Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts.

Autor: Marion David, Estelle Wannecq, Françoise Descotes, Silvia Jansen, Blandine Deux, Johnny Ribeiro, Claire-Marie Serre, Sandra Grès, Nathalie Bendriss-Vermare, Mathieu Bollen, Simone Saez, Junken Aoki, Jean-Sébastien Saulnier-Blache, Philippe Clézardin, Olivier Peyruchaud

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9741 (2010)

Bone metastases are highly frequent complications of breast cancers. Current bone metastasis treatments using powerful anti-resorptive agents are only palliative indicating that factors independent of bone resorption control bone metastasis progressi

Externí odkaz: https://doaj.org/article/7845bd0a186844a298c4435a219c66b9

Endometrial Cancer following Breast Cancer

Autor: Emmanuelle Amoros, Annie J. Sasco, Simone Saez, Gilles Chaplain

Publikováno v: Epidemiology. 7:9-13

Tamoxifen, a synthetic antiestrogen, has been shown to be effective in reducing mortality from breast cancer and the occurrence of contralateral breast cancer. Tamoxifen is now being studied as a preventive of breast cancer among healthy women consid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a8c852c693e7c56a912f4f5fdc1e9d
https://doi.org/10.1097/00001648-199601000-00003

Analysis of epidermal growth factor receptor mRNA expression by polymerase chain reaction assay in 94 human breast adenocarcinoma tumors

Autor: Rostan Mc, Simone Saez, Artagaveytia N, Bobin Jy, Garin E, Nicole Falette

Publikováno v: Breast Cancer Research and Treatment. 30:275-282

It is well known that breast cancer cells can synthesize and secrete various growth factors that are able to stimulate tumor growth through autocrine and/or paracrine mechanisms. EGF is one of these growth factors involved in normal breast epithelial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ddcce0be8b49f5f9a7da3165275b01
https://doi.org/10.1007/bf00665968

High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer

Autor: Fabrice Tolle, S. Seguin, Annie J. Sasco, J. J. Datchary, Michaël Boyer-Guittaut, Françoise Descotes, Michèle Jouvenot, Alexandre Berthier, Annick Fraichard, Régis Delage-Mourroux, Simone Saez, G. De Laroche, Claire Rodriguez-Lafrasse, J. Y. Bobin

Publikováno v: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2010, 102 (6), pp.1024-31. 〈10.1038/sj.bjc.6605568〉
British Journal of Cancer, Cancer Research UK, 2010, 102 (6), pp.1024-31. ⟨10.1038/sj.bjc.6605568⟩

International audience; BACKGROUND: This study evaluates the relation of the early oestrogen-regulated gene gabarapl1 to cellular growth and its prognostic significance in breast adenocarcinoma. METHODS: First, the relation between GABARAPL1 expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045e801028aba40cf641e617ea14632e
https://hal.archives-ouvertes.fr/hal-00468457

Plasminogen Activator Inhibitor Type 1 is the Most Significant of the Usual Tissue Prognostic Factors in Node-Negative Breast Ductal Adenocarcinoma Independent of Urokinase-Type Plasminogen Activator

Autor: Benjamin Riche, Jean G. Andre, Simone Saez, Jean Yves Bobin, Pascal Roy, Guy De Laroche, Françoise Descotes, Jean Datchary

Publikováno v: Clinical Breast Cancer
Clinical Breast Cancer, 2008, 8(2), pp.168-177
Clinical Breast Cancer, Elsevier, 2008, 8(2), pp.168-177

Purpose The aim of the present investigation was to evaluate the prognostic significance of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) tissue contents in primary breast adenocarcinoma. Patients and Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d7c04ae7a3600c7b36674b0a0146ad
https://hal.science/hal-00428276