Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Simona Scheggi"'
Autor:
Simona Scheggi
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/2bafde5231134ea9b265c77044974db4
Publikováno v:
Children, Vol 11, Iss 7, p 801 (2024)
Treating depression in adolescents is a significant challenge, and major depressive disorder (MDD) with suicidal ideation and treatment-resistant depression (TRD) are common and potentially devastating to optimal psychological and physical developmen
Externí odkaz:
https://doaj.org/article/03060603b1444e0b86a8e08e41c60b51
Publikováno v:
Brain Research Bulletin, Vol 181, Iss , Pp 157-166 (2022)
Pramipexole is a potent agonist of D3 and D2 dopamine receptors, currently approved for clinical use in Parkinson's disease (PD) and restless leg syndrome. Several studies have shown that pramipexole significantly increases the risk of pathological g
Externí odkaz:
https://doaj.org/article/2a03e2daf6574d92985d4c7d6e23ef3b
Autor:
Roberto Cadeddu, Laura J. Mosher, Peter Nordkild, Nilesh Gaikwad, Gian Michele Ratto, Simona Scheggi, Marco Bortolato
Publikováno v:
Neurobiology of Stress, Vol 21, Iss , Pp 100489- (2022)
Ample evidence indicates that environmental stress impairs information processing, yet the underlying mechanisms remain partially elusive. We showed that, in several rodent models of psychopathology, the neurosteroid allopregnanolone (AP) reduces the
Externí odkaz:
https://doaj.org/article/7e1fbafd22394e87911b45dfff50ad67
Autor:
Simona Scheggi, Francesca Guzzi, Giulia Braccagni, Maria Graziella De Montis, Marco Parenti, Carla Gambarana
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-17 (2020)
Abstract Background The social motivational theory of autism spectrum disorder (ASD) focuses on social anhedonia as key causal feature of the impaired peer relationships that characterize ASD patients. ASD prevalence is higher in boys, but increasing
Externí odkaz:
https://doaj.org/article/904d214b6b8c423888e3b56c8620c773
Autor:
Silvia Fanni, Simona Scheggi, Francesca Rossi, Elisabetta Tronci, Francesco Traccis, Roberto Stancampiano, Maria Graziella De Montis, Paola Devoto, Carla Gambarana, Marco Bortolato, Roberto Frau, Manolo Carta
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 120-130 (2019)
Although 1-3,4-dihydroxyphenylalanine (L-DOPA) is the mainstay therapy for treating Parkinson's disease (PD), its long-term administration is accompanied by the development of motor complications, particularly L-DOPA induced dyskinesia (LID), that dr
Externí odkaz:
https://doaj.org/article/19a02c63148348009be80a883732b055
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 723 (2022)
Peroxisome proliferator-activator receptors (PPARs) regulate lipid and glucose metabolism, control inflammatory processes, and modulate several brain functions. Three PPAR isoforms have been identified, PPARα, PPARβ/δ, and PPARγ, which are expres
Externí odkaz:
https://doaj.org/article/4f45694635de43fc882f100b6043c7c3
Autor:
Simona Scheggi, Teresa Pelliccia, Alessandro Cuomo, Maria Graziella De Montis, Carla Gambarana
Publikováno v:
Heliyon, Vol 4, Iss 10, Pp e00849- (2018)
Background: The antiepileptic lamotrigine is approved for maintenance treatment of bipolar disorder and augmentation therapy in treatment-resistant depression. Previous preclinical investigations showed lamotrigine antidepressant-like effects without
Externí odkaz:
https://doaj.org/article/799b9afa1612435ca20731498fd829d9
Autor:
Sean C. Godar, Roberto Cadeddu, Gabriele Floris, Laura J. Mosher, Zhen Mi, David P. Jarmolowicz, Simona Scheggi, Alicia A. Walf, Carolyn J. Koonce, Cheryl A. Frye, Nancy A. Muma, Marco Bortolato
Publikováno v:
Biomolecules, Vol 9, Iss 11, p 749 (2019)
Finasteride (FIN) is the prototypical inhibitor of steroid 5α-reductase (5αR), the enzyme that catalyzes the rate-limiting step of the conversion of progesterone and testosterone into their main neuroactive metabolites. FIN is clinically approved f
Externí odkaz:
https://doaj.org/article/baf95fecf4604756a46e4525aef8e736
Autor:
Monica Puligheddu, Giuliano Pillolla, Miriam Melis, Salvatore Lecca, Francesco Marrosu, Maria Graziella De Montis, Simona Scheggi, Gianfranca Carta, Elisabetta Murru, Sonia Aroni, Anna Lisa Muntoni, Marco Pistis
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64541 (2013)
Nicotinic acetylcholine receptors (nAChRs) are involved in seizure mechanisms. Hence, nocturnal frontal lobe epilepsy was the first idiopathic epilepsy linked with specific mutations in α4 or β2 nAChR subunit genes. These mutations confer gain of f
Externí odkaz:
https://doaj.org/article/1dbc15029d9a4fd188a75a6d01878efa