Zobrazeno 1 - 10
of 441
pro vyhledávání: '"Simona Soverini"'
Autor:
Samantha Bruno, Enrica Borsi, Agnese Patuelli, Lorenza Bandini, Manuela Mancini, Dorian Forte, Jacopo Nanni, Martina Barone, Alessandra Grassi, Gianluca Cristiano, Claudia Venturi, Valentina Robustelli, Giulia Atzeni, Cristina Mosca, Sara De Santis, Cecilia Monaldi, Andrea Poletti, Carolina Terragna, Antonio Curti, Michele Cavo, Simona Soverini, Emanuela Ottaviani
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10002 (2024)
Acute myeloid leukemia (AML) is an aggressive hematologic neoplasia with a complex polyclonal architecture. Among driver lesions, those involving the FLT3 gene represent the most frequent mutations identified at diagnosis. The development of tyrosine
Externí odkaz:
https://doaj.org/article/5b193e17ecea421993b1226fc475a0cc
Autor:
Manuela Mancini, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, Michela Rondoni, Chiara Sartor, Samantha Bruno, Livio Pagano, Marianna Criscuolo, Roberta Zanotti, Massimiliano Bonifacio, Patrizia Tosi, Michel Arock, Peter Valent, Michele Cavo, Simona Soverini
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Background The SETD2 tumor suppressor gene encodes a histone methyltransferase that safeguards transcription fidelity and genomic integrity via trimethylation of histone H3 lysine 36 (H3K36Me3). SETD2 loss of function has been observed in so
Externí odkaz:
https://doaj.org/article/86e4a6a879e64e2e8360ae2fd89410f4
Autor:
Samantha Bruno, Andrea Ghelli Luserna di Rorà, Roberta Napolitano, Simona Soverini, Giovanni Martinelli, Giorgia Simonetti
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Cell division cycle 20 homologue (CDC20) is a well-known regulator of cell cycle, as it controls the correct segregation of chromosomes during mitosis. Many studies have focused on the biological role of CDC20 in cancer development, as alter
Externí odkaz:
https://doaj.org/article/0c69bd628a4a45b0ad8924f3ed144bf6
Autor:
Manuela Mancini, Sara De Santis, Cecilia Monaldi, Fausto Castagnetti, Annalisa Lonetti, Samantha Bruno, Elisa Dan, Barbara Sinigaglia, Gianantonio Rosti, Michele Cavo, Gabriele Gugliotta, Simona Soverini
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
In chronic myeloid leukemia (CML), Aurora kinase A and Polo like kinase 1 (PLK1), two serine-threonine kinases involved in the maintenance of genomic stability by preserving a functional G2/M checkpoint, have been implicated in BCR::ABL1-independent
Externí odkaz:
https://doaj.org/article/aae0fc7804b24c869673a00cf1c73ea8
Autor:
Miriam Iezza, Sofia Cortesi, Emanuela Ottaviani, Manuela Mancini, Claudia Venturi, Cecilia Monaldi, Sara De Santis, Nicoletta Testoni, Simona Soverini, Gianantonio Rosti, Michele Cavo, Fausto Castagnetti
Publikováno v:
Cells, Vol 12, Iss 13, p 1703 (2023)
The introduction of tyrosine kinase inhibitors (TKIs) has changed the treatment paradigm of chronic myeloid leukemia (CML), leading to a dramatic improvement of the outcome of CML patients, who now have a nearly normal life expectancy and, in some se
Externí odkaz:
https://doaj.org/article/664fdd7e85ad4784a4379cfac3a95011
Autor:
Gabriele Gugliotta, Fausto Castagnetti, Massimo Breccia, Luciano Levato, Tamara Intermesoli, Mariella D'Adda, Marzia Salvucci, Fabio Stagno, Giovanna Rege-Cambrin, Mario Tiribelli, Bruno Martino, Monica Bocchia, Michele Cedrone, Elena Trabacchi, Francesco Cavazzini, Ferdinando Porretto, Federica Sorà, Maria Pina Simula, Francesco Albano, Simona Soverini, Robin Foà, Fabrizio Pane, Michele Cavo, Giuseppe Saglio, Michele Baccarani, Gianantonio Rosti
Publikováno v:
Haematologica, Vol 107, Iss 10 (2022)
We report the final analysis, with a 10-year follow-up, of the phase II study GIMEMA CML 0307 (NCT 00481052), which enrolled 73 adult patients (median age 51 years; range, 18-83) with newly diagnosed chronic-phase chronic myeloid leukemia to investig
Externí odkaz:
https://doaj.org/article/a405282ce52c4b72b65440d9cc8fad84
Autor:
Simona Soverini, Francesco Albano, Renato Bassan, Francesco Fabbiano, Felicetto Ferrara, Robin Foà, Attilio Olivieri, Alessandro Rambaldi, Giuseppe Rossi, Simona Sica, Giorgina Specchia, Adriano Venditti, Giovanni Barosi, Fabrizio Pane
Publikováno v:
Cancer Medicine, Vol 9, Iss 9, Pp 2960-2970 (2020)
Abstract Emergence of clones carrying point mutations in the BCR‐ABL1 kinase domain (KD) is a common mechanism of resistance to tyrosine kinase inhibitor (TKI)‐based therapies in Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukem
Externí odkaz:
https://doaj.org/article/20b77fb1e1774c0094c2c846f52e0309
Autor:
Michele Baccarani, Elisabetta Abruzzese, Vincenzo Accurso, Francesco Albano, Mario Annunziata, Sara Barulli, Germana Beltrami, Micaela Bergamaschi, Gianni Binotto, Monica Bocchia, Giovanni Caocci, Isabella Capodanno, Francesco Cavazzini, Michele Cedrone, Marco Cerrano, Monica Crugnola, Mariella D'Adda, Chiara Elena, Carmen Fava, Paola Fazi, Claudio Fozza, Sara Galimberti, Valentina Giai, Antonella Gozzini, Gabriele Gugliotta, Alessandra Iurlo, Gaetano La Barba, Luciano Levato, Alessandro Lucchesi, Luigia Luciano, Francesca Lunghi, Monia Lunghi, Michele Malagola, Roberto Marasca, Bruno Martino, Angela Melpignano, Maria Cristina Miggiano, Enrico Montefusco, Caterina Musolino, Fausto Palmieri, Patrizia Pregno, Davide Rapezzi, Giovanna Rege-Cambrin, Serena Rupoli, Marzia Salvucci, Rosaria Sancetta, Simona Sica, Raffaele Spadano, Fabio Stagno, Mario Tiribelli, Simona Tomassetti, Elena Trabacchi, Massimiliano Bonifacio, Massimo Breccia, Fausto Castagnetti, Fabrizio Pane, Domenico Russo, Giuseppe Saglio, Simona Soverini, Paolo Vigneri, Gianantonio Rosti
Publikováno v:
Blood Advances, Vol 3, Iss 24, Pp 4280-4290 (2019)
Abstract: Several papers authored by international experts have proposed recommendations on the management of BCR-ABL1+ chronic myeloid leukemia (CML). Following these recommendations, survival of CML patients has become very close to normal. The nex
Externí odkaz:
https://doaj.org/article/c710c460a6544522bacd81c73ccaef18
Autor:
Simona Soverini, Elisabetta Abruzzese, Monica Bocchia, Massimiliano Bonifacio, Sara Galimberti, Antonella Gozzini, Alessandra Iurlo, Luigiana Luciano, Patrizia Pregno, Gianantonio Rosti, Giuseppe Saglio, Fabio Stagno, Mario Tiribelli, Paolo Vigneri, Giovanni Barosi, Massimo Breccia
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-11 (2019)
Abstract BCR-ABL1 kinase domain (KD) mutation status is considered to be an important element of clinical decision algorithms for chronic myeloid leukemia (CML) patients who do not achieve an optimal response to tyrosine kinase inhibitors (TKIs). Con
Externí odkaz:
https://doaj.org/article/4a0beae3db7740d48a6fa4a15e2f69bd
Autor:
Samantha Bruno, Lorenza Bandini, Agnese Patuelli, Valentina Robustelli, Claudia Venturi, Manuela Mancini, Dorian Forte, Sara De Santis, Cecilia Monaldi, Alessandra Grassi, Gabriella Chiurumbolo, Stefania Paolini, Gianluca Cristiano, Cristina Papayannidis, Chiara Sartor, Jacopo Nanni, Emanuela Ottaviani, Antonio Curti, Michele Cavo, Simona Soverini
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
FMS-like tyrosine kinase 3 (FLT3) is among the most common driver genes recurrently mutated in acute myeloid leukemia (AML), accounting for approximately 30% of cases. Activating mutations of the FLT3 receptor include internal tandem duplications (IT
Externí odkaz:
https://doaj.org/article/6bb2e31dbe434e4abe6e84f55b172a07