Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Simona-Adriana Manea"'
1
Akademický článek
Pharmacological Inhibition of Lysine-Specific Demethylase 1A Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice by a Mechanism Involving Decreased Oxidative Stress and Inflammation; Potential Implications in Human Atherosclerosis
Autor: Simona-Adriana Manea, Mihaela-Loredana Vlad, Alexandra-Gela Lazar, Horia Muresian, Maya Simionescu, Adrian Manea
Publikováno v: Antioxidants, Vol 11, Iss 12, p 2382 (2022)
Dysregulated epigenetic mechanisms promote transcriptomic and phenotypic alterations in cardiovascular diseases. The role of histone methylation-related pathways in atherosclerosis is largely unknown. We hypothesize that lysine-specific demethylase 1
Externí odkaz: https://doaj.org/article/1e1de9347e21402abd50c0a8ada04168
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2
Akademický článek
Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclerosis
Autor: Simona-Adriana Manea, Mihaela-Loredana Vlad, Ioana Madalina Fenyo, Alexandra-Gela Lazar, Monica Raicu, Horia Muresian, Maya Simionescu, Adrian Manea
Publikováno v: Redox Biology, Vol 28, Iss , Pp - (2020)
NADPH oxidase (Nox)-derived reactive oxygen species (ROS) are instrumental in all inflammatory phases of atherosclerosis. Dysregulated histone deacetylase (HDAC)-related epigenetic pathways have been mechanistically linked to alterations in gene expr
Externí odkaz: https://doaj.org/article/f9222191c4894c2ea160952311591c0f
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3
Akademický článek
Epigenetic regulation of vascular NADPH oxidase expression and reactive oxygen species production by histone deacetylase-dependent mechanisms in experimental diabetes
Autor: Simona-Adriana Manea, Mihaela-Loredana Antonescu, Ioana Madalina Fenyo, Monica Raicu, Maya Simionescu, Adrian Manea
Publikováno v: Redox Biology, Vol 16, Iss , Pp 332-343 (2018)
Reactive oxygen species (ROS) generated by up-regulated NADPH oxidase (Nox) contribute to structural-functional alterations of the vascular wall in diabetes. Epigenetic mechanisms, such as histone acetylation, emerged as important regulators of gene
Externí odkaz: https://doaj.org/article/32808910f45d4220b45852d535d665fb
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4
Akademický článek
Activated Histone Acetyltransferase p300/CBP-Related Signalling Pathways Mediate Up-Regulation of NADPH Oxidase, Inflammation, and Fibrosis in Diabetic Kidney
Autor: Alexandra-Gela Lazar, Mihaela-Loredana Vlad, Adrian Manea, Maya Simionescu, Simona-Adriana Manea
Publikováno v: Antioxidants, Vol 10, Iss 9, p 1356 (2021)
Accumulating evidence implicates the histone acetylation-based epigenetic mechanisms in the pathoetiology of diabetes-associated micro-/macrovascular complications. Diabetic kidney disease (DKD) is a progressive chronic inflammatory microvascular dis
Externí odkaz: https://doaj.org/article/32c9854163a94f8cb604c1e5802f6a24
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5
Akademický článek
Regulation of Nox enzymes expression in vascular pathophysiology: Focusing on transcription factors and epigenetic mechanisms
Autor: Simona-Adriana Manea, Alina Constantin, Gina Manda, Shlomo Sasson, Adrian Manea
Publikováno v: Redox Biology, Vol 5, Iss , Pp 358-366 (2015)
NADPH oxidases (Nox) represent a family of hetero-oligomeric enzymes whose exclusive biological function is the generation of reactive oxygen species (ROS). Nox-derived ROS are essential modulators of signal transduction pathways that control key phy
Externí odkaz: https://doaj.org/article/2eaed47412fe4ac497d29d8880218b52
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6
Akademický článek
High glucose-induced increased expression of endothelin-1 in human endothelial cells is mediated by activated CCAAT/enhancer-binding proteins.
Autor: Simona-Adriana Manea, Andra Todirita, Adrian Manea
Publikováno v: PLoS ONE, Vol 8, Iss 12, p e84170 (2013)
High glucose-induced endothelial dysfunction is partially mediated by the down-stream pathophysiological effects triggered by increased expression of endothelin-1 (ET-1). The molecular control mechanisms of ET-1 synthesis are yet to be discovered. Me
Externí odkaz: https://doaj.org/article/9eebd710d9f24ed8b03db33a1d30070a
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7
Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High-Resolution Near-Infrared Fluorescence Imaging Using VCAM-1-Targeted Liposomes Entrapping a Fluorogenic Redox-Sensitive Probe
Autor: Maya Simionescu, Simona-Adriana Manea, Daniela Rebleanu, A.G. Lazar, Adrian Manea, Manuela Calin, Ioana Madalina Fenyo, Mihaela-Loredana Vlad
Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Excessive production of reactive oxygen species (ROS) and the ensuing oxidative stress are instrumental in all phases of atherosclerosis. Despite the major achievements in understanding the regulatory pathways and molecular sources of ROS in the vasc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee43390c914480c3cd9d397baa2d9d6
https://doi.org/10.1155/2021/6685612
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8
Epigenetic regulation of vascular NADPH oxidase expression and reactive oxygen species production by histone deacetylase-dependent mechanisms in experimental diabetes
Autor: Monica Raicu, Maya Simionescu, Mihaela-Loredana Antonescu, Ioana Madalina Fenyo, Simona-Adriana Manea, Adrian Manea
Publikováno v: Redox Biology
Redox Biology, Vol 16, Iss, Pp 332-343 (2018)
Reactive oxygen species (ROS) generated by up-regulated NADPH oxidase (Nox) contribute to structural-functional alterations of the vascular wall in diabetes. Epigenetic mechanisms, such as histone acetylation, emerged as important regulators of gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78bd5bc3b6c199e70a5e710bd225dcc
https://doi.org/10.1016/j.redox.2018.03.011
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9
Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis
Autor: Monica Raicu, Horia Muresian, Mihaela-Loredana Vlad, Adrian Manea, Maya Simionescu, A.G. Lazar, Simona-Adriana Manea
Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity
Histone acetylation plays a major role in epigenetic regulation of gene expression. Monocyte-derived macrophages express functional NADPH oxidase 5 (Nox5) that contributes to oxidative stress in atherogenesis. The mechanisms of Nox5 regulation are no
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ea8e5ca9211fc93e3699730868fd84
https://doaj.org/article/6c2e82603c0d42fab4d3aec621a198be
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10
c-Src tyrosine kinase mediates high glucose-induced endothelin-1 expression
Autor: Simona-Adriana Manea, Adrian Manea, Ioana Madalina Fenyo
Publikováno v: The International Journal of Biochemistry & Cell Biology. 75:123-130
Endothelin-1 (ET-1) plays an important role in the pathophysiology of diabetes-associated cardiovascular disorders. The molecular mechanisms leading to ET-1 upregulation in diabetes are not entirely defined. c-Src tyrosine kinase regulates important
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955b03954c0feddca1ed7f8531701307
https://doi.org/10.1016/j.biocel.2016.04.008
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