Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Simone, Brioschi"'
Publikováno v:
Vaccines, Vol 10, Iss 6, p 943 (2022)
Tumor-associated macrophages (TAMs) represent a key component of the tumor microenvironment and are generally associated with immunosuppression and poor prognosis. TREM2 is a transmembrane receptor of the immunoglobulin superfamily expressed in myelo
Externí odkaz:
https://doaj.org/article/e7764fed5fd34ab7b27addfd8ed5f58a
Autor:
Simone Brioschi, Paolo d’Errico, Lukas S. Amann, Hana Janova, Sonja M. Wojcik, Melanie Meyer-Luehmann, Lawrence Rajendran, Peter Wieghofer, Rosa C. Paolicelli, Knut Biber
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
A growing body of evidence indicates that microglia actively remove synapses in vivo, thereby playing a key role in synaptic refinement and modulation of brain connectivity. This phenomenon was mainly investigated in immunofluorescence staining and c
Externí odkaz:
https://doaj.org/article/4212dc9e7c4743df81cd46c466e44482
Autor:
Simone Brioschi, Julia A. Belk, Vincent Peng, Martina Molgora, Patrick Fernandes Rodrigues, Khai M. Nguyen, Shoutang Wang, Siling Du, Wei-Le Wang, Gary E. Grajales-Reyes, Jennifer M. Ponce, Carla M. Yuede, Qingyun Li, John M. Baer, David G. DeNardo, Susan Gilfillan, Marina Cella, Ansuman T. Satpathy, Marco Colonna
Publikováno v:
Immunity. 56:1027-1045.e8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7cb105939c763b25d6363d01849d88e
https://doi.org/10.1016/j.immuni.2023.01.028
https://doi.org/10.1016/j.immuni.2023.01.028
Publikováno v:
The Journal of Immunology. 204:294-305
Microglia are parenchymal macrophages of the CNS; as professional phagocytes they are important for maintenance of the brain’s physiology. These cells are generated through primitive hematopoiesis in the yolk sac and migrate into the brain rudiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fba1e9dac3543d6982be9be403968a50
https://doi.org/10.4049/jimmunol.1900821
https://doi.org/10.4049/jimmunol.1900821
Autor:
Pierre Garcia, Wiebke Jürgens‐Wemheuer, Oihane Uriarte Huarte, Alessandro Michelucci, Annette Masuch, Simone Brioschi, Andreas Weihofen, Eric Koncina, Djalil Coowar, Tony Heurtaux, Enrico Glaab, Rudi Balling, Carole Sousa, Tony Kaoma, Nathalie Nicot, Tatjana Pfander, Walter Schulz‐Schaeffer, Ahmad Allouche, Nicolas Fischer, Knut Biber, Felix Kleine‐Borgmann, Michel Mittelbronn, Marek Ostaszewski, Kristopher J. Schmit, Manuel Buttini
Background: Akey process of neurodegeneration in Parkinson’s disease (PD) is the transneuronal spreading of a-synuclein. Alpha-synuclein is a presynaptic protein that is implicated in the pathogenesis of PD and other synucleinopathies, where it for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88537d06b41a2c229001a60d01e5d9bb
http://orbilu.uni.lu/handle/10993/50437
http://orbilu.uni.lu/handle/10993/50437
Autor:
Shoutang Wang, Raki Sudan, Vincent Peng, Yingyue Zhou, Siling Du, Carla M. Yuede, Tingting Lei, Jinchao Hou, Zhangying Cai, Marina Cella, Khai Nguyen, Pietro L. Poliani, Wandy L. Beatty, Yun Chen, Siyan Cao, Kent Lin, Cecilia Rodrigues, Ali H. Ellebedy, Susan Gilfillan, Gordon D. Brown, David M. Holtzman, Simone Brioschi, Marco Colonna
Publikováno v:
Cell. 185(22)
Genetic studies have highlighted microglia as pivotal in orchestrating Alzheimer's disease (AD). Microglia that adhere to Aβ plaques acquire a transcriptional signature, "disease-associated microglia" (DAM), which largely emanates from the TREM2-DAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2518bade01cf27e82ea856c7902f272d
https://pubmed.ncbi.nlm.nih.gov/36306735
https://pubmed.ncbi.nlm.nih.gov/36306735
Publikováno v:
Trends in Neurosciences. 42:440-443
In a recent study, Masuda and colleagues (Nature 2019;566:388–392) used single-cell RNA-sequencing (scRNA-seq) to profile microglia across different anatomical compartments, developmental stages, and types of brain pathology in mice. Moreover, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cec2c4bc6bdabc9959390502e33eefa
https://doi.org/10.1016/j.tins.2019.03.010
https://doi.org/10.1016/j.tins.2019.03.010
Autor:
Catrina Fronick, Vincent Peng, Zev J. Greenberg, Meng Wang, Jennifer K. Bando, Wandy L. Beatty, Wei Le Wang, Laura G. Schuettpelz, Gregory F. Wu, Igor Smirnov, Marco Colonna, Virginia Smith Shapiro, Amanda Swain, Natalia Jaeger, Marina Cella, Steven H. Kleinstein, Jonathan Kipnis, James A. J. Fitzpatrick, Denis A. Mogilenko, Susan Gilfillan, Peter O. Bayguinov, Rafael S. Czepielewski, Irina Shchukina, Simone Brioschi, Maxim N. Artyomov
Publikováno v:
Science
Getting around the blood–brain barrier The meninges comprise three membranes that surround and protect the central nervous system (CNS). Recent studies have noted the existence of myeloid cells resident there, but little is known about their ontoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e9a5555c22cd2b567a2b7d193cd613
https://europepmc.org/articles/PMC8448524/
https://europepmc.org/articles/PMC8448524/
Autor:
Dawn Weishuhn, Simone Brioschi, Diana Cha, Marco Colonna, Daniel Yoo, Sara Rao, Samuel A. Hasson, Jodi Bradley, Peng Luan, Ian Foltz, Shilpa Sambashivan, Shoutang Wang, Daniel C. Ellwanger, Menno Van Lookeren Campagne, Susan Gilfillan, Palaniswami Rathanaswami, Ryan Case, Lydia Green, Zhifei Shao
Publikováno v:
Proc Natl Acad Sci U S A
Triggering receptor expressed on myeloid cells 2 (TREM2) sustains microglia response to brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (Aβ). Alzheimer’s disease (AD) risk is associated with the TREM2(R47H) variant, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e7e2a0334e1a0bf5f3ff55b8cfd453
https://doi.org/10.1073/pnas.2017742118
https://doi.org/10.1073/pnas.2017742118
Publikováno v:
Vaccines. 10:943
Tumor-associated macrophages (TAMs) represent a key component of the tumor microenvironment and are generally associated with immunosuppression and poor prognosis. TREM2 is a transmembrane receptor of the immunoglobulin superfamily expressed in myelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22dcaf96d5bd0d1f8becec5ded16e7a0
https://doi.org/10.3390/vaccines10060943
https://doi.org/10.3390/vaccines10060943