Výsledky vyhledávání - "Simona Guazzone"

Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload

Autor: Roberta Poulet, Giuseppe Lembo, Luigi Fratta, Antonella Notte, Simona Guazzone, Emilio Hirsch, Guido Tarone, Marika De Acetis, Gennaro Marino, Fiorella Altruda, Carmine Vecchione, Lorenzo Silengo, Mara Brancaccio

Publikováno v: Nature medicine. 9(1)

Cardiac hypertrophy is an adaptive response to a variety of mechanical and hormonal stimuli, and represents an early event in the clinical course leading to heart failure. By gene inactivation, we demonstrate here a crucial role of melusin, a muscle-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b6eb28bd7c3c1c131ff73efd1ca167
https://pubmed.ncbi.nlm.nih.gov/12514714

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The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading

Autor: Fiorella Balzac, Guido Tarone, Mara Brancaccio, Simona Degani, Alessandra Eva, Saverio Francesco Retta, Lorenzo Silengo, Simona Guazzone

Publikováno v: The Journal of Cell Biology

Using two-hybrid screening, we isolated the integrin cytoplasmic domain-associated protein (ICAP-1), an interactor for the COOH terminal region of the β1A integrin cytoplasmic domain. To investigate the role of ICAP-1 in integrin-mediated adhesive f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c4fcd3d11da5ed7bd951ef217b0139
https://pubmed.ncbi.nlm.nih.gov/11807099

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Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain

Autor: Marco De Andrea, Nadia Menini, Fiorella Altruda, Lorenzo Silengo, Elena Sibona, Guido Tarone, Mariano Rocchi, Emilio Hirsch, Simona Guazzone, Mara Brancaccio

Here we describe the isolation and partial characterization of a new muscle-specific protein (Melusin) which interacts with the integrin cytoplasmic domain. The cDNA encoding Melusin was isolated in a two-hybrid screening of a rat neonatal heart libr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de42fa2347989f86445cbf4be65bc96
http://hdl.handle.net/2318/39062

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Role of citron kinase in dendritic morphogenesis of cortical neurons

Autor: Ferdinando Di Cunto, Sara Imarisio, Roberta Curtetti, Vania Broccoli, Fiorella Altruda, Simona Guazzone, Alessandro Vercelli, Alessandro Bulfone, Lorenzo Silengo, Luciana Ferrara

Publikováno v: Europe PubMed Central

Small GTPases of the rho family regulate the extensive rearrangements of the cytoskeleton that characterize neuronal differentiation. Citron kinase is a target molecule for activated rhoA, previously implicated in control of cytokinesis. We have foun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03733cb598688b2782f635b7bde3aaa1
http://europepmc.org/abstract/med/12781320

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