Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Simone, Tambaro"'
Autor:
Simone Tambaro, Sumonto Mitra, Ruchi Gera, Bengt Linderoth, Lars U. Wahlberg, Taher Darreh-Shori, Homira Behbahani, Per Nilsson, Maria Eriksdotter
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background Alzheimer’s disease (AD) is an age-related disease characterized by altered cognition, neuroinflammation, and neurodegeneration against which there is presently no effective cure. Brain-derived neurotrophic factor (BDNF) is a ke
Externí odkaz:
https://doaj.org/article/2406ff59cd24486a931b518362b4d72b
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S447- (2023)
Externí odkaz:
https://doaj.org/article/9d7776fb9efa4033baf770f53114fe82
Autor:
Dina Medina-Vera, Hongjing Zhao, Erika Bereczki, Cristina Rosell-Valle, Makoto Shimozawa, Gefei Chen, Fernando Rodríguez de Fonseca, Per Nilsson, Simone Tambaro
Publikováno v:
Biology, Vol 12, Iss 6, p 805 (2023)
Background: The endocannabinoid system (ECS) and associated lipid transmitter-based signaling systems play an important role in modulating brain neuroinflammation. ECS is affected in neurodegenerative disorders, such as Alzheimer’s disease (AD). He
Externí odkaz:
https://doaj.org/article/97e68dfdb67d4382b3c85ca13d2c9f52
Autor:
Richeng Jiang, Makoto Shimozawa, Johanna Mayer, Simone Tambaro, Rakesh Kumar, Axel Abelein, Bengt Winblad, Nenad Bogdanovic, Per Nilsson
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-β peptide (Aβ) amyloidosis. Amyloid precursor protein (APP) knock-in mice exhibit robust Aβ pathology, providing possibilities to determine its effect o
Externí odkaz:
https://doaj.org/article/5bdec84212d44e5484c5d22672a15608
Autor:
Alvaro Morcuende, María Salud García-Gutiérrez, Simone Tambaro, Elena Nieto, Jorge Manzanares, Teresa Femenia
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Emotional behavior, memory, and learning have been associated with alterations in the immune system in neuropsychiatric and neurodegenerative diseases. In recent years, several studies pointed out the involvement of the cannabinoid receptor 2 (CB2r)
Externí odkaz:
https://doaj.org/article/bf274198561c41f58613cbd158d35743
Autor:
Shaffi Manchanda, Lorena Galan-Acosta, Axel Abelein, Simone Tambaro, Gefei Chen, Per Nilsson, Jan Johansson
Publikováno v:
Molecular Therapy. 31:487-502
Attempts to treat Alzheimer's disease with immunotherapy against the β-amyloid (Aβ) peptide or with enzyme inhibitors to reduce Aβ production have not yet resulted in effective treatment, suggesting that alternative strategies may be useful. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66409921fa2e4b5b0fce1b3ae436180
https://doi.org/10.1016/j.ymthe.2022.08.010
https://doi.org/10.1016/j.ymthe.2022.08.010
Autor:
Gefei Chen, Axel Abelein, Harriet E. Nilsson, Axel Leppert, Yuniesky Andrade-Talavera, Simone Tambaro, Lovisa Hemmingsson, Firoz Roshan, Michael Landreh, Henrik Biverstål, Philip J. B. Koeck, Jenny Presto, Hans Hebert, André Fisahn, Jan Johansson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The BRICHOS domain is a chaperone that can act against amyloid-β peptide fibril formation and non-fibrillar protein aggregation. Here the authors use a multidisciplinary approach and show that the Bri2 BRICHOS domain has qualitatively different chap
Externí odkaz:
https://doaj.org/article/54f4eca3feec44a6b3d1e292c044e1a5
Publikováno v:
Biology, Vol 10, Iss 6, p 542 (2021)
Alzheimer’s disease (AD) is a detrimental brain disorder characterized by a gradual cognitive decline and neuronal deterioration. To date, the treatments available are effective only in the early stage of the disease. The AD etiology has not been c
Externí odkaz:
https://doaj.org/article/133bd78883484920a453386183302198
Autor:
Jiesi Wang, Bai Lu, Wei Zhang, Xi Chen, Weiwen Wang, Bengt Winblad, Johanna Mayer, Ailing Yang, Simone Tambaro, Hua Han, Liu J, Zhengyi Yang, Man Li, Tianzi Jiang, Keliang Pang, Per Nilsson, Wei Guo, Richeng Jiang, Hang Liu, B. Zhang, Linlin Li, Makoto Shimozawa
Publikováno v:
Cell Research
A major obstacle in Alzheimer’s disease (AD) research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy. Transgenic mice overexpressing amyloid precursor protein (App) gene manifest non-phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd61fb13d494841d87a2107cf096d1d
https://doi.org/10.1038/s41422-021-00582-x
https://doi.org/10.1038/s41422-021-00582-x
Autor:
Dina Medina-Vera, Daniela Enache, Simone Tambaro, Ethar Abuhashish, Cristina Rosell-Valle, Bengt Winblad, Fernando Rodríguez de Fonseca, Erika Bereczki, Per Nilsson
Publikováno v:
Brain Communications. 5
Synaptic dysfunction is an early event in Alzheimer’s disease. Post-mortem studies suggest that alterations in synaptic proteins are associated with cognitive decline in Alzheimer’s disease. We measured the concentration of three synaptic protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1dcd954635be575b66392e288fc31eb
https://doi.org/10.1093/braincomms/fcad001
https://doi.org/10.1093/braincomms/fcad001