Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Simone A. Douglas"'
Publikováno v:
APL Bioengineering, Vol 4, Iss 4, Pp 046102-046102-12 (2020)
Throughout the process of vascular growth and remodeling, the extracellular matrix (ECM) concurrently undergoes significant changes due to proteolytic activity—regulated by both endothelial and surrounding stromal cells. The role of matrix metallop
Externí odkaz:
https://doaj.org/article/5d53558a39c345e0907278200e8566ad
Autor:
Christian P. Rivera, Edward A. Botchwey, Manu O. Platt, Simone A. Douglas, Abhiramgopal Akella, Jada M. Selma, Nishone Thompson, Hannah Song, Keval Bollavaram
Publikováno v:
Blood Advances. 6:1381-1393
Sickle cell disease (SCD) is the most common hereditary blood disorder in the United States. SCD is frequently associated with osteonecrosis, osteoporosis, osteopenia, and other bone-related complications such as vaso-occlusive pain, ischemic damage,
Publikováno v:
APL Bioengineering
APL Bioengineering, Vol 4, Iss 4, Pp 046102-046102-12 (2020)
APL Bioengineering, Vol 4, Iss 4, Pp 046102-046102-12 (2020)
Throughout the process of vascular growth and remodeling, the extracellular matrix (ECM) concurrently undergoes significant changes due to proteolytic activity—regulated by both endothelial and surrounding stromal cells. The role of matrix metallop
Autor:
Simone A. Douglas, Dayne M. West, Meghan C. Ferrall-Fairbanks, Manu O. Platt, Rodney D. Averett
Publikováno v:
Protein Science. 27:714-724
Fibrin clot formation is a proteolytic cascade of events with thrombin and plasmin identified as the main proteases cleaving fibrinogen precursor, and the fibrin polymer, respectively. Other proteases may be involved directly in fibrin(ogen) cleavage
Publikováno v:
Chemical & Engineering News. :66-67
Publikováno v:
C&EN Global Enterprise. 99:66-67
Autor:
Sarah E. Lamothe, Manu O. Platt, Simone A. Douglas, Rodney D. Averett, Tatiyanna S. Singleton
Background Fibrin formation and dissolution are attributed to cascades of protease activation concluding with thrombin activation, and plasmin proteolysis for fibrin breakdown. Cysteine cathepsins are powerful proteases secreted by endothelial cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd231ec42b380de51bb16939f1b0e7e
https://europepmc.org/articles/PMC6114084/
https://europepmc.org/articles/PMC6114084/
Sickle cell disease is caused by the amino acid substitution of glutamic acid to valine, which leads to the polymerization of deoxygenated sickle hemoglobin (HbS) into long strands. These strands are responsible for the sickling of red blood cells (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4894a2fc64a384195afd143396c4aa
https://europepmc.org/articles/PMC6918955/
https://europepmc.org/articles/PMC6918955/
Autor:
Sarah E. Lamothe, Rodney D. Averett, Manu O. Platt, Simone A. Douglas, Tatiyanna S. Singleton
Publikováno v:
The FASEB Journal. 32
Autor:
Simone A. Douglas, Kara E. McCloskey, Nicole Madfis, Yuhong Fan, Ashwath Kumar, Zhiqiang Lin, Manu O. Platt
Publikováno v:
Stem cells and development, vol 27, iss 5
A well-formed and robust vasculature is critical to the health of most organ systems in the body. However, the endothelial cells (ECs) forming the vasculature can exhibit a number of distinct functional subphenotypes like arterial or venous ECs, as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b9ac20ff2c0c24d67866cde1adcf7c
https://escholarship.org/uc/item/1vs7r01m
https://escholarship.org/uc/item/1vs7r01m