Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha‐1‐anti‐trypsin deficiency

Autor: Nunzia Pastore, Keith Blomenkamp, Fabio Annunziata, Pasquale Piccolo, Pratibha Mithbaokar, Rosa Maria Sepe, Francesco Vetrini, Donna Palmer, Philip Ng, Elena Polishchuk, Simona Iacobacci, Roman Polishchuk, Jeffrey Teckman, Andrea Ballabio, Nicola Brunetti‐Pierri

Publikováno v: EMBO Molecular Medicine, Vol 5, Iss 3, Pp 397-412 (2013)

Abstract Alpha‐1‐anti‐trypsin deficiency is the most common genetic cause of liver disease in children and liver transplantation is currently the only available treatment. Enhancement of liver autophagy increases degradation of mutant, hepatoto

Externí odkaz: https://doaj.org/article/f439b5daf4144d6699e801b90df4847d

Uroplakin traffic through the Golgi apparatus induces its fragmentation: new insights from novel in vitro models

Autor: Giancarlo Chesi, Mateja Erdani Kreft, Rok Romih, Roman S. Polishchuk, Nataša Resnik, Tanja Višnjar, Marko Kreft, Simona Iacobacci, Horst Robenek, Elena Polishchuk

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)

Uroplakins (UPs) play an essential role in maintaining an effective urothelial permeability barrier at the level of superficial urothelial cell (UC) layer. Although the organization of UPs in the apical plasma membrane (PM) of UCs is well known, thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8bcbe2bda4295134162f876f3333d3
http://europepmc.org/articles/PMC5634464

Identification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutants

Autor: Giancarlo Chesi, 1 Ramanath N. Hegde, 2, + Simona Iacobacci, 1, + Mafalda Concilli, + Seetharaman Parashuraman, 2 Beatrice Paola Festa, 1 Elena V. Polishchuk, 1 Giuseppe Di Tullio, 1 Annamaria Carissimo, 1 Sandro Montefusco, 1 Diana Canetti, 3 Maria Monti, 3 Angela Amoresano, 3 Piero Pucci, 3 Bart van de Sluis, 4 Svetlana Lutsenko, 5 Alberto Luini, corresponding author 2, 6, Roman S. Polishchukcorresponding author 1

Publikováno v: Hepatology (Baltim. Md. : Online) (2016).
info:cnr-pdr/source/autori:Giancarlo Chesi, 1 Ramanath N. Hegde, 2, + Simona Iacobacci, 1, + Mafalda Concilli, 1, + Seetharaman Parashuraman, 2 Beatrice Paola Festa, 1 Elena V. Polishchuk, 1 Giuseppe Di Tullio, 1 Annamaria Carissimo, 1 Sandro Montefusco, 1 Diana Canetti, 3 Maria Monti, 3 Angela Amoresano, 3 Piero Pucci, 3 Bart van de Sluis, 4 Svetlana Lutsenko, 5 Alberto Luini,corresponding author 2, 6, ? and Roman S. Polishchukcorresponding author 1, ?/titolo:Identification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutants/doi:/rivista:Hepatology (Baltim. Md. : Online)/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume

Wilson disease (WD) is an autosomal recessive disorder that is caused by the toxic accumulation of copper (Cu) in the liver. The ATP7B gene, which is mutated in WD, encodes a multitransmembrane domain adenosine triphosphatase that traffics from the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::3bc4f2fe42d7092c88c09f41fd2354d2
https://publications.cnr.it/doc/365907

Identification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutants

Autor: Alberto Luini, Giancarlo Chesi, Annamaria Carissimo, Diana Canetti, Piero Pucci, Mafalda Concilli, Simona Iacobacci, Maria Chiara Monti, Elena V. Polishchuk, Seetharaman Parashuraman, Roman S. Polishchuk, Giuseppe Di Tullio, Angela Amoresano, Bart van de Sluis, Sandro Montefusco, Svetlana Lutsenko, Ramanath Narayana Hegde, Beatrice Paola Festa

Publikováno v: Hepatology, 63(6), 1842-1859. Wiley
Hepatology (Baltimore, Md.)
Hepatology (Baltim. Md. : Online) (2015). doi:10.1002/hep.28398
info:cnr-pdr/source/autori:Chesi G, Hegde RN, Iacobacci S, Concilli M, Parashuraman S, Festa BP, Polishchuk EV, Di Tullio G, Carissimo A, Montefusco S, Canetti D, Monti M, Amoresano A, Pucci P, van de Sluis B, Lutsenko S, Luini A, Polishchuk RS/titolo:Identification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutants./doi:10.1002%2Fhep.28398/rivista:Hepatology (Baltim. Md. : Online)/anno:2015/pagina_da:/pagina_a:/intervallo_pagine:/volume

UNLABELLED Wilson disease (WD) is an autosomal recessive disorder that is caused by the toxic accumulation of copper (Cu) in the liver. The ATP7B gene, which is mutated in WD, encodes a multitransmembrane domain adenosine triphosphatase that traffics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44258bdc0f95ee9bf3dca8869aec015b
https://pubmed.ncbi.nlm.nih.gov/26822144

Cytosolic phospholipase A2ε drives recycling in the clathrin-independent endocytic route

Autor: Cristiano Iurisci, Giuseppe Di Tullio, Mariagrazia Capestrano, Alessio Di Pentima, Mikhail V. Egorov, Stefania Mariggiò, Roberto Buccione, Anastasia V. Egorova, Giuseppe Perinetti, Michele Santoro, Alberto Luini, Simona Iacobacci, Roman S. Polishchuk

Publikováno v: Journal of Cell Science.

Previous studies have demonstrated that membrane tubule-mediated transport events in biosynthetic and endocytic routes require phospholipase A 2 (PLA 2 ) activity. Here, we show that cytosolic phospholipase A 2 e (cPLA 2 e, also known as PLA2G4E) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::788efa4ef461fc3031f375b3cf41e9d5
https://doi.org/10.1242/jcs.136598