Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Simone, Mazzaferro"'
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12124 (2022)
We describe genetic and molecular-level functional alterations in the α4β2 neuronal nicotinic acetylcholine receptor (nAChR) from a patient with sleep-related hyperkinetic epilepsy and a family history of epilepsy. Genetic sequencing revealed a het
Externí odkaz:
https://doaj.org/article/9e0fc294328b48ffaa4ae023fad5f56c
Autor:
Sara K.M. Jörgensen, Alena Karnošová, Simone Mazzaferro, Oliver Rowley, Hsiao-Jou Cortina Chen, Sarah J. Robbins, Sarah Christofides, Florian Merkle, Lenka Maletínská, David Petrik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce2f44a910754145e59ad469e59bc5c9
https://doi.org/10.15252/rc.2023119504
https://doi.org/10.15252/rc.2023119504
Autor:
Sara K. M. Jörgensen, Alena Karnošová, Simone Mazzaferro, Oliver Rowley, Hsiao-Jou Cortina Chen, Sarah J. Robbins, Sarah Christofides, Florian T. Merkle, Lenka Maletínská, David Petrik
Hypothalamic Adult Neurogenesis (hAN) has been implicated in regulating energy homeostasis. Adult-generated neurons and adult Neural Stem Cells (aNSCs) in the hypothalamus control food intake and body weight. Conversely, Diet Induced Obesity (DIO) by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e18711e1703ec63ed9545667c4718bcf
https://doi.org/10.1101/2023.02.28.528936
https://doi.org/10.1101/2023.02.28.528936
Publikováno v:
Cell Mol Life Sci
Nicotinic acetylcholine receptors (nAChRs) belong to the superfamily of pentameric ligand-gated ion channels, and in neuronal tissues, are assembled from various types of α- and β-subunits. Furthermore, the subunits α4 and β2 assemble in two pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de289c5df910f35a24f26e6cc286c046
https://doi.org/10.1007/s00018-020-03592-x
https://doi.org/10.1007/s00018-020-03592-x
Publikováno v:
British journal of pharmacologyREFERENCES. 179(7)
BACKGROUND AND PURPOSE α4β2 nicotinic acetylcholine receptors (nAChRs) comprise the most abundant class of nAChRs in the nervous system. They assemble in two stoichiometric forms, each exhibiting distinct functional and pharmacological signatures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c699624185bf95287af23c8f35a0fd4a
https://pubmed.ncbi.nlm.nih.gov/34768309
https://pubmed.ncbi.nlm.nih.gov/34768309
Publikováno v:
British Journal of Pharmacology. 175:1822-1837
Background and purpose The fifth subunit in the (α4β2)2 α4 nicotinic ACh receptor (nAChR) plays a determining role in the pharmacology of this nAChR type. Here, we have examined the role of the fifth subunit in the ACh responses of the (α4β2)2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9537f4cd18dfc9d3f6f09e5ce4f0c660
https://doi.org/10.1111/bph.13905
https://doi.org/10.1111/bph.13905
Publikováno v:
Journal of Biological Chemistry. 292:2729-2740
Acetylcholine receptors comprising α4 and β2 subunits are the most abundant class of nicotinic acetylcholine receptor in the brain. They contribute to cognition, reward, mood, and nociception and are implicated in a range of neurological disorders.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dac20dfc75b9b945677d0a63b570d129
https://doi.org/10.1074/jbc.m116.764183
https://doi.org/10.1074/jbc.m116.764183
Publikováno v:
Neuropharmacology
The ten types of nicotinic acetylcholine receptor α-subunits show substantial sequence homology, yet some types confer high affinity for α-bungarotoxin, whereas others confer negligible affinity. Combining sequence alignments with structural data r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50d47d7149fc0265bb5785654573c06
https://europepmc.org/articles/PMC6842095/
https://europepmc.org/articles/PMC6842095/
Publikováno v:
Cell Mol Life Sci
Neuronal nicotinic receptors containing α4 and β2 subunits assemble in two pentameric stoichiometries, (α4)(3)(β2)(2) and (α4)(2)(β2)(3), each with distinct pharmacological signatures; (α4)(3)(β2)(2) receptors are strongly potentiated by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6359f02ffdb64fc7445d6e7c338b1419
https://europepmc.org/articles/PMC8022356/
https://europepmc.org/articles/PMC8022356/
Autor:
Manuel Faundez, Isabel Bermudez, Teresa Minguez, Philip C. Biggin, Patricio Iturriaga-Vásquez, Constanza Alcaino, Simone Mazzaferro, Maria Musgaard
Publikováno v:
Journal Of Biological Chemistry
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist binding to channel gating. Using α4β2 nicotinic acetylcholine receptors and the α4β2-selective positive modulators 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4820c8698c2d4e807a23cdcdc78b7737