Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Simone, Wahl"'
Autor:
Johann S. Hawe, Ashis Saha, Melanie Waldenberger, Sonja Kunze, Simone Wahl, Martina Müller-Nurasyid, Holger Prokisch, Harald Grallert, Christian Herder, Annette Peters, Konstantin Strauch, Fabian J. Theis, Christian Gieger, John Chambers, Alexis Battle, Matthias Heinig
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-21 (2022)
Abstract Background Molecular measurements of the genome, the transcriptome, and the epigenome, often termed multi-omics data, provide an in-depth view on biological systems and their integration is crucial for gaining insights in complex regulatory
Externí odkaz:
https://doaj.org/article/2b13b5fffc9f422591ea72ddca8001f6
Publikováno v:
BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background Diagnostic accuracy studies aim to examine the diagnostic accuracy of a new experimental test, but do not address the actual merit of the resulting diagnostic information to a patient in clinical practice. In order to assess the i
Externí odkaz:
https://doaj.org/article/31c12c862b8f46c8879af494ab5f684b
Autor:
Juan Jose Carmona, Richard T. Barfield, Tommaso Panni, Jamaji C. Nwanaji-Enwerem, Allan C. Just, John N. Hutchinson, Elena Colicino, Stefan Karrasch, Simone Wahl, Sonja Kunze, Nadereh Jafari, Yinan Zheng, Lifang Hou, Dawn L. DeMeo, Augusto A. Litonjua, Pantel S. Vokonas, Annette Peters, Xihong Lin, Joel Schwartz, Holger Schulz, Andrea A. Baccarelli
Publikováno v:
Epigenetics, Vol 13, Iss 10-11, Pp 1039-1055 (2018)
DNA methylation is an epigenetic regulator of gene transcription, which has been found to be both metastable and variable within human cohort studies. Currently, few studies have been done to identify metastable DNA methylation biomarkers associated
Externí odkaz:
https://doaj.org/article/5d9982f725de4eee995fef75e29b36f8
Autor:
Eline A.J. Willemse, Ingrid S. vanMaurik, Betty M. Tijms, Femke H. Bouwman, Andreas Franke, Isabelle Hubeek, Leo Boelaarts, Jules J. Claus, Esther S.C. Korf, Rob J. vanMarum, Gerwin Roks, Niki Schoonenboom, Nicolaas Verwey, Marissa D. Zwan, Simone Wahl, Wiesje M. van derFlier, Charlotte E. Teunissen
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 563-572 (2018)
Abstract Introduction We compared the automated Elecsys and manual Innotest immunoassays for cerebrospinal fluid (CSF) Alzheimer's disease biomarkers in a multicenter diagnostic setting. Methods We collected CSF samples from 137 participants in eight
Externí odkaz:
https://doaj.org/article/910a06b0ba9b49ccbb4aec17c7a9ec5b
Autor:
Leslie M. Shaw, Teresa Waligorska, Leona Fields, Magdalena Korecka, Michal Figurski, John Q. Trojanowski, Udo Eichenlaub, Simone Wahl, Marian Quan, Michael J. Pontecorvo, D. Richard Lachno, Jayne A. Talbot, Scott W. Andersen, Eric R. Siemers, Robert A. Dean
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 698-705 (2018)
Abstract Introduction An Elecsys® Amyloid β (Aβ [1–42]) immunoassay cutoff for classification of patients with Alzheimer's disease was investigated. Methods Cerebrospinal fluid samples collected from patients with mild‐to‐moderate Alzheimer'
Externí odkaz:
https://doaj.org/article/bc35f0e3552b41acbe1dcbd426ecd5fb
Autor:
Rory Wilson, Simone Wahl, Liliane Pfeiffer, Cavin K. Ward-Caviness, Sonja Kunze, Anja Kretschmer, Eva Reischl, Annette Peters, Christian Gieger, Melanie Waldenberger
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background The evidence for epigenome-wide associations between smoking and DNA methylation continues to grow through cross-sectional studies. However, few large-scale investigations have explored the associations using observations for indi
Externí odkaz:
https://doaj.org/article/5676f861fd9d4b19840d76959a9f74ff
Autor:
Sophie Molnos, Clemens Baumbach, Simone Wahl, Martina Müller-Nurasyid, Konstantin Strauch, Rui Wang-Sattler, Melanie Waldenberger, Thomas Meitinger, Jerzy Adamski, Gabi Kastenmüller, Karsten Suhre, Annette Peters, Harald Grallert, Fabian J. Theis, Christian Gieger
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-8 (2017)
Abstract Background Genome-wide association studies allow us to understand the genetics of complex diseases. Human metabolism provides information about the disease-causing mechanisms, so it is usual to investigate the associations between genetic va
Externí odkaz:
https://doaj.org/article/5050b8deacdc406baf1a8ec8049548a9
Autor:
Susanne Jäger, Simone Wahl, Janine Kröger, Sapna Sharma, Per Hoffmann, Anna Floegel, Tobias Pischon, Cornelia Prehn, Jerzy Adamski, Martina Müller-Nurasyid, Melanie Waldenberger, Konstantin Strauch, Annette Peters, Christian Gieger, Karsten Suhre, Harald Grallert, Heiner Boeing, Matthias B. Schulze, Karina Meidtner
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Diabetes-associated metabolites may aid the identification of new risk variants for type 2 diabetes. Using targeted metabolomics within a subsample of the German EPIC-Potsdam study (n = 2500), we tested previously published SNPs for their as
Externí odkaz:
https://doaj.org/article/0abb98fcb66d4e54a7531e7e047fa972
Autor:
Hartmut Heinrich, Juliane Grunitz, Valeska Stonawski, Stefan Frey, Simone Wahl, Björn Albrecht, Tamme W. Goecke, Matthias W. Beckmann, Johannes Kornhuber, Peter A. Fasching, Gunther H. Moll, Anna Eichler
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract In order to better understand the underpinnings of attention-deficit/hyperactivity disorder (ADHD), we targeted the relationship of attentional, cognitive control and motivational processes with DNA methylation patterns of 60 candidate genes
Externí odkaz:
https://doaj.org/article/ab2a474178f541bc8cdba5ad566436e0
Autor:
Stefan Coassin, Natascha Hermann-Kleiter, Margot Haun, Simone Wahl, Rory Wilson, Bernhard Paulweber, Sonja Kunze, Thomas Meitinger, Konstantin Strauch, Annette Peters, Melanie Waldenberger, Florian Kronenberg, Claudia Lamina
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0232073 (2020)
Lipoprotein(a) [Lp(a)] is a major cardiovascular risk factor, which is largely genetically determined by one major gene locus, the LPA gene. Many aspects of the transcriptional regulation of LPA are poorly understood and the role of epigenetics has n
Externí odkaz:
https://doaj.org/article/5b25dfac8a494043a3c605edf753ae86