Zobrazeno 1 - 10
of 545
pro vyhledávání: '"Simone Fulda"'
This book will be focused on mitochondria as very promising targets for anti-cancer drugs, yet to be fully exploited. It will contain chapters focused on aspects of basic research as well as on clinical relevance, which will be written by specialists
Autor:
Ulvi Ahmadov, Daniel Picard, Jasmin Bartl, Manuela Silginer, Marija Trajkovic-Arsic, Nan Qin, Lena Blümel, Marietta Wolter, Jonathan K. M. Lim, David Pauck, Alina Marie Winkelkotte, Marlen Melcher, Maike Langini, Viktoria Marquardt, Felix Sander, Anja Stefanski, Sascha Steltgens, Christina Hassiepen, Anna Kaufhold, Frauke-Dorothee Meyer, Annette Seibt, Lara Kleinesudeik, Anika Hain, Carsten Münk, Christiane Brigitte Knobbe-Thomsen, Alexander Schramm, Ute Fischer, Gabriel Leprivier, Kai Stühler, Simone Fulda, Jens T. Siveke, Felix Distelmaier, Arndt Borkhardt, Michael Weller, Patrick Roth, Guido Reifenberger, Marc Remke
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-11 (2021)
Abstract Glioblastoma is the most common malignant primary brain tumor. To date, clinically relevant biomarkers are restricted to isocitrate dehydrogenase (IDH) gene 1 or 2 mutations and O6-methylguanine DNA methyltransferase (MGMT) promoter methylat
Externí odkaz:
https://doaj.org/article/7af56daa21a545719f08c431620aa3e9
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010383 (2022)
The paper describes a mathematical model of the molecular switches of cell survival, apoptosis, and necroptosis in cellular signaling pathways initiated by tumor necrosis factor 1. Based on experimental findings in the literature, we constructed a Pe
Externí odkaz:
https://doaj.org/article/cc3f8093f4194e55801bbdf7fea54cb6
Autor:
Annkathrin Koch, Birte Jeiler, Jens Roedig, Sjoerd J.L. van Wijk, Nadezda Dolgikh, Simone Fulda
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 5, Pp 539-550 (2021)
Burkitt's lymphoma (BL) is a highly aggressive form of B-cell non-Hodgkin's lymphoma. The clinical outcome in children with BL has improved over the last years but the prognosis for adults is still poor, highlighting the need for novel treatment stra
Externí odkaz:
https://doaj.org/article/746d29e524ac4212a6dfac6ce63571a4
Autor:
Anne-Kathrin Knuth, Stefanie Rösler, Barbara Schenk, Lisa Kowald, Sjoerd J.L. van Wijk, Simone Fulda
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 1, Pp 74-81 (2019)
Interferons (IFNs) are key players in the tumor immune response and act by inducing the expression of IFN-stimulated genes (ISGs). Here, we identify the mixed-lineage kinase domain-like pseudokinase (MLKL) as an ISG in various cancer cell lines. Both
Externí odkaz:
https://doaj.org/article/9bf0ec570bf74f28abe3cca90f4d20db
Autor:
Victoria M. Smith, Anna Dietz, Kristina Henz, Daniela Bruecher, Ross Jackson, Lisa Kowald, Sjoerd J.L. van Wijk, Sandrine Jayne, Salvador Macip, Simone Fulda, Martin J.S. Dyer, Meike Vogler
Publikováno v:
Haematologica, Vol 105, Iss 8 (2020)
The BCL-2-specific inhibitor, ABT-199 (venetoclax) has exhibited remarkable clinical activity in nearly all cases of chronic lymphocytic leukemia. In contrast, responses are usually much less in diffuse large B-cell lymphoma (DLBCL), despite high lev
Externí odkaz:
https://doaj.org/article/319ce7a40074445598d5e3c9e2f33b2f
Publikováno v:
Translational Oncology, Vol 13, Iss 8, Pp 100785- (2020)
Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepat
Externí odkaz:
https://doaj.org/article/9e3161af1628415ba467cab9addcade4
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244060 (2020)
Ataxia-Telangiectasia (A-T), a pleiotropic chromosomal breakage syndrome, is caused by the loss of the kinase Ataxia-telangiectasia mutated (ATM). ATM is not only involved in the response to DNA damage, but also in sensing and counteracting oxidative
Externí odkaz:
https://doaj.org/article/f812e193065e4820b2f736613860119d
Autor:
Denise Haslinger, Regina Waltes, Afsheen Yousaf, Silvia Lindlar, Ines Schneider, Chai K. Lim, Meng-Miao Tsai, Boyan K. Garvalov, Amparo Acker-Palmer, Nicolas Krezdorn, Björn Rotter, Till Acker, Gilles J. Guillemin, Simone Fulda, Christine M. Freitag, Andreas G. Chiocchetti
Publikováno v:
Molecular Autism, Vol 9, Iss 1, Pp 1-17 (2018)
Abstract Background Altered neuronal development is discussed as the underlying pathogenic mechanism of autism spectrum disorders (ASD). Copy number variations of 16p11.2 have recurrently been identified in individuals with ASD. Of the 29 genes withi
Externí odkaz:
https://doaj.org/article/ce0cb06f639d43dd818685fcf52ff225
Autor:
Susanne A. Gatz, Ewa Aladowicz, Michela Casanova, Julia C. Chisholm, Pamela R. Kearns, Simone Fulda, Birgit Geoerger, Beat W. Schäfer, Janet M. Shipley
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Rhabdomyosarcomas are the most common pediatric soft tissue sarcoma and are a major cause of death from cancer in young patients requiring new treatment options to improve outcomes. High-risk patients include those with metastatic or relapsed disease
Externí odkaz:
https://doaj.org/article/4fc4f77910684cc7bfb2bc64c293d211