Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Simona Tolarova"'
Publikováno v:
The Journal of Physiology. 533:253-261
How the ductus arteriosus (DA) closes at birth remains unclear. Inhibition of O2-sensitive K+ channels may initiate the closure but the sensor mechanism is unknown. We hypothesized that changes in endogenous H2O2 could act as this sensor. Using chemi
Autor:
Simona Tolarova, Evangelos D. Michelakis, Stephen L. Archer, Edward K Weir, Vaclav Hampl, James M.C. Huang, Helen L. Reeve
Publikováno v:
Circulation Research. 78:431-442
Abstract The cellular mechanisms that determine differences in reactivity of arteries of varying size and origin are unknown. We evaluated the hypothesis that there is diversity in the distribution of K + channels between vascular smooth muscle (VSM)
Publikováno v:
Experimental Dermatology. 23:97-98
The fields of dermatology and transplantation biology have recently come together in clinical trials of bone marrow transplantation for severe inherited blistering skin diseases. But the original link between these two disciplines goes back to an ext
Autor:
E. Kenneth Weir, Helen L. Reeve, Stephen L. Archer, David N. Cornfield, Daniel P. Nelson, Simona Tolarova
Publikováno v:
Oxygen Homeostasis and Its Dynamics ISBN: 9784431684787
In the fetus, the lungs are not ventilated and arterial oxygen tension is approximately 22 mmHg. Under these conditions, the ductus arteriosus is open and the pulmonary vasculature is constricted. At birth, the ductus constricts and the pulmonary ves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7d755ea2ddd00898a9fff59686ff485
https://doi.org/10.1007/978-4-431-68476-3_50
https://doi.org/10.1007/978-4-431-68476-3_50
Publikováno v:
Oxygen Homeostasis and Its Dynamics ISBN: 9784431684787
The ductus arteriosus (DA) is a vital fetal structure that acts as a right-to-left shunt to divert blood flow away from the constricted pulmonary circulation in the developing fetus. At birth, the DA constricts as a direct result of the increase in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7202daa8cd9eb1269c64d60467f2fc9e
https://doi.org/10.1007/978-4-431-68476-3_60
https://doi.org/10.1007/978-4-431-68476-3_60
Autor:
David N. Cornfield, Stephen L. Archer, Edward B. Martin, Simona Tolarova, Edward K Weir, Martin Tristani-Firouzi
Publikováno v:
The American journal of physiology. 271(6 Pt 2)
At birth, pulmonary blood flow rapidly increases 8- to 10-fold, and pulmonary arterial pressure falls by 50% within 24 h. The postnatal adaptation of the pulmonary circulation is mediated, in part, by endothelium-derived nitric oxide (EDNO). Recent s
At birth, pulmonary vasodilation occurs as air-breathing life begins. The mechanism of O2-induced pulmonary vasodilation is unknown. We proposed that O2 causes fetal pulmonary vasodilation through activation of a calcium-dependent potassium channel (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fb3c110a0583ab1d99b91c22998890
https://europepmc.org/articles/PMC38880/
https://europepmc.org/articles/PMC38880/
Publikováno v:
Journal of Molecular and Cellular Cardiology. 33:A158
Publikováno v:
Pediatric Research. 39:339-339
Postnatal adaptation of the pulmonary circulation is mediated by endothelium-derived nitric oxide (EDNO). Recent studies have demonstrated that inhaled nitric oxide (NO) causes selective and sustained vasodilation in infants with PPHN. The short half