Výsledky vyhledávání - "Simone, Josephine"

Akademický článek

A career break questionnaire for employees and human resource practitioners

Autor: Simone, Josephine, Kannan, Selvi

Publikováno v: Strategic HR Review, 2023, Vol. 22, Issue 1, pp. 32-33.

Externí odkaz: http://www.emeraldinsight.com/doi/10.1108/SHR-02-2023-197

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Older Age Autism Research: A Rapidly Growing Field, but Still a Long Way to Go

Autor: David Mason, Gavin Robert Stewart, Simone Josephine Capp, Francesca Happé

Publikováno v: Autism Adulthood

There is a paucity of research involving older autistic people, as highlighted in a number of systematic reviews. However, it is less clear whether this is changing, and what the trends might be in research on autism in later life.We conducted a broa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be7be05ad4579cb5cc097b9ef9aa795
https://pubmed.ncbi.nlm.nih.gov/36605971

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Synthesis, Structure−Activity Relationship, and Receptor Pharmacology of a New Series of Quinoline Derivatives Acting as Selective, Noncompetitive mGlu1 Antagonists

Autor: Dominique Jean-Pierre Mabire, Alain Philippe Poncelet, Anne Simone Josephine Lesage, Ludy van Beijsterveldt, François Paul Bischoff, Ria Wouters, Christophe Adelinet, Yvan Rene Simonnet, Sophie Coupa, Marc Venet

Publikováno v: Journal of Medicinal Chemistry. 48:2134-2153

We describe the discovery and the structure-activity relationship of a new series of quinoline derivatives acting as selective and highly potent noncompetitive mGlu1 antagonists. We first identified cis-10 as a fairly potent mGlu1 antagonist (IC(50)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7727d62ed8ca5b6fa5eb08621ef93b
https://doi.org/10.1021/jm049499o

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Effects of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression test

Autor: Nancy Aerts, Anne Simone Josephine Lesage, Ana M.M. Oliveira, Thomas Steckler, Hansfried Van Craenendonck, Anton Megens, Jos Prickaerts, Hilde Lavreysen

Publikováno v: Psychopharmacology, 179, 198-206. Springer

Group I metabotropic glutamate receptor antagonists, which block both the mGlu1 and mGlu5 receptors, have been shown to have anxiolytic effects in the lick suppression test in rats. The anxiolytic potential of the selective mGlu1 antagonist 3,4-dihyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742f19bb1c89351ff798841da2ac57c6
https://doi.org/10.1007/s00213-004-2056-7

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MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum

Autor: Xavier Langlois, Jean-Marc Taymans, Josée E. Leysen, Anne Simone Josephine Lesage, Catarina Cruz

Publikováno v: Neuroreport, 16(2), 159-162. Lippincott Williams and Wilkins Ltd.
Taymans, J M, Cruz, C, Lesage, A S, Leysen, J E M F & Langlois, X 2005, ' MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum ', Neuroreport, vol. 16, no. 2, pp. 159-162 . https://doi.org/10.1097/00001756-200502080-00018

The present report examines the eiects of acute NMDA antagonism on Regulator of G Protein Signaling 2 (RGS2) expression and adenylyl cyclase sensitivity in the rat striatum. MK- 801and phencyclidine rapidly down-regulate RGS2 mRNA. The down-regulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88c7e6cccfa795f055f9a7eaf0863e9
https://doi.org/10.1097/00001756-200502080-00018

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JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist

Autor: Lieve Dillen, Saskia Blokland, Hilde Lavreysen, Sandrina Nóbrega Pereira, François Paul Bischoff, Anne Simone Josephine Lesage, Ria Wouters, Xavier Langlois, Marijke Somers

Publikováno v: Neuropharmacology. 47:961-972

We examined the pharmacological profile of (3,4-dihydro-2H-pyrano[2,3]b quinolin-7-yl) (cis-4-methoxycyclohexyl) methanone (JNJ16259685). At recombinant rat and human metabotropic glutamate (mGlu) 1a receptors, JNJ16259685 non-competitively inhibited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d6aeb782e5611d3db8a5411c4d09de
https://doi.org/10.1016/j.neuropharm.2004.08.007

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Internalization of Human 5-HT4a and 5-HT4b Receptors is Splice Variant Dependent

Autor: Mirek R. Jurzak, Paul Van Gompel, Anne Simone Josephine Lesage, Katty Josson, Josée E. Leysen, Armelle Pindon, Geert Van Hecke

Publikováno v: Bioscience Reports. 24:215-223

The family of 5-HT4 receptors comprises 16 putative splice variants. We have previously shown that there are differences in signal transduction of the h5-HT4a and h5-HT4b receptors. In the present study, the internalization of these two splice varian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6977989380ca83496ab646f545cfb5
https://doi.org/10.1007/s10540-005-2582-5

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[3H]R214127: A Novel High-Affinity Radioligand for the mGlu1 Receptor Reveals a Common Binding Site Shared by Multiple Allosteric Antagonists

Autor: Anne Simone Josephine Lesage, Josée E. Leysen, Xavier Langlois, Hilde Lavreysen, Cor Janssen, François Paul Bischoff

Publikováno v: Molecular Pharmacology. 63:1082-1093

R214127 was shown to be a potent and noncompetitive metabotropic glutamate 1 (mGlu1) receptor-selective antagonist. The kinetics and pharmacology of [(3)H]1-(3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-2-phenyl-1-ethanone (R214127) binding to rat mGlu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b821290742ab0956aa29e9730f9307b
https://doi.org/10.1124/mol.63.5.1082

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Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii

Autor: Luc Van Puyvelde, Simon G. Mathenge, Miroslav Cik, Francis P. Mudida, Josée E. Leysen, Wouters Walter Boudewijn Leopo, Jacky Van Dun, Ilse Van der Lindin, Anne Simone Josephine Lesage, Giovanni Appendino, Norbert De Kimpe, Weidong He

Publikováno v: Bioorganic & Medicinal Chemistry. 10:3245-3255

Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa7db602da998f88d0a94f8fe21ac49
https://doi.org/10.1016/s0968-0896(02)00163-3

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Mammalian GFRα-4, a Divergent Member of the GFRα Family of Coreceptors for Glial Cell Line-derived Neurotrophic Factor Family Ligands, Is a Receptor for the Neurotrophic Factor Persephin

Autor: Robert Gordon, Paul Van Gompel, Ilse Van der Linden, Anne Simone Josephine Lesage, Carlos F. Ibáñez, Rizaldy P. Scott, Peter Verhasselt, Christopher A. Nosrat, Hoefnagel Evert Wilhelmus, Stefan Masure, Miroslav Cik

Publikováno v: Journal of Biological Chemistry. 275:39427-39434

Four members of the glial cell line-derived neurotrophic factor family have been identified (GDNF, neurturin, persephin, and enovin/artemin). They bind to a specific membrane-anchored GDNF family receptor as follows: GFRalpha-1 for GDNF, GFRalpha-2 f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96dd7a9467f0131fc47b75c77a8422c4
https://doi.org/10.1074/jbc.m003867200

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