Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Simona Hankeová"'
Autor:
Jan Mašek, Iva Filipovic, Noémi Van Hul, Lenka Belicová, Markéta Jiroušková, Daniel V Oliveira, Anna Maria Frontino, Simona Hankeova, Jingyan He, Fabio Turetti, Afshan Iqbal, Igor Červenka, Lenka Sarnová, Elisabeth Verboven, Tomáš Brabec, Niklas K Björkström, Martin Gregor, Jan Dobeš, Emma R Andersson
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 11, Pp 2946-2975 (2024)
Abstract Fibrosis contributes to tissue repair, but excessive fibrosis disrupts organ function. Alagille syndrome (ALGS, caused by mutations in JAGGED1) results in liver disease and characteristic fibrosis. Here, we show that Jag1 Ndr/Ndr mice, a mod
Externí odkaz:
https://doaj.org/article/d566732a6e3740f0b6a4cbf98781c57c
Autor:
Simona Hankeova, Noemi Van Hul, Jakub Laznovsky, Elisabeth Verboven, Katrin Mangold, Naomi Hensens, Csaba Adori, Elvira Verhoef, Tomas Zikmund, Feven Dawit, Michaela Kavkova, Jakub Salplachta, Marika Sjöqvist, Bengt R Johansson, Mohamed G Hassan, Linda Fredriksson, Karsten Baumgärtel, Vitezslav Bryja, Urban Lendahl, Andrew Jheon, Florian Alten, Kristina Teär Fahnehjelm, Björn Fischler, Jozef Kaiser, Emma R Andersson
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 12, Pp 1-23 (2022)
Abstract Spontaneous bleeds are a leading cause of death in the pediatric JAG1‐related liver disease Alagille syndrome (ALGS). We asked whether there are sex differences in bleeding events in patients, whether Jag1Ndr/Ndr mice display bleeds or vas
Externí odkaz:
https://doaj.org/article/06eb0c1933c14c07a0211bd34884636e
Autor:
Simona Hankeova, Jakub Salplachta, Tomas Zikmund, Michaela Kavkova, Noémi Van Hul, Adam Brinek, Veronika Smekalova, Jakub Laznovsky, Feven Dawit, Josef Jaros, Vítězslav Bryja, Urban Lendahl, Ewa Ellis, Antal Nemeth, Björn Fischler, Edouard Hannezo, Jozef Kaiser, Emma Rachel Andersson
Publikováno v:
eLife, Vol 10 (2021)
Organ function depends on tissues adopting the correct architecture. However, insights into organ architecture are currently hampered by an absence of standardized quantitative 3D analysis. We aimed to develop a robust technology to visualize, digita
Externí odkaz:
https://doaj.org/article/b15a162506be45549627228691187bdb
Autor:
Nuria Oliva-Vilarnau, Simona Hankeova, Sabine U. Vorrink, Souren Mkrtchian, Emma R. Andersson, Volker M. Lauschke
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
The liver fulfills central roles in metabolic control and detoxification and, as such, is continuously exposed to a plethora of insults. Importantly, the liver has a unique ability to regenerate and can completely recoup from most acute, non-iterativ
Externí odkaz:
https://doaj.org/article/cb56e87cde7d42f3b68f0c76263d91bd
Autor:
Jan Mašek, Iva Filipovic, Simona Hankeová, Jingyan He, Noémi Van Hul, Lenka Belicová, Markéta Jiroušková, Anna Maria Frontino, Fabio Turetti, Daniel V. Oliveira, Igor Červenka, Lenka Sarnová, Elisabeth Verboven, Tomáš Brabec, Niklas K. Björkström, Martin Gregor, Jan Dobeš, Emma R. Andersson
Background and AimsAlagille syndrome (ALGS) is a pediatric genetic disorder, caused by mutations in the Notch ligandJAGGED1, presenting with cholestasis due to intrahepatic bile duct paucity. Despite chronic liver disease, few patients develop severe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc08b5a7d9c962c5cff658d615563084
https://doi.org/10.1101/2022.10.24.513578
https://doi.org/10.1101/2022.10.24.513578
Publikováno v:
Oncology. 82:114-118
Objectives: The development of colorectal cancer (CRC) is characterized by multiple genetic alterations. Transcribed ultraconserved regions (T-UCRs) are a subset of 481 sequenc es longer than 200 bp, which are absolutely conserved between orthologous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2691bec33bb0f0085a9feea8856ed83d
https://doi.org/10.1159/000336479
https://doi.org/10.1159/000336479
Autor:
Jiri Sana, Simona Hankeová, Rostislav Vyzula, Radek Lakomy, Marian Hajduch, Jaroslav Michálek, Martin Smrčka, Leos Kren, Ondrej Slaby, Pavel Fadrus, Hana Dolezelova, Eva Lzicarova, Marek Svoboda
Publikováno v:
Cancer Science. 102:2186-2190
Glioblastoma multiforme (GBM) is the most frequently occurring primary malignant brain tumor; patients with GBM often have a very poor prognosis and differing responses to treatment. Therefore, it is very important to find new biomarkers that can pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a780c130db1678ceb9764fdfb888a9d
https://doi.org/10.1111/j.1349-7006.2011.02092.x
https://doi.org/10.1111/j.1349-7006.2011.02092.x