Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Simone A, Baechler"'
Autor:
Yilun Sun, Simone A. Baechler, Xiaohu Zhang, Suresh Kumar, Valentina M. Factor, Yasuhiro Arakawa, Cindy H. Chau, Kanako Okamoto, Anup Parikh, Bob Walker, Yijun P. Su, Jiji Chen, Tabitha Ting, Shar-yin N. Huang, Erin Beck, Zina Itkin, Crystal McKnight, Changqing Xie, Nitin Roper, Deepak Nijhawan, William Douglas Figg, Paul S. Meltzer, James C. Yang, Craig J. Thomas, Yves Pommier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and NEDD8 is synergistically cytotoxic in human CRC cells.
Externí odkaz:
https://doaj.org/article/9bbad19d5fd14d8c895c04b8d779aa1f
Autor:
Jonathan R. Brody, Dan A. Dixon, Pankaj K. Singh, Joseph Salvino, George C. Prendergast, Emanuel F. Petricoin, Charles J. Yeo, Talia Golan, Michael J. Pishvaian, Simone A. Baechler, Yves Pommier, Hoora Shaghaghi, Ross Summer, Joel Cassel, Ranjan Preet, Dezhen Wang, Vikalp Vishwakarma, Valerie S. Calvert, Aditi Jain, Austin Goetz, Samantha Z. Brown, Wei Jiang, Matthew D. McCoy, James B. DuHadaway, Avinoam Nevler, Teena Nerwal, Grace A. McCarthy, Christopher W. Schultz
All supplemental figures tables and legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055baf8399461fbb5ea91fd729dad359
https://doi.org/10.1158/1535-7163.22521855.v1
https://doi.org/10.1158/1535-7163.22521855.v1
Autor:
Jonathan R. Brody, Dan A. Dixon, Pankaj K. Singh, Joseph Salvino, George C. Prendergast, Emanuel F. Petricoin, Charles J. Yeo, Talia Golan, Michael J. Pishvaian, Simone A. Baechler, Yves Pommier, Hoora Shaghaghi, Ross Summer, Joel Cassel, Ranjan Preet, Dezhen Wang, Vikalp Vishwakarma, Valerie S. Calvert, Aditi Jain, Austin Goetz, Samantha Z. Brown, Wei Jiang, Matthew D. McCoy, James B. DuHadaway, Avinoam Nevler, Teena Nerwal, Grace A. McCarthy, Christopher W. Schultz
Pancreatic ductal adenocarcinoma (PDAC) is a lethal aggressive cancer, in part due to elements of the microenvironment (hypoxia, hypoglycemia) that cause metabolic network alterations. The FDA-approved antihelminthic pyrvinium pamoate (PP) has previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337adb63a7d3d635f687dfa23f98e4cc
https://doi.org/10.1158/1535-7163.c.6543201
https://doi.org/10.1158/1535-7163.c.6543201
Cancer/Testis Antigen 55 is required for cancer cell proliferation and mitochondrial DNA maintenance
Autor:
Jade Aurrière, David Goudenege, Simone A. Baechler, Shar-Yin N. Huang, Naig Gueguen, Valerie Desquiret-Dumas, Floris Chabrun, Rodolphe Perrot, Arnaud Chevrollier, Majida Charif, Olivier R Baris, Yves Pommier, Guy Lenaers, Salim Khiati
Publikováno v:
Mitochondrion
Cancer/Testis Antigens (CTAs) represent a group of proteins whose expression under physiological conditions is restricted to testis but activated in many human cancers. Also, it was observed that co-expression of multiple CTAs worsens the patient pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4445dd0759229db7bb393ef2f5aad4df
https://europepmc.org/articles/PMC9057655/
https://europepmc.org/articles/PMC9057655/
Publikováno v:
Cell Cycle
Mitochondria contain their own genome (mtDNA), encoding 13 proteins of the enzyme complexes of the oxidative phosphorylation. Synthesis of these 13 mitochondrial proteins requires a specific translation machinery, the mitoribosomes whose RNA componen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09dcf2dc4e95e6d9188577cff2084948
https://doi.org/10.1080/15384101.2019.1646563
https://doi.org/10.1080/15384101.2019.1646563
Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5
Autor:
Sourav Saha, Xi Yang, Shar-yin Naomi Huang, Keli Agama, Simone Andrea Baechler, Yilun Sun, Hongliang Zhang, Liton Kumar Saha, Shuaikun Su, Lisa M. Jenkins, Weidong Wang, Yves Pommier
Publikováno v:
Cell Reports. 40:111067
The present study demonstrates how TOP3B is involved in resolving R-loops. We observed elevated R-loops in TOP3B knockout cells (TOP3BKO), which are suppressed by TOP3B transfection. R-loop-inducing agents, the topoisomerase I inhibitor camptothecin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1d0d2e57ff6b9a5c08ca4a859b3139
https://doi.org/10.1016/j.celrep.2022.111067
https://doi.org/10.1016/j.celrep.2022.111067
Autor:
Dan A. Dixon, Talia Golan, James B. DuHadaway, Teena Nerwal, Austin Goetz, Simone A Baechler, Yves Pommier, Avinoam Nevler, Michael J. Pishvaian, Emanuel F. Petricoin, Charles J. Yeo, Valerie S. Calvert, Pankaj K. Singh, Christopher W. Schultz, Joel Cassel, Wei Jiang, Dezhen Wang, Vikalp Vishwakarma, Aditi Jain, Matthew McCoy, Grace A. McCarthy, Joseph M. Salvino, Ranjan Preet, George C. Prendergast, Samantha Z Brown, Ross Summer, Hoorah Shaghaghi, Jonathan R. Brody
Publikováno v:
Mol Cancer Ther
Pancreatic ductal adenocarcinoma (PDAC) is a lethal aggressive cancer, in part due to elements of the microenvironment (hypoxia, hypoglycemia) that cause metabolic network alterations. The FDA-approved antihelminthic pyrvinium pamoate (PP) has previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9bc4613441099e4e1eb4de43e5058ba
https://pubmed.ncbi.nlm.nih.gov/34413127
https://pubmed.ncbi.nlm.nih.gov/34413127
Autor:
Simone A Baechler, Antonella Spinazzola, Stephanie A. Michaels, Salim Khiati, Valentina M. Factor, L. M. Miller Jenkins, A. Ravji, Leonard M. Neckers, I. Dalla Rosa, Shar-yin N. Huang, Carole Sourbier, Yves Pommier, Hongzhi Zhang, Jens U. Marquardt, D. Becker, Martin Lang
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10, pp.83. ⟨10.1038/s41467-018-07922-3⟩
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications, Nature Publishing Group, 2019, 10, pp.83. ⟨10.1038/s41467-018-07922-3⟩
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Mitochondrial topoisomerase IB (TOP1MT) is a nuclear-encoded topoisomerase, exclusively localized to mitochondria, which resolves topological stress generated during mtDNA replication and transcription. Here, we report that TOP1MT is overexpressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c73dbf6e5c74905365abc44ca43524
https://hal.archives-ouvertes.fr/hal-02086952
https://hal.archives-ouvertes.fr/hal-02086952
Autor:
Simone A Baechler, Sourav Saha, Keli Agama, Yves Pommier, Shar-yin Naomi Huang, Yuk-Ching Tse-Dinh, Hongliang Zhang, Yilun Sun, Ukhyun Jo, Lorinc Pongor
Publikováno v:
Cell reports
SUMMARY The present study demonstrates that topoisomerase 3B (TOP3B) forms both RNA and DNA cleavage complexes (TOP3Bccs) in vivo and reveals a pathway for repairing TOP3Bccs. For inducing and detecting cellular TOP3Bccs, we engineer a “self-trappi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0f4bf3bc38d9b015d0145b7ea9ecc8
http://europepmc.org/articles/PMC7859927
http://europepmc.org/articles/PMC7859927
Autor:
Ilaria Dalla Rosa, Stephanie A. Michaels, Keli Agama, Simone A Baechler, Lisa M. Miller Jenkins, Salim Khiati, Valentina M. Factor, Yves Pommier, Shar-yin N. Huang, Sae Rin Jean, David V. Tulumello, Sudhir Varma, Junko Murai, Shana O. Kelley
Publikováno v:
EMBO Reports
EMBO Reports, EMBO Press, 2018, 19 (3), pp.e42139. ⟨10.15252/embr.201642139⟩
EMBO Reports, EMBO Press, 2018, 19 (3), pp.e42139. ⟨10.15252/embr.201642139⟩
Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs abortive topoisomerase II cleavage complexes. Here, we identify a novel short isoform of TDP2 (TDP2S) expressed from an alternative transcription start site. TDP2S contains a mitochondrial targeting sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c105ffa143075ed5117c15840bee30f9
https://doi.org/10.15252/embr.201642139
https://doi.org/10.15252/embr.201642139