Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Simone A. Nish"'
Autor:
Yen-Hua Chen, Radomir Kratchmarov, Wen-Hsuan W. Lin, Nyanza J. Rothman, Bonnie Yen, William C. Adams, Simone A. Nish, Jeffrey C. Rathmell, Steven L. Reiner
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 860-868 (2018)
Unequal transmission of nutritive signaling during cell division establishes fate disparity between sibling lymphocytes, but how asymmetric signaling becomes organized is not understood. We show that receptor-associated class I phosphatidylinositol 3
Externí odkaz:
https://doaj.org/article/7461fd78f1ed4b0c926b4242d57a9d12
Autor:
William C. Adams, Yen-Hua Chen, Radomir Kratchmarov, Bonnie Yen, Simone A. Nish, Wen-Hsuan W. Lin, Nyanza J. Rothman, Larry L. Luchsinger, Ulf Klein, Meinrad Busslinger, Jeffrey C. Rathmell, Hans-Willem Snoeck, Steven L. Reiner
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3142-3152 (2016)
Regeneration requires related cells to diverge in fate. We show that activated lymphocytes yield sibling cells with unequal elimination of aged mitochondria. Disparate mitochondrial clearance impacts cell fate and reflects larger constellations of op
Externí odkaz:
https://doaj.org/article/5bde382393f64c32b1a85536f31cbaa6
Autor:
Wen-Hsuan W. Lin, Simone A. Nish, Bonnie Yen, Yen-Hua Chen, William C. Adams, Radomir Kratchmarov, Nyanza J. Rothman, Avinash Bhandoola, Hai-Hui Xue, Steven L. Reiner
Publikováno v:
Cell Reports, Vol 17, Iss 7, Pp 1773-1782 (2016)
Selected CD8+ T cells must divide, produce differentiated effector cells, and self-renew, often repeatedly. We now show that silencing expression of the transcription factor TCF1 marks loss of self-renewal by determined effector cells and that this r
Externí odkaz:
https://doaj.org/article/15543fb84dbf457b819749ecac5306c8
Autor:
Wen-Hsuan W. Lin, William C. Adams, Simone A. Nish, Yen-Hua Chen, Bonnie Yen, Nyanza J. Rothman, Radomir Kratchmarov, Takaharu Okada, Ulf Klein, Steven L. Reiner
Publikováno v:
Cell Reports, Vol 13, Iss 10, Pp 2203-2218 (2015)
Metazoan sibling cells often diverge in activity and identity, suggesting links between growth signals and cell fate. We show that unequal transduction of nutrient-sensitive PI3K/AKT/mTOR signaling during cell division bifurcates transcriptional netw
Externí odkaz:
https://doaj.org/article/14178e8238a842baa15557f6ad3eeaef
Publikováno v:
Immunity. 56:687-694
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6e272b25d1aae2caf1fc9ae0c1e55c0
https://doi.org/10.1016/j.immuni.2023.03.015
https://doi.org/10.1016/j.immuni.2023.03.015
Autor:
Nyanza J. Rothman, Ulf Klein, Wen-Hsuan W. Lin, Radomir Kratchmarov, Simone A. Nish, Bonnie Yen, William C. Adams, Steven L. Reiner, Yen-Hua Chen
Publikováno v:
ImmunoHorizons. 1:156-161
Anabolic metabolism in lymphocytes promotes plasmablast and cytotoxic T cell differentiation at the expense of self-renewal. Heightened expression and function of the transcription factor IFN regulatory factor 4 (IRF4) accompany enhanced anabolic ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54646a537204f50c532ebecbccca23f9
https://doi.org/10.4049/immunohorizons.1700012
https://doi.org/10.4049/immunohorizons.1700012
Autor:
Kyra D. Zens, William C. Adams, Nyanza J. Rothman, Wen-Hsuan W. Lin, Yen-Hua Chen, Radomir Kratchmarov, Bonnie Yen, Simone A. Nish, Avinash Bhandoola, Steven L. Reiner, Hai-Hui Xue, Donna L. Farber
Publikováno v:
The Journal of Experimental Medicine
Nish et al. report that production of a fully committed Th1 effector cell occurs during an asymmetric cell division wherein the other daughter cell remains memory cell–like. Unequal transmission of metabolic signaling may be the driver of this rege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b8e4c1b08e18d2b03e04209a238b70
https://doi.org/10.1084/jem.20161046
https://doi.org/10.1084/jem.20161046
Autor:
Ulf Klein, Bonnie Yen, Larry L. Luchsinger, Steven L. Reiner, Yen-Hua Chen, Jeffrey C. Rathmell, Hans-Willem Snoeck, Nyanza J. Rothman, Meinrad Busslinger, Simone A. Nish, William C. Adams, Wen-Hsuan W. Lin, Radomir Kratchmarov
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3142-3152 (2016)
Regeneration requires related cells to diverge in fate. We show that activated lymphocytes yield sibling cells with unequal elimination of aged mitochondria. Disparate mitochondrial clearance impacts cell fate and reflects larger constellations of op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf72c5a4167157aced9f3290e9eda98
http://www.sciencedirect.com/science/article/pii/S2211124716316394
http://www.sciencedirect.com/science/article/pii/S2211124716316394
Autor:
Simone A. Nish, Ulf Klein, William C. Adams, Nyanza J. Rothman, Wen-Hsuan W. Lin, Radomir Kratchmarov, Bonnie Yen, Yen-Hua Chen, Steven L. Reiner
Publikováno v:
ImmunoHorizons
Anabolic metabolism in lymphocytes promotes plasmablast and cytotoxic T cell differentiation at the expense of self-renewal. Heightened expression and function of the transcription factor IFN regulatory factor 4 (IRF4) accompany enhanced anabolic ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa857a43602e21d70061e498aea1aeff
https://pubmed.ncbi.nlm.nih.gov/28944344
https://pubmed.ncbi.nlm.nih.gov/28944344
Autor:
William C. Adams, Simone A. Nish, Hai-Hui Xue, Yen-Hua Chen, Avinash Bhandoola, Wen-Hsuan W. Lin, Steven L. Reiner, Radomir Kratchmarov, Bonnie Yen, Nyanza J. Rothman
Publikováno v:
Cell Reports, Vol 17, Iss 7, Pp 1773-1782 (2016)
SummarySelected CD8+ T cells must divide, produce differentiated effector cells, and self-renew, often repeatedly. We now show that silencing expression of the transcription factor TCF1 marks loss of self-renewal by determined effector cells and that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6614dcd0ca3dc65e9f21078c4d330be3
http://www.sciencedirect.com/science/article/pii/S2211124716314371
http://www.sciencedirect.com/science/article/pii/S2211124716314371