Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Simona Saponara"'
Autor:
Iris C. Salaroglio, Denitsa Stefanova, Ricardo G. Teixeira, Nuno F.B. Oliveira, Amer Ahmed, Fabio Fusi, Virginia Tzankova, Yordan Yordanov, Miguel Machuqueiro, Simona Saponara, Andreia Valente, Chiara Riganti
Publikováno v:
Pharmacological Research, Vol 208, Iss , Pp 107353- (2024)
The therapeutic approach to many solid tumors, including non-small cell lung cancer (NSCLC), is mainly based on the use of platinum-containing anticancer agents and is often characterized by acquired or intrinsic resistance to the drug. Therefore, th
Externí odkaz:
https://doaj.org/article/2f88abcebe004d218abfc467fccfd25d
Publikováno v:
Cells, Vol 13, Iss 9, p 788 (2024)
Norbormide (NRB) is a Rattus-selective toxicant, which was serendipitously discovered in 1964 and formerly marketed as an eco-friendly rodenticide that was deemed harmless to non-Rattus species. However, due to inconsistent efficacy and the emergence
Externí odkaz:
https://doaj.org/article/2b3f345730c942bf805c26147ebad733
Autor:
Michele De Luca, Donatella Restuccia, Umile Gianfranco Spizzirri, Pasquale Crupi, Giuseppina Ioele, Beatrice Gorelli, Maria Lisa Clodoveo, Simona Saponara, Francesca Aiello
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 622 (2023)
An ultrasound-assisted extraction method, employing ethanol and water as solvents at low temperature (30 °C) and reduced time (15 min), was proposed to extract bioactive molecules from different cultivars (Magliocco Canino, Magliocco Rosato, Gagliop
Externí odkaz:
https://doaj.org/article/ff0056aee311471da52fea595a048868
Autor:
Petko Alov, Merilin Al Sharif, Denitsa Aluani, Konstantin Chegaev, Jelena Dinic, Aleksandra Divac Rankov, Miguel X. Fernandes, Fabio Fusi, Alfonso T. García-Sosa, Risto Juvonen, Magdalena Kondeva-Burdina, José M. Padrón, Ilza Pajeva, Tania Pencheva, Adrián Puerta, Hannu Raunio, Chiara Riganti, Ivanka Tsakovska, Virginia Tzankova, Yordan Yordanov, Simona Saponara
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Sdox is a hydrogen sulfide (H2S)-releasing doxorubicin effective in P-glycoprotein-overexpressing/doxorubicin-resistant tumor models and not cytotoxic, as the parental drug, in H9c2 cardiomyocytes. The aim of this study was the assessment of Sdox dru
Externí odkaz:
https://doaj.org/article/1c7deddbd8504d1eb6e324f730103fb1
Autor:
Antonella Brizzi, Alfonso Trezza, Ottavia Spiga, Samuele Maramai, Francesco Scorzelli, Simona Saponara, Fabio Fusi
Publikováno v:
Molbank, Vol 2021, Iss 3, p M1258 (2021)
Quercetin and ferulic acid are two phytochemicals extensively represented in the plant kingdom and daily consumed in considerable amounts through diets. Due to a common phenolic structure, these two molecules share several pharmacological properties,
Externí odkaz:
https://doaj.org/article/ab69e5e920104c85a6d78050eab183a2
Autor:
Gabriele Carullo, Miriam Durante, Fabio Sciubba, Donatella Restuccia, Umile Gianfranco Spizzirri, Amer Ahmed, Maria Enrica Di Cocco, Simona Saponara, Francesca Aiello, Fabio Fusi
Publikováno v:
Journal of Functional Foods, Vol 57, Iss , Pp 328-334 (2019)
The valorisation of agrochemical wastes has become a low cost and sustainable tendency for the development of functional food. In particular, these enriched products seem to be enjoyable tools to treat metabolic disorders. In this field, Calabrian au
Externí odkaz:
https://doaj.org/article/33c08c324e5146a7ae1cb55b6e2d1cd7
Autor:
Gabriele Carullo, Simona Saponara, Amer Ahmed, Beatrice Gorelli, Sarah Mazzotta, Alfonso Trezza, Beatrice Gianibbi, Giuseppe Campiani, Fabio Fusi, Francesca Aiello
Publikováno v:
Marine Drugs, Vol 20, Iss 8, p 515 (2022)
Sesquiterpenes such as leucodin and the labdane-type diterpene manool are natural compounds endowed with remarkably in vitro vasorelaxant and in vivo hypotensive activities. Given their structural similarity with the sesquiterpene lactone (+)-sclareo
Externí odkaz:
https://doaj.org/article/6344eb9bf13548c9bf987bc885a2082f
Autor:
Nguyen Manh Cuong, Ninh The Son, Ngu Truong Nhan, Yoshiyasu Fukuyama, Amer Ahmed, Simona Saponara, Alfonso Trezza, Beatrice Gianibbi, Ginevra Vigni, Ottavia Spiga, Fabio Fusi
Publikováno v:
Molecules, Vol 27, Iss 14, p 4505 (2022)
Hypertension is a risk factor for cardiovascular diseases, which are the main cause of morbidity and mortality in the world. In the search for new molecules capable of targeting KCa1.1 and CaV1.2 channels, the expression of which is altered in hypert
Externí odkaz:
https://doaj.org/article/6ac52d15917d45bd936f5b683677d6d7
Autor:
Federica Pessina, Maria Frosini, Paola Marcolongo, Fabio Fusi, Simona Saponara, Alessandra Gamberucci, Massimo Valoti, Daniela Giustarini, Paolo Fiorenzani, Beatrice Gorelli, Valeria Francardi, Maurizio Botta, Elena Dreassi
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233788 (2020)
In pre-hypertension, moderate control of blood pressure (BP) can be obtained by a nutritional approach. The effects of a diet enriched with defatted larvae of the mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) (TM) endowed with ACE inhibitory
Externí odkaz:
https://doaj.org/article/78375ad41d2d45c0a1fc0791bda3cd5a
Autor:
Simona Saponara, Fabio Fusi, Ottavia Spiga, Alfonso Trezza, Brian Hopkins, Margaret A. Brimble, David Rennison, Sergio Bova
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Norbormide is a toxicant selective for rats to which it induces a widespread vasoconstriction. In a recent paper, we hypothesized a role of ATP-sensitive potassium (KATP) channels in norbormide-induced vasoconstriction. The current study was undertak
Externí odkaz:
https://doaj.org/article/18a6532a8e3a4071a230dd2aad61c3f4