Flexible Polyurethane Foams from Bio-Based Polyols: Prepolymer Synthesis and Characterization

Autor: Simona Losio, Angelica Cifarelli, Adriano Vignali, Simona Tomaselli, Fabio Bertini

Publikováno v: Polymers, Vol 15, Iss 22, p 4423 (2023)

Bio-polyols (BPOs), characterized by a hydroxyl number up to around 90 mg KOH/g, narrow polydispersity index and relatively low molecular mass up to 2000 g/mol, were synthetized from partially and completely epoxidized soybean and linseed oils and ca

Externí odkaz: https://doaj.org/article/dd9615c7789743f3934399ff30e5435e

Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms

Autor: Katiuscia Pagano, Simona Tomaselli, Henriette Molinari, Laura Ragona

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, with no cure and preventive therapy. Misfolding and extracellular aggregation of Amyloid-β (Aβ) peptides are recognized as the main cause of AD progression, leading t

Externí odkaz: https://doaj.org/article/878361269cee42229ed8a6d9027e1e4d

Direct and allosteric inhibition of the FGF2/HSPGs/FGFR1 ternary complex formation by an antiangiogenic, thrombospondin-1-mimic small molecule.

Autor: Katiuscia Pagano, Rubben Torella, Chiara Foglieni, Antonella Bugatti, Simona Tomaselli, Lucia Zetta, Marco Presta, Marco Rusnati, Giulia Taraboletti, Giorgio Colombo, Laura Ragona

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36990 (2012)

Fibroblast growth factors (FGFs) are recognized targets for the development of therapies against angiogenesis-driven diseases, including cancer. The formation of a ternary complex with the transmembrane tyrosine kinase receptors (FGFRs), and heparan

Externí odkaz: https://doaj.org/article/061b20b1ac724c3e97bcd6d72331e2bd

Biophysical and in Vivo Studies Identify a New Natural-Based Polyphenol, Counteracting Aβ Oligomerization in Vitro and Aβ Oligomer-Mediated Memory Impairment and Neuroinflammation in an Acute Mouse Model of Alzheimer’s Disease

Autor: Gianluigi Forloni, Pietro La Vitola, Luca Banfi, Giulia Santamaria, Claudia Fracasso, Denise Galante, Claudia Balducci, Jacopo Lucchetti, Chiara Lambruschini, Laura Ragona, Simona Tomaselli, Cristina D'Arrigo, Edoardo Brandi, Katiuscia Pagano, Lisa Moni, Henriette Molinari

Publikováno v: ACS Chemical Neuroscience. 10:4462-4475

In this study natural-based complex polyphenols, obtained through a smart synthetic approach, have been evaluated for their ability to inhibit the formation of Aβ42 oligomers, the most toxic species causing synaptic dysfunction, neuroinflammation, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ea55cd5bf0c5868db078c86e657a73
https://doi.org/10.1021/acschemneuro.9b00241

Acetylcholinesterase-induced fluorescence turn-off of an oligothiophene-grafted quartz surface sensitive to myristoylcholine

Autor: Simona Tomaselli, Laura Ragona, F. Samperi, Katiuscia Pagano, Silvia Destri, Umberto Giovanella, Francesco Galeotti, Giorgio Grisci, Wojciech Mróz, William Porzio

Publikováno v: Journal of Materials Chemistry B 3 (2015): 4892–4903. doi:10.1039/c5tb00679a
info:cnr-pdr/source/autori:Grisci G.; Mroz W.; Giovanella U.; Pagano K.; Porzio W.; Ragona L.; Samperi F.; Tomaselli S.; Galeotti F.; Destri S./titolo:Acetylcholinesterase-induced fluorescence turn-off of an oligothiophene-grafted quartz surface sensitive to myristoylcholine/doi:10.1039%2Fc5tb00679a/rivista:Journal of Materials Chemistry B/anno:2015/pagina_da:4892/pagina_a:4903/intervallo_pagine:4892–4903/volume:3

Conjugated polyelectrolytes (CPEs) have recently emerged as label-free materials for biosensing due to their intrinsic ability to transduce an amplified optical signal in response to interactions with different analytes. Herein, the conformational ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea28b648b0004feb290d81eb3d3588f7
https://pubmed.ncbi.nlm.nih.gov/32262678