Výsledky vyhledávání - "Simona S. Ghanem"

Akademický článek

Screening for Novel Inhibitors of Amyloid Beta Aggregation and Toxicity as Potential Drugs for Alzheimer’s Disease

Autor: Sanaa Sharari, Nishant N. Vaikath, Magdalini Tsakou, Simona S. Ghanem, Kostas Vekrellis

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 14, p 11326 (2023)

AD is the most common neurodegenerative disorder characterized by progressive memory impairment and cognitive deficits. The pathology of AD is still unclear; however, several studies have shown that the aggregation of the Aβ peptide in the CNS is an

Externí odkaz: https://doaj.org/article/8ff04f73f0cd482595ebcada4910615d

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Autor: Ilham Y. Abdi, Simona S. Ghanem, Omar M. El-Agnaf

Publikováno v: Neurobiology of Disease, Vol 170, Iss , Pp 105771- (2022)

Despite the increasing number of studies on Parkinson's disease and it being the second most common neurodegenerative disorder in the world, no established diagnostic markers or disease modifying therapies are available. Understanding the mechanisms

Externí odkaz: https://doaj.org/article/b8a8c9e0cc10421a860d41d07ba8f3ed

Zobrazit plný text záznamu

Akademický článek

Rapid Assessment of CRISPR Transfection Efficiency and Enrichment of CRISPR Induced Mutations Using a Dual-Fluorescent Stable Reporter System

Autor: Karim E. Shalaby, Mustapha Aouida, Vijay Gupta, Simona S. Ghanem, Omar M. A. El-Agnaf

Publikováno v: Frontiers in Genome Editing, Vol 4 (2022)

The nuclease activity of the CRISPR-Cas9 system relies on the delivery of a CRISPR-associated protein 9 (Cas9) and a single guide RNA (sgRNA) against the target gene. CRISPR components are typically delivered to cells as either a Cas9/sgRNA ribonucle

Externí odkaz: https://doaj.org/article/c2a184203bee41af960b1c1a28b923a2

Zobrazit plný text záznamu

Akademický článek

Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts

Autor: Mustafa T. Ardah, Simona S. Ghanem, Sara A. Abdulla, Guohua Lv, Mohamed M. Emara, Katerina E. Paleologou, Nishant N. Vaikath, Jia-Hong Lu, Min Li, Konstantinos Vekrellis, David Eliezer, Omar M. A. El-Agnaf

Publikováno v: BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-21 (2020)

Abstract Background Recent studies indicated that seeded fibril formation and toxicity of α-synuclein (α-syn) play a main role in the pathogenesis of certain diseases including Parkinson’s disease (PD), multiple system atrophy, and dementia with

Externí odkaz: https://doaj.org/article/20d1bd5274794f01b0343a5862a81e46

Zobrazit plný text záznamu

Akademický článek

Nicotinamide Mononucleotide Prevents Free Fatty Acid-Induced Reduction in Glucose Tolerance by Decreasing Insulin Clearance

Autor: Ashraf Nahle, Yemisi Deborah Joseph, Sandra Pereira, Yusaku Mori, Frankie Poon, Hilda E. Ghadieh, Aleksandar Ivovic, Tejas Desai, Simona S. Ghanem, Suman Asalla, Harrison T. Muturi, Emelien M. Jentz, Jamie W. Joseph, Sonia M. Najjar, Adria Giacca

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 24, p 13224 (2021)

The NAD-dependent deacetylase SIRT1 improves β cell function. Accordingly, nicotinamide mononucleotide (NMN), the product of the rate-limiting step in NAD synthesis, prevents β cell dysfunction and glucose intolerance in mice fed a high-fat diet. T

Externí odkaz: https://doaj.org/article/f88ba7de538c4a80adcd7d91c2eaac40

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity

Autor: Simona S. Ghanem, Hend S. Fayed, Qi Zhu, Jia-Hong Lu, Nishant N. Vaikath, Janarthanan Ponraj, Said Mansour, Omar M. A. El-Agnaf

Publikováno v: Molecules, Vol 26, Iss 12, p 3736 (2021)

The accumulation and aggregation of α-synuclein (α-syn) is the main pathologic event in Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy. α-Syn-seeded fibril formation and its induced toxicity occupy a major role

Externí odkaz: https://doaj.org/article/340f359f92b643dab08028d648431a56

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis[S]

Autor: Lucia Russo, Hilda E. Ghadieh, Simona S. Ghanem, Qusai Y. Al-Share, Zachary N. Smiley, Cara Gatto-Weis, Emily L. Esakov, Marcia F. McInerney, Garrett Heinrich, Xin Tong, Lei Yin, Sonia M. Najjar

Publikováno v: Journal of Lipid Research, Vol 57, Iss 12, Pp 2163-2175 (2016)

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin sensitivity by promoting hepatic insulin clearance and mediating suppression of fatty acid synthase activity. Feeding C57BL/6J male mice with a high-fat (HF) diet f

Externí odkaz: https://doaj.org/article/f7f6fe2e102a48d98a2c1e9bb9c83e65

Zobrazit plný text záznamu

Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein Fibrils

Autor: Issam Hmila, Indulekha P. Sudhakaran, Simona S. Ghanem, Nishant N. Vaikath, Ilaria Poggiolini, Houari Abdesselem, Omar M. A. El-Agnaf

Publikováno v: ACS chemical neuroscience. 13(23)

Neuropathologically, Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by the accumulation of insoluble aggregates of α-synuclein (α-syn) in the Lewy bodies (LBs). In addition to full-length α-syn fibrils, C-terminally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a33fbddc835d011eda25b8cd6ae3a1d
https://pubmed.ncbi.nlm.nih.gov/36348612

Zobrazit plný text záznamu

Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity

Autor: Issam Hmila, Nishant N. Vaikath, Nour K. Majbour, Daniel Erskine, Indulekha P. Sudhakaran, Vijay Gupta, Simona S. Ghanem, Zeyaul Islam, Mohamed M. Emara, Houari B. Abdesselem, Prasanna R. Kolatkar, Devaya K. Achappa, Tatiana Vinardell, Omar M. A. El‐Agnaf

Nanobodies (Nbs), the single-domain antigen-binding fragments of dromedary heavy-chain antibodies (HCAb), are excellent candidates as therapeutic and diagnostic tools in synucleinopathies because of their small size, solubility and stability. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7afe0faf6d6d61b614b545270062368
https://hdl.handle.net/10576/45151

Zobrazit plný text záznamu

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity

Publikováno v: Ghanem, S S, Majbour, N K, Vaikath, N N, Ardah, M T, Erskine, D, Jensen, N M, Fayyad, M, Sudhakaran, I P, Vasili, E, Melachroinou, K, Abdi, I Y, Poggiolini, I, Santos, P, Dorn, A, Carloni, P, Vekrellis, K, Attems, J, McKeith, I, Outeiro, T F, Jensen, P H & El-Agnaf, O M A 2022, ' α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity ', PNAS (Proceedings of the National Academy of Sciences of the United States of America), vol. 119, no. 15, e2109617119 . https://doi.org/10.1073/pnas.2109617119
Proceedings of the National Academy of Sciences of the United States of America 119(15), e2109617119 (2022). doi:10.1073/pnas.2109617119

α-Synuclein (α-syn) phosphorylation at serine 129 (pS129–α-syn) is substantially increased in Lewy body disease, such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). However, the pathogenic relevance of pS129–α-syn remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba55d29b3d2b2ef5284fe1134f6d0e19
https://doi.org/10.1073/pnas.2109617119

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání