Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Simone, Nicolardi"'
Autor:
Pilar Garcia-Vello, Hanne L. P. Tytgat, Janneke Elzinga, Matthias Van Hul, Hubert Plovier, Marta Tiemblo-Martin, Patrice D. Cani, Simone Nicolardi, Marco Fragai, Cristina De Castro, Flaviana Di Lorenzo, Alba Silipo, Antonio Molinaro, Willem M. de Vos
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The cell-envelope of Gram-negative bacteria contains endotoxic lipopolysaccharides (LPS) that are recognized by the innate immune system via Toll-Like Receptors (TLRs). The intestinal mucosal symbiont Akkermansia muciniphila is known to conf
Externí odkaz:
https://doaj.org/article/f6dae89e0f5e4f84b676e2c79896f6ea
Autor:
Isabella Senini, Sara Tengattini, Francesca Rinaldi, Gabriella Massolini, Christoph Gstöttner, Dietmar Reusch, Marcello Donini, Carla Marusic, Peter A. van Veelen, Elena Domínguez-Vega, Manfred Wuhrer, Caterina Temporini, Simone Nicolardi
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Monoclonal antibody (mAb) glycoengineering has the potential to improve the efficacy of biopharmaceuticals by fine-tuning specific biological properties. Glycosylation analysis is key to monitoring the glycoengineering process. Various mass
Externí odkaz:
https://doaj.org/article/1b14d36527f6452a9d61a7e221f66757
Autor:
Tamas Pongracz, Maaike Biewenga, Anna Eva Charlotte Stoelinga, Marco René Bladergroen, Simone Nicolardi, Leendert Adrianus Trouw, Manfred Wuhrer, Noortje de Haan, Bart van Hoek
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Changes in plasma protein glycosylation are known to functionally affect proteins and to associate with liver diseases, including cirrhosis and hepatocellular carcinoma. Autoimmune hepatitis (AIH) is a liver disease characterized
Externí odkaz:
https://doaj.org/article/61e5e7969808451f972e37479229dac5
Autor:
Marco R. Bladergroen, Tamas Pongracz, Wenjun Wang, Simone Nicolardi, Sesmu M. Arbous, Anna Roukens, Manfred Wuhrer
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110374- (2024)
Summary: Total plasma protein N-glycosylation (TPNG) changes are a hallmark of many diseases. Here, we analyzed the TPNG of 169 COVID-19 patients and 12 healthy controls, using mass spectrometry, resulting in the relative quantification of 85 N-glyca
Externí odkaz:
https://doaj.org/article/361a6771232c499a9447afbc045d63f3
Autor:
Gabriane Nascimento Porcino, Marco René Bladergroen, Viktoria Dotz, Simone Nicolardi, Elham Memarian, Luiz Gustavo Gardinassi, Carlos Henrique Nery Costa, Roque Pacheco de Almeida, Isabel Kinney Ferreira de Miranda Santos, Manfred Wuhrer
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107021- (2023)
Summary: Visceral leishmaniasis (VL) is a clinical form of leishmaniasis with high mortality rates when not treated. Diagnosis suffers from invasive techniques and sub-optimal sensitivities. The current (affordable) treatment with pentavalent antimon
Externí odkaz:
https://doaj.org/article/fa0730ec92bf449b98f0676740c35f8a
Autor:
Gerda C. M. Vreeker, Randa G. Hanna‐Sawires, Yassene Mohammed, Marco R. Bladergroen, Simone Nicolardi, Viktoria Dotz, Jan Nouta, Bert A. Bonsing, Wilma E. Mesker, Yuri E. M. van derBurgt, Manfred Wuhrer, Rob A. E. M. Tollenaar
Publikováno v:
Cancer Medicine, Vol 9, Iss 22, Pp 8519-8529 (2020)
Abstract Background &Aims Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer type with loco‐regional spread that makes the tumor surgically unresectable. Novel diagnostic tools are needed to improve detection of PDAC and increase patie
Externí odkaz:
https://doaj.org/article/1acb182db2b74c88aa8104a34bcf47bd
Autor:
Qian Zhu, Zhengnan Shen, Fabrizio Chiodo, Simone Nicolardi, Antonio Molinaro, Alba Silipo, Biao Yu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Glycans are abundant biomolecules that mediate essential biological processes, but their chemical synthesis is challenging. Here, the authors report the synthesis of glycans up to a 128-mer, which represents the O-antigen of Bacteroides vulgatus lipo
Externí odkaz:
https://doaj.org/article/86bc33511a5442518db1317c3d762cbc
Autor:
Steffen Lippold, Simone Nicolardi, Elena Domínguez-Vega, Anna-Katharina Heidenreich, Gestur Vidarsson, Dietmar Reusch, Markus Haberger, Manfred Wuhrer, David Falck
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1191-1196 (2019)
Determination of the impact of individual antibody glycoforms on FcɣRIIIa affinity, and consequently antibody-dependent cell-mediated cytotoxicity (ADCC) previously required high purity glycoengineering. We hyphenated FcɣRIIIa affinity chromatograp
Externí odkaz:
https://doaj.org/article/29cf8fc232b146ef88ded0217ad4cb13
Autor:
Oksana Tyshchuk, Christoph Gstöttner, Dennis Funk, Simone Nicolardi, Stefan Frost, Stefan Klostermann, Tim Becker, Elena Jolkver, Felix Schumacher, Claudia Ferrara Koller, Hans Rainer Völger, Manfred Wuhrer, Patrick Bulau, Michael Mølhøj
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1219-1232 (2019)
Biotherapeutics may contain a multitude of different post-translational modifications (PTMs) that need to be assessed and possibly monitored and controlled to ensure reproducible product quality. During early development of biotherapeutics, unexpecte
Externí odkaz:
https://doaj.org/article/7a56bb8a59684d8daaabf729937341e7
Autor:
Daniel Demus, Annemieke Naber, Viktoria Dotz, Bas C. Jansen, Marco R. Bladergroen, Jan Nouta, Eric J. G. Sijbrands, Mandy Van Hoek, Simone Nicolardi, Manfred Wuhrer
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Apolipoprotein-CIII (apo-CIII) is a glycoprotein involved in lipid metabolism and its levels are associated with cardiovascular disease risk. Apo-CIII sialylation is associated with improved plasma triglyceride levels and its glycosylation may have a
Externí odkaz:
https://doaj.org/article/6e55c7ff43b645b0b1564eac342db323