Výsledky vyhledávání - "Simona Iezzi"

Akademický článek

Immunotherapy in melanoma: advances, pitfalls, and future perspectives

Autor: Cristina Sorino, Simona Iezzi, Ludovica Ciuffreda, Italia Falcone

Publikováno v: Frontiers in Molecular Biosciences, Vol 11 (2024)

Cutaneous melanoma is the deadliest and most aggressive form of skin cancer owing to its high capacity for metastasis. Over the past few decades, the management of this type of malignancy has undergone a significant revolution with the advent of both

Externí odkaz: https://doaj.org/article/9238a61fdb91425fbe8f88d0e2a82875

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Akademický článek

AATF/Che-1 RNA polymerase II binding protein overexpression reduces the anti-tumor NK-cell cytotoxicity through activating receptors modulation

Autor: Matteo Caforio, Nicola Tumino, Cristina Sorino, Isabella Manni, Stefano Di Giovenale, Giulia Piaggio, Simona Iezzi, Georgios Strimpakos, Elisabetta Mattei, Lorenzo Moretta, M. Fanciulli, Paola Vacca, Franco Locatelli, Valentina Folgiero

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionAATF/Che-1 over-expression in different tumors is well known and its effect on tumorigenicity is mainly due to its central role demonstrated in the oncogenic pathways of solid tumors, where it controls proliferation and viability. The eff

Externí odkaz: https://doaj.org/article/f5115f9bf1b74bdf9a69050d6bb081ea

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Akademický článek

On the Role of Seismic Damage Tolerance on Costs and Life Cycle of CLT Buildings

Autor: Simona Iezzi, Francesca Savini, Ilaria Trizio, Giovanni Fabbrocino, Antonio Sandoli

Publikováno v: Applied Sciences, Vol 13, Iss 16, p 9113 (2023)

This paper presents a contribution to reviewing the most common seismic design procedures of CLT buildings and their implications on structural features and technological solutions. Attention is particularly focused on the overall seismic performance

Externí odkaz: https://doaj.org/article/2ce3d198d3e1416c828e2ab888f942bf

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Akademický článek

CK2-mediated phosphorylation of Che-1/AATF is required for its pro-proliferative activity

Autor: Valeria Catena, Tiziana Bruno, Simona Iezzi, Silvia Matteoni, Annalisa Salis, Cristina Sorino, Gianluca Damonte, Maurizio Fanciulli

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)

Abstract Background Che-1/AATF (Che-1) is an RNA polymerase II binding protein involved in several cellular processes, including proliferation, apoptosis and response to stress. We have recently demonstrated that Che-1 is able to promote cell prolife

Externí odkaz: https://doaj.org/article/6e94d75d1af74a768388bda796916ded

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HAX1 Is a Novel Binding Partner of Che-1/AATF. Implications in Oxidative Stress Cell Response

Autor: Cinzia Pisani, Annalisa Onori, Francesca Gabanella, Simona Iezzi, Roberta De Angelis, Maurizio Fanciulli, Andrea Colizza, Marco De Vincentiis, Maria Grazia Di Certo, Claudio Passananti, Nicoletta Corbi

HAX1 is a multifunctional protein involved in the antagonism of apoptosis in cellular response to oxidative stress. In the present study we identified HAX1 as novel binding partner for Che-1/AATF, a pro-survival factor which plays a crucial role in f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101bdc10e3617ce2883911a92eaf5b75
https://doi.org/10.20944/preprints202302.0287.v1

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Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma

Publikováno v: Blood Adv
Blood advances 4 (2020): 5616–5630. doi:10.1182/bloodadvances.2020002566
info:cnr-pdr/source/autori:Tiziana Bruno 1, Francesca De Nicola 1, Giacomo Corleone 1, Valeria Catena 1, Frauke Goeman 1, Matteo Pallocca 1, Cristina Sorino 1, Gianluca Bossi 2, Bruno Amadio 1, Giovanni Cigliana 3, Maria Rosaria Ricciardi 4, Maria Teresa Petrucci 5, Enrico Pierluigi Spugnini 1, Alfonso Baldi 6, Mario Cioce 2, Giancarlo Cortese 1, Elisabetta Mattei 7, Roberta Merola 3, Umberto Gianelli 8, Luca Baldini 8, Francesco Pisani 9, Svitlana Gumenyuk 9, Andrea Mengarelli 9, Katja Höpker 10, Thomas Benzing 10 11 12, Bruno Vincenzi 13, Aristide Floridi 1, Claudio Passananti 14, Giovanni Blandino 2, Simona Iezzi 1, Maurizio Fanciulli 1/titolo:Che-1%2FAATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma/doi:10.1182%2Fbloodadvances.2020002566/rivista:Blood advances/anno:2020/pagina_da:5616/pagina_a:5630/intervallo_pagine:5616–5630/volume:4

Multiple myeloma (MM) is a hematologic malignancy produced by a clonal expansion of plasma cells and characterized by abnormal production and secretion of monoclonal antibodies. This pathology exhibits an enormous heterogeneity resulting not only fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1af284419cc671558000110b541c9b
http://hdl.handle.net/11591/438908

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CK2-mediated phosphorylation of Che-1/AATF is required for its pro-proliferative activity

Autor: Silvia Matteoni, Cristina Sorino, Tiziana Bruno, Valeria Catena, Maurizio Fanciulli, Gianluca Damonte, Simona Iezzi, Annalisa Salis

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)

Background Che-1/AATF (Che-1) is an RNA polymerase II binding protein involved in several cellular processes, including proliferation, apoptosis and response to stress. We have recently demonstrated that Che-1 is able to promote cell proliferation by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea659c20ebecc2c41c11f14fc0170220
https://doi.org/10.1186/s13046-021-02038-x

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