Neuroforensomics: metabolites as valuable biomarkers in cerebrospinal fluid of lethal traumatic brain injuries

Autor: Simone Bohnert, Christoph Reinert, Stefanie Trella, Andrea Cattaneo, Ulrich Preiß, Michael Bohnert, Johann Zwirner, Andreas Büttner, Werner Schmitz, Benjamin Ondruschka

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Traumatic brain injury (TBI) is a ubiquitous, common sequela of accidents with an annual prevalence of several million cases worldwide. In forensic pathology, structural proteins of the cellular compartments of the CNS in serum and cerebrosp

Externí odkaz: https://doaj.org/article/7252679f5bfa4c0b971ccabdcbe627a7

SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma?

Autor: Mario Löhr, Wolfgang Härtig, Almut Schulze, Matthias Kroiß, Silviu Sbiera, Constantin Lapa, Bianca Mages, Sabrina Strobel, Jennifer Elisabeth Hundt, Simone Bohnert, Stefan Kircher, Sudha Janaki-Raman, Camelia-Maria Monoranu

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 7, p 3726 (2022)

Targeting molecular alterations as an effective treatment for isocitrate dehydrogenase-wildtype glioblastoma (GBM) patients has not yet been established. Sterol-O-Acyl Transferase 1 (SOAT1), a key enzyme in the conversion of endoplasmic reticulum cho

Externí odkaz: https://doaj.org/article/899856ab4732425a84d356e11efcc418

Screening for Fatal Traumatic Brain Injuries in Cerebrospinal Fluid Using Blood-Validated CK and CK–MB Immunoassays

Autor: Johann Zwirner, Sven Anders, Simone Bohnert, Ralph Burkhardt, Ugo Da Broi, Niels Hammer, Dirk Pohlers, Rexson Tse, Benjamin Ondruschka

Publikováno v: Biomolecules, Vol 11, Iss 7, p 1061 (2021)

A single, specific, sensitive biochemical biomarker that can reliably diagnose a traumatic brain injury (TBI) has not yet been found, but combining different biomarkers would be the most promising approach in clinical and postmortem settings. In addi

Externí odkaz: https://doaj.org/article/29601f2117a6425eafc434639778cd39

Is There Any Evidence of Monocytes Involvement in Alzheimer’s Disease? A Pilot Study on Human Postmortem Brain

Autor: Peter Riederer, Tim Hartmann, Simone Bohnert, Sabrina Strobel, Helmut Heinsen, Camelia-Maria Monoranu, Luitpold Distel

Publikováno v: Journal of Alzheimer's Disease Reports
Monoranu, C M, Hartmann, T, Strobel, S, Heinsen, H, Riederer, P, DIstel, L & Bohnert, S 2021, ' Is There Any Evidence of Monocytes Involvement in Alzheimer's Disease? A Pilot Study on Human Postmortem Brain ', Journal of Alzheimer's Disease Reports, vol. 5, no. 1, pp. 887-897 . https://doi.org/10.3233/ADR-210052

Background: The role of neuroinflammation has become more evident in the pathogenesis of neurodegenerative diseases. Increased expression of microglial markers is widely reported in Alzheimer’s disease (AD), but much less is known about the role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9eb22a2a14bb96d720cc32b4d12e4b
https://doi.org/10.3233/adr-210052

Myelin basic protein and neurofilament H in postmortem cerebrospinal fluid as surrogate markers of fatal traumatic brain injury

Autor: Stefanie Trella, Camelia-Maria Monoranu, Michael Bohnert, Simone Bohnert, Werner Schmitz, Christoph Wirth, Benjamin Ondruschka

Publikováno v: International Journal of Legal Medicine

The aim of this study was to investigate if the biomarkers myelin basic protein (MBP) and neurofilament-H (NF-H) yielded informative value in forensic diagnostics when examining cadaveric cerebrospinal fluid (CSF) biochemically via an enzyme-linked i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2109d5cc09514f0bcd341344d614e554
http://europepmc.org/articles/PMC8205912