Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Simone A, Walker"'
Autor:
Silvia A. Ferreira, Francesca Tallia, Agathe Heyraud, Simone A. Walker, Christoph Salzlechner, Julian R. Jones, Sara M. Rankin
Publikováno v:
Biomaterials and Biosystems, Vol 13, Iss , Pp 100087- (2024)
Biomaterials that can improve the healing of articular cartilage lesions are needed. To address this unmet need, we developed novel 3D printed silica/poly(tetrahydrofuran)/poly(ε-caprolactone) (SiO2/PTHF/PCL-diCOOH) hybrid scaffolds. Our aim was to
Externí odkaz:
https://doaj.org/article/37901c22149349c8ae3d60e1192e0ba6
Autor:
Richard J. Hewitt, Franz Puttur, David C. A. Gaboriau, Frédéric Fercoq, Maryline Fresquet, William J. Traves, Laura L. Yates, Simone A. Walker, Philip L. Molyneaux, Samuel V. Kemp, Andrew G. Nicholson, Alexandra Rice, Edward Roberts, Rachel Lennon, Leo M. Carlin, Adam J. Byrne, Toby M. Maher, Clare M. Lloyd
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Aberrant expansion of KRT5+ basal cells in the distal lung accompanies progressive alveolar epithelial cell loss and tissue remodelling during fibrogenesis in idiopathic pulmonary fibrosis (IPF). The mechanisms determining activity of KRT5+
Externí odkaz:
https://doaj.org/article/c6117e8de91842c6bbf2409cf0b50247
Autor:
Thanushiyan Poobalasingam, Laura L. Yates, Simone A. Walker, Miguel Pereira, Nina Y. Gross, Akmol Ali, Maria Kolatsi-Joannou, Marjo-Riitta Jarvelin, Juha Pekkanen, Eugenia Papakrivopoulou, David A. Long, Mark Griffiths, Darcy Wagner, Melanie Königshoff, Matthew Hind, Cosetta Minelli, Clare M. Lloyd, Charlotte H. Dean
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 4, Pp 409-423 (2017)
Lung diseases impose a huge economic and health burden worldwide. A key aspect of several adult lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD), including emphysema, is aberrant tissue repai
Externí odkaz:
https://doaj.org/article/737a3559ebf7460ea9a148eaddafbd89
Autor:
Régis Joulia, Franz Puttur, Helen Stölting, Lewis J. Entwistle, Anna Voitovich, May Al-Sahaf, Katie Bonner, Elizabeth Scotney, Philip L Molyneaux, Richard J Hewitt, Simone A. Walker, Laura Yates, Sejal Saglani, Clare M. Lloyd
SummaryAllergic asthma generally starts during early life and is linked to significant tissue remodelling and lung dysfunction. Although angiogenesis is a feature of the disrupted airway, the impact of allergic asthma on the pulmonary microcirculatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e0b62c7d3b6d1f7f5422e8d64aa3b6
https://doi.org/10.1101/2023.03.07.529253
https://doi.org/10.1101/2023.03.07.529253
Autor:
Richard J. Hewitt, Franz Puttur, David C. A. Gaboriau, Frédéric Fercoq, Maryline Fresquet, William J. Traves, Laura L. Yates, Simone A. Walker, Philip L. Molyneaux, Samuel V. Kemp, Andrew G. Nicholson, Alexandra Rice, Rachel Lennon, Leo M. Carlin, Adam J. Byrne, Toby M. Maher, Clare M. Lloyd
Aberrant expansion of KRT5+basal cells in the distal lung accompanies progressive alveolar epithelial cell loss and tissue remodelling during fibrogenesis in idiopathic pulmonary fibrosis (IPF). The mechanisms determining activity of KRT5+cells in IP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb459570fb19996ca83f848dc3537ed1
https://doi.org/10.1101/2022.12.16.520808
https://doi.org/10.1101/2022.12.16.520808
Autor:
Youming Zhang, Thanushiyan Poobalasingam, Laura L. Yates, Simone A. Walker, Martin S. Taylor, Lauren Chessum, Jackie Harrison, Loukia Tsaprouni, Ian M. Adcock, Clare M. Lloyd, William O. Cookson, Miriam F. Moffatt, Charlotte H. Dean
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 1 (2018)
We previously identified dipeptidylpeptidase 10 (DPP10) on chromosome 2 as a human asthma susceptibility gene, through positional cloning. Initial association results were confirmed in many subsequent association studies but the functional role of DP
Externí odkaz:
https://doaj.org/article/67ed6d54a0234aaa8bc3fcd1b739bff4
Autor:
Clare M. Lloyd, Simone A. Walker, Robert A. Oliver, James Cook, Anne O'Garra, Nicoletta Bruno, Sejal Saglani, Helen Stölting, William J. Branchett, Matthias Mack
Publikováno v:
The Journal of Allergy and Clinical Immunology
Background Early life represents a major risk window for asthma development. However, the mechanisms controlling the threshold for establishment of allergic airway inflammation in early life are incompletely understood. Airway macrophages (AMs) regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611fb2a95f706e51bb7280f80ae39d5b
https://doi.org/10.1016/j.jaci.2021.01.026
https://doi.org/10.1016/j.jaci.2021.01.026
Publikováno v:
Airway cell biology and immunopathology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75f786171bef25c678c52a93853729a8
https://doi.org/10.1183/13993003.congress-2021.pa871
https://doi.org/10.1183/13993003.congress-2021.pa871
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2285
Asthma is a highly prevalent lung disease, characterized by airway dysfunction and chronic inflammation. Asthma occurs in both children and adults, but frequently originates in early life. Heterogeneous asthma phenotypes exist, but Th2 cells are key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::166303a4b251cc4d6b412549086f8899
https://pubmed.ncbi.nlm.nih.gov/33928563
https://pubmed.ncbi.nlm.nih.gov/33928563
Publikováno v:
03.02 - Airway cell biology and immunopathology.
Lung function deficits established in asthmatic children persist into adulthood, but the mechanisms are not well understood. Airway remodelling is a key pathological feature of paediatric and adult asthma and may contribute to loss of lung function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99975b0716792e9ecb2796c34d8fbbe4
https://doi.org/10.1183/23120541.lsc-2021.19
https://doi.org/10.1183/23120541.lsc-2021.19