Výsledky vyhledávání - "Simone, Staffer"

Myeloid-specific fatty acid transport protein 4 deficiency induces a sex-dimorphic susceptibility for nonalcoholic steatohepatitis in mice fed a high-fat, high-cholesterol diet

Autor: Deniz Göcebe, Chutima Jansakun, Yuling Zhang, Simone Staffer, Sabine Tuma-Kellner, Sandro Altamura, Martina U. Muckenthaler, Uta Merle, Thomas Herrmann, Walee Chamulitrat

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 324:G389-G403

FATP4 deficiency in BMDMs and Kupffer cells led to increased proinflammatory response. Fatp4M−/− mice displayed thrombocytopenia, splenomegaly, and elevated liver enzymes. In response to HFHC feeding, male mutants were prone to hepatic steatosis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1795925a56ef4af01ba06d5465f05368
https://doi.org/10.1152/ajpgi.00181.2022

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Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH

Autor: Chutima, Jansakun, Warangkana, Chunglok, Sandro, Altamura, Martina, Muckenthaler, Simone, Staffer, Sabine, Tuma-Kellner, Uta, Merle, Walee, Chamulitrat

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1869:166590

Polymorphisms of phospholipase A2VIA (iPLA2β or PLA2G6) are associated with body weights and blood C-reactive protein. The role of iPLA2β/PLA2G6 in non-alcoholic steatohepatitis (NASH) is still elusive because female iPla2β-null mice showed attenu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f17cae7c8494ec450f5be772225d59d
https://doi.org/10.1016/j.bbadis.2022.166590

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Constitutive oxidants from hepatocytes of male iPLA2β-null mice increases the externalization of phosphatidylethanolamine on plasma membrane

Autor: Hongying Gan-Schreier, Weihong Xu, Walee Chamulitrat, Gerhard Liebisch, Heng Yeng Wong, Sabine Tuma-Kellner, Uta Merle, Simone Staffer, Monika Langlotz

Publikováno v: Free radical research. 55(6)

We have found that group VIA calcium-independent phospholipase A2 (iPLA2β) has specificity for hydrolysis of phosphatidylethanolamine (PE) in mouse livers. Phospholipids (PLs) are transported to plasma membrane and some PLs including PE are external

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea523e35d6206b145c372e8eccf25e51
https://pubmed.ncbi.nlm.nih.gov/34696671

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Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling

Autor: Sabine Tuma-Kellner, Xingya Zhu, Hongying Gan-Schreier, Ann-Christin Otto, Gerhard Liebisch, Walee Chamulitrat, Simone Staffer, Alexandra Ganzha

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1864:662-676

A defect of hepatic remodeling of phospholipids (PL) is seen in non-alcoholic fatty liver disease and steatohepatitis (NASH) indicating pivotal role of PL metabolism in this disease. The deletion of group VIA calcium-independent phospholipase A2 (iPl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c5e2de0df652e4ac7a3979f44347a6
https://doi.org/10.1016/j.bbalip.2019.01.012

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FATP4 inactivation in cultured macrophages attenuates M1- and ER stress-induced cytokine release via a metabolic shift towards triacylglycerides

Autor: Simone Staffer, Yuling Zhang, Hongying Gan-Schreier, Walee Chamulitrat, Sabine Tuma-Kellner, Ning Wu, Jessica Seeßle, Uta Merle, Feng Xu

Publikováno v: The Biochemical journal. 478(10)

Fatty acid transport protein 4 (FATP4) belongs to a family of acyl-CoA synthetases which activate long-chain fatty acids into acyl-CoAs subsequently used in specific metabolic pathways. Patients with FATP4 mutations and Fatp4-null mice show thick des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7bc4bedd7584f07661fc03f6a1542a
https://pubmed.ncbi.nlm.nih.gov/33900381

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