Regulated Transport into the Nucleus of Herpesviridae DNA Replication Core Proteins

Autor: Alessandro Ripalti, Arianna Loregian, Simone Avanzi, Daria Camozzi, David A. Jans, Alvisi Gualtiero, Giorgio Palù

Publikováno v: Viruses, Vol 5, Iss 9, Pp 2210-2234 (2013)

The Herpesvirdae family comprises several major human pathogens belonging to three distinct subfamilies. Their double stranded DNA genome is replicated in the nuclei of infected cells by a number of host and viral products. Among the latter the viral

Externí odkaz: https://doaj.org/article/981be389d9c34667a4966ae0d8f218fb

Nuclear Import of HSV-1 DNA Polymerase Processivity Factor UL42 Is Mediated by a C-Terminally Located Bipartite Nuclear Localization Signal

Autor: Simone Avanzi, Jennifer D. Ly-Huynh, Daria Camozzi, Gualtiero Alvisi, Valerio Leoni, Alessandro Ripalti, Daniele Musiani

Publikováno v: Biochemistry. 47:13764-13777

The polymerase accessory protein of the human herpes simplex virus type 1 (HSV-1) DNA polymerase UL42 plays an essential role in viral replication, conferring processivity to the catalytic subunit UL30. We show here that UL42 is imported to the nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a3decce1046eff58e283b0e9c8a47d
https://doi.org/10.1021/bi800869y

How virus persistence can initiate the tumorigenesis process

Autor: Alessandro Ripalti, Gualtiero Alvisi, Simone Avanzi

Publikováno v: World journal of virology. 2(2)

Human oncogenic viruses are defined as necessary but not sufficient to initiate cancer. Experimental evidence suggests that the oncogenic potential of a virus is effective in cells that have already accumulated a number of genetic mutations leading t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bed213328d79afa345131b86d316652
https://pubmed.ncbi.nlm.nih.gov/24175234

Multiple phosphorylation sites at the C-terminus regulate nuclear import of HCMV DNA polymerase processivity factor ppUL44

Autor: Simone Avanzi, Gregory S. Pari, Oriano Marin, Arianna Loregian, Manuela Mancini, Gualtiero Alvisi, Alessandro Ripalti, David A. Jans

Publikováno v: Virology. 417(2)

The processivity factor of human cytomegalovirus DNA polymerase, phosphoprotein ppUL44, is essential for viral replication. During viral infection ppUL44 is phosphorylated by the viral kinase pUL97, but neither the target residues on ppUL44 nor the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcf2f97672bd79c5612fcb9317ff791
https://pubmed.ncbi.nlm.nih.gov/21741668

How virus persistence can initiate the tumorigenesis process.

Autor: Avanzi S; Simone Avanzi, Alessandro Ripalti, Department of Oncology, Hematology and Laboratory Medicine, Operative Unit of Microbiology, A.O-U. di Bologna Policlinico S. Orsola-Malpighi, 40138 Bologna, Italy., Alvisi G, Ripalti A

Publikováno v: World journal of virology [World J Virol] 2013 May 12; Vol. 2 (2), pp. 102-9.