PGE2 Is Crucial for the Generation of FAST Whole- Tumor-Antigens Loaded Dendritic Cells Suitable for Immunotherapy in Glioblastoma

Autor: Sara Nava, Daniela Lisini, Simona Frigerio, Simona Pogliani, Serena Pellegatta, Laura Gatti, Gaetano Finocchiaro, Anna Bersano, Eugenio Agostino Parati

Publikováno v: Pharmaceutics, Vol 12, Iss 3, p 215 (2020)

Dendritic cells (DC) are the most potent antigen-presenting cells, strongly inducers of T cell-mediated immune responses and, as such, broadly used as vaccine adjuvant in experimental clinical settings. DC are widely generated from human monocytes fo

Externí odkaz: https://doaj.org/article/673bf26dde334825b20098d77ad28e94

Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial

Autor: Silvia Lanfranconi, Elisa Scola, Jennifer M T A Meessen, Roberto Pallini, Giulio A Bertani, Rustam Al-Shahi Salman, Elisabetta Dejana, Roberto Latini, Giorgia Abete Fornara, Nicolò M. Agnelli, Alessio Albanese, Issam Awad, Renzo Bagnati, Giovanna Balconi, Elena Ballabio, Ettore Beghi, Roberto Bernasconi, Giulio A. Bertani, Silvia Besana, Adriana Blanda, Chiara Bossi, Nereo Bresolin, Maria G. Buratti, Roberta Calabrese, Maria R. Carriero, Marco Castori, Elisa F. Ciceri, Rossella Ciurleo, Giacomo P. Comi, Valeria Contarino, Giorgio Conte, Leonardo D'Agruma, Giorgio Q. D'Alessandris, Ugo de Grazia, Rina Di Bonaventura, Piergiorgio d'Orio, Giuseppe Farago', Andreana Foresta, Carmela Fusco, Chiara Gaudino, Maria G. Lampugnani, Alessia Lanno, Francesca Lazzaroni, Cornelia Lee, Marco Locatelli, Aldo P. Maggioni, Peetra Magnusson, Matteo Malinverno, Maurizio Mangiavacchi, Antonella Mangraviti, Silvia Marino, Selene Mazzola, Enrico B. Nicolis, Deborah Novelli, Maria L. Ojeda Fernandez, Antonio Petracca, Fabrizio Pignotti, Simona Pogliani, Marco Poloni, Alessandro Prelle, Pamela Raggi, Franca Raucci, Caroline Regna-Gladin, Dario Ronchi, Emma Scelzo, Salim Seyfried, Anna Simeone, Carmelo L. Sturiale, Laura Tassi, Mauro Tettamanti, Valter Torri, Elisabeth Tournier-Lasserve, Rita Treglia, Fabio M. Triulzi, Celeste Ungaro, Elison Ursi, Gloria Valcamonica, Antonella Vasami', Barbara Zarino

Publikováno v: 2022, ' Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM) : a randomised, open-label, blinded-endpoint, phase 2 pilot trial ', Lancet Neurology, vol. 22, no. 1, pp. 35-44 . https://doi.org/10.1016/S1474-4422(22)00409-4

BACKGROUND: Observations in people with cerebral cavernous malformations, and in preclinical models of this disorder, suggest that the β-blocker propranolol might reduce the risk of intracerebral haemorrhage. We aimed to evaluate the safety and effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf849e3941f72e0e818d389cb7c8c758
https://doi.org/10.1016/s1474-4422(22)00409-4

Stem Cell Production: Processes, Practices, and Regulation

Autor: Daniela Lisini, Simona Frigerio, Sara Nava, Simona Pogliani

Publikováno v: Stem Cell Production ISBN: 9789811675881

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::103d0c704f5d0b3657b424fc236b492f
https://doi.org/10.1007/978-981-16-7589-8_6

PGE2 Is Crucial for the Generation of FAST Whole- Tumor-Antigens Loaded Dendritic Cells Suitable for Immunotherapy in Glioblastoma

Autor: Gaetano Finocchiaro, Simona Pogliani, Simona Frigerio, Daniela Lisini, Sara Nava, Laura Gatti, Anna Bersano, Eugenio Parati, Serena Pellegatta

Publikováno v: Pharmaceutics, Vol 12, Iss 3, p 215 (2020)
Pharmaceutics
Volume 12
Issue 3

Dendritic cells (DC) are the most potent antigen-presenting cells, strongly inducers of T cell-mediated immune responses and, as such, broadly used as vaccine adjuvant in experimental clinical settings. DC are widely generated from human monocytes fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558d345f1f22cfa704562f7baa8221dd
https://www.mdpi.com/1999-4923/12/3/215

Safe and Reproducible Preparation of Functional Dendritic Cells for Immunotherapy in Glioblastoma Patients

Autor: Simona Frigerio, Daniela Lisini, Gaetano Finocchiaro, Sara Nava, Anna Bersano, Simona Pogliani, Eugenio Parati, Marta Dossena, Serena Pellegatta

Publikováno v: Stem cells translational medicine. 4(10)

Cell therapy based on dendritic cells (DCs) pulsed with tumor lysate is a promising approach in addition to conventional therapy for the treatment of patients with glioblastoma (GB). The success of this approach strongly depends on the ability to gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32235d3c8bf3a320a262644dffcd127b
https://pubmed.ncbi.nlm.nih.gov/26273063