Barrel cortex development lacks a key stage of hyperconnectivity from deep to superficial layers in a rat model of Absence Epilepsy

Autor: Simona Plutino, Emel Laghouati, Guillaume Jarre, Antoine Depaulis, Isabelle Guillemain, Ingrid Bureau

The development of cortical neuronal wiring is precisely orchestrated and goes through several stages, some of which coincide with critical periods when sensory experience is most influential. In particular, although ascending excitatory and inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4db387cce49339a2fa758abaff855b9
https://doi.org/10.1101/2022.03.18.484944

Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for α4β2 nACh receptors

Autor: Cecilia Gotti, Gérard Aimé Pinna, Miriam Sciaccaluga, Gabriele Murineddu, Francesca Fasoli, Giovanni Loriga, Simona Plutino, Sergio Fucile, Francesco Deligia, Giulio Ragusa, Battistina Asproni

Publikováno v: European journal of medicinal chemistry 152 (2018): 401–416. doi:10.1016/j.ejmech.2018.04.026
info:cnr-pdr/source/autori:Deligia, F.; Murineddu, G.; Gotti, C.; Ragusa, G.; Fasoli, F.; Sciaccaluga, M.; Plutino, S.; Fucile, S.; Loriga, G.; Asproni, B.; Pinna, G. A./titolo:Pyridinyl-and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for ?4<%2Finf>?2<%2Finf>nACh receptors/doi:10.1016%2Fj.ejmech.2018.04.026/rivista:European journal of medicinal chemistry/anno:2018/pagina_da:401/pagina_a:416/intervallo_pagine:401–416/volume:152

The cholinergic pathways in the central nervous system (CNS) of animals and humans are important for cognitive and behavioural functions. Until a few years ago, it was thought that the key molecules transducing the cholinergic message were the metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da655537ee6484da71bef676693dd02
https://doi.org/10.1016/j.ejmech.2018.04.026

Extracellular mild acidosis decreases the Ca 2+ permeability of the human NMDA receptors

Autor: Simona Plutino, Sergio Fucile, Miriam Sciaccaluga

NMDA receptors (NMDARs) are glutamate-gated ion channels involved in excitatory synaptic transmission and in others physiological processes such as synaptic plasticity and development. The overload of Ca2+ ions through NMDARs, caused by an excessive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6461038003d84761dcb77764dc922d2b
http://hdl.handle.net/11391/1472445

The fifth subunit in α3β4 nicotinic receptor is more than an accessory subunit

Autor: Marco Righi, Cecilia Gotti, Sara Francesca Colombo, Simona Plutino, Miriam Sciaccaluga, Sergio Fucile, Arianna Crespi, Nica Borgese

The α3β4 subtype is the predominant neuronal nicotinic acetylcholine receptor present in the sensory and autonomic ganglia and in a subpopulation of brain neurons. This subtype can form pentameric receptors with either 2 or 3 β4 subunits that have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1d3d6b6aa08754e9ad03df0a7f39be
http://hdl.handle.net/11573/1141482