The Impact of Lipid Handling and Phase Distribution on the Acoustic Behavior of Microbubbles

Autor: Simone A.G. Langeveld, Inés Beekers, Gonzalo Collado-Lara, Antonius F. W. van der Steen, Nico de Jong, Klazina Kooiman

Publikováno v: Pharmaceutics, Vol 13, Iss 1, p 119 (2021)

Phospholipid-coated microbubbles are ultrasound contrast agents that can be employed for ultrasound molecular imaging and drug delivery. For safe and effective implementation, microbubbles must respond uniformly and predictably to ultrasound. Therefo

Externí odkaz: https://doaj.org/article/97073a3afdae4cb5af289b5e25686eb2

Ligand Distribution and Lipid Phase Behavior in Phospholipid-Coated Microbubbles and Monolayers

Autor: Simone A.G. Langeveld, Inés Beekers, Christian Schwieger, Alfred Blume, Tom van Rooij, Jacob Blaffert, Klazina Kooiman

Publikováno v: Langmuir, 36(12), 3221-3233. American Chemical Society
Langmuir

Phospholipid-coated targeted microbubbles are ultrasound contrast agents that can be used for molecular imaging and enhanced drug delivery. However, a better understanding is needed of their targeting capabilities and how they relate to microstructur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab2953b4cf03e88fc6040377d5a0569
https://doi.org/10.1021/acs.langmuir.9b03912

Vancomycin-decorated microbubbles as a theranostic agent for Staphylococcus aureus biofilms

Autor: Joop J.P. Kouijzer, Jean-Marc Strub, Simone A.G. Langeveld, Gaëtan L. A. Mislin, Nico de Jong, Alexander L. Klibanov, Estefania Oliva, Inés Beekers, Antonius F.W. van der Steen, Mariël Leon-Grooters, Willem J. B. van Wamel, Kirby R. Lattwein, Klazina Kooiman

Publikováno v: International Journal of Pharmaceutics, 609
International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2021, pp.121154. ⟨10.1016/j.ijpharm.2021.121154⟩
International Journal of Pharmaceutics, 609:121154. Elsevier
International Journal of Pharmaceutics, 2021, pp.121154. ⟨10.1016/j.ijpharm.2021.121154⟩

Bacterial biofilms are a huge burden on our healthcare systems worldwide. The lack of specificity in diagnostic and treatment possibilities result in difficult-to-treat and persistent infections. The aim of this in vitro study was to investigate if m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d14666516348a52ebe5578bed84fadd
https://pure.eur.nl/en/publications/346ef429-51b2-4e20-9729-f1ba24788191

COMBINED CONFOCAL MICROSCOPE AND BRANDARIS 128 ULTRA-HIGH-SPEED CAMERA

Autor: Simone A.G. Langeveld, Merel Vegter, Kirby R. Lattwein, Rogier Verduyn Lunel, Joop J.P. Kouijzer, Frits Mastik, Klazina Kooiman, Emma Verver, Robert Beurskens, Inés Beekers, Antonius F.W. van der Steen, Nico de Jong

Publikováno v: Ultrasound in Medicine & Biology, 45(9)
Ultrasound in Medicine and Biology, 45(9), 2575-2582. Elsevier Inc.

Controlling microbubble-mediated drug delivery requires the underlying biological and physical mechanisms to be unraveled. To image both microbubble oscillation upon ultrasound insonification and the resulting cellular response, we developed an optic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15660e1d3a445ce5404ab70bde05063b
https://doi.org/10.1016/j.ultrasmedbio.2019.06.004

Engulfed targeted microbubbles: Sonoporation from within theendothelial cell

Autor: Simone A.G. Langeveld, Nico de Jong, Bram Meijlink, Inés Beekers, Antonius F.W. van der Steen, Klazina Kooiman, Martin D. Verweij

Publikováno v: The Journal of the Acoustical Society of America. 149:A118-A118

Targeted microbubbles are currently regarded as objects attached to the outside of the endothelial cell membrane; nonetheless our study shows that microbubbles targeted to the angiogenic biomarker αvβ3 were fully engulfed by the human umbilical vei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac4490687f0a073ebc9ddddce9d73d16
https://doi.org/10.1121/10.0004704