen, Jessica Fritz, Simone Baechler, Doris Marko, Melanie Hutter
Publikováno v:
Molecular nutritionfood research. 55
Scope: The effect of two anthocyanin-rich berry extracts (A, bilberry; B, red grape) on topoisomerases was investigated in a cell-free system and in human HT29 colon carcinoma cells. In parallel, their impact on DNA integrity was determined. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffbb8347031d1ab065b35322bb514ce
https://pubmed.ncbi.nlm.nih.gov/21280204
https://pubmed.ncbi.nlm.nih.gov/21280204
Publikováno v:
Toxicology Letters. 205:S292-S293
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1d888622532dc041a58ddfed0ec9396
https://doi.org/10.1016/j.toxlet.2011.05.989
https://doi.org/10.1016/j.toxlet.2011.05.989