Proteomics reveals specific biological changes induced by the normothermic machine perfusion of donor kidneys with a significant up-regulation of Latexin

Autor: Gianluigi Zaza, Flavia Neri, Maurizio Bruschi, Simona Granata, Andrea Petretto, Martina Bartolucci, Caterina di Bella, Giovanni Candiano, Giovanni Stallone, Loreto Gesualdo, Lucrezia Furian

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Renal normothermic machine perfusion (NMP) is an organ preservation method based on the circulation of a warm (35–37 °C) perfusion solution through the renal vasculature to deliver oxygen and nutrients. However, its biological effects on

Externí odkaz: https://doaj.org/article/e6d3eef848204a26b15801e1a7ed5878

mTOR-inhibitors and post-transplant diabetes mellitus: a link still debated in kidney transplantation

Autor: Simona Granata, Silvia Mercuri, Dario Troise, Loreto Gesualdo, Giovanni Stallone, Gianluigi Zaza

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

The mammalian target of rapamycin inhibitors (mTOR-Is, Sirolimus, and Everolimus) are immunosuppressive drugs widely employed in kidney transplantation. Their main mechanism of action includes the inhibition of a serine/threonine kinase with a pivota

Externí odkaz: https://doaj.org/article/265301a1841b4c9a9468282d6a65973e

Proteomic profile of mesothelial exosomes isolated from peritoneal dialysis effluent of children with focal segmental glomerulosclerosis

Autor: Maurizio Bruschi, Edoardo La Porta, Isabella Panfoli, Giovanni Candiano, Andrea Petretto, Enrico Vidal, Xhuliana Kajana, Martina Bartolucci, Simona Granata, Gian Marco Ghiggeri, Gianluigi Zaza, Enrico Verrina

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)

Abstract Peritoneal dialysis (PD) is the worldwide recognized preferred dialysis treatment for children affected by end-stage kidney disease (ESKD). However, due to the unphysiological composition of PD fluids, the peritoneal membrane (PM) of these p

Externí odkaz: https://doaj.org/article/668de2919f1b4a5b9c47b3293609cb21

Proteomics insights into medullary sponge kidney (MSK) disease: review of the recent results of an Italian research collaborative network.

Autor: Simona Granata, Maurizio Bruschi, Giovanni Candiano, Valeria Catalano, Gian Marco Ghiggeri, Giovanni Stallone, Gianluigi Zaza

Publikováno v: Kidney & Blood Pressure Research (2022)

Background: Medullary sponge kidney (MSK) disease is a rare and neglected congenital condition typically associated with nephrocalcinosis/nephrolithiasis, urinary concentration defects and cystic anomalies in the precalyceal ducts that, although spor

Externí odkaz: https://doaj.org/article/b5184fdc2e8e47e98f33c934a5add908

The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis

Autor: Jingyuan Xie, Lili Liu, Nikol Mladkova, Yifu Li, Hong Ren, Weiming Wang, Zhao Cui, Li Lin, Xiaofan Hu, Xialian Yu, Jing Xu, Gang Liu, Yasar Caliskan, Carlo Sidore, Olivia Balderes, Raphael J. Rosen, Monica Bodria, Francesca Zanoni, Jun Y. Zhang, Priya Krithivasan, Karla Mehl, Maddalena Marasa, Atlas Khan, Fatih Ozay, Pietro A. Canetta, Andrew S. Bomback, Gerald B. Appel, Simone Sanna-Cherchi, Matthew G. Sampson, Laura H. Mariani, Agnieszka Perkowska-Ptasinska, Magdalena Durlik, Krzysztof Mucha, Barbara Moszczuk, Bartosz Foroncewicz, Leszek Pączek, Ireneusz Habura, Elisabet Ars, Jose Ballarin, Laila-Yasmin Mani, Bruno Vogt, Savas Ozturk, Abdülmecit Yildiz, Nurhan Seyahi, Hakki Arikan, Mehmet Koc, Taner Basturk, Gonca Karahan, Sebahat Usta Akgul, Mehmet Sukru Sever, Dan Zhang, Domenico Santoro, Mario Bonomini, Francesco Londrino, Loreto Gesualdo, Jana Reiterova, Vladimir Tesar, Claudia Izzi, Silvana Savoldi, Donatella Spotti, Carmelita Marcantoni, Piergiorgio Messa, Marco Galliani, Dario Roccatello, Simona Granata, Gianluigi Zaza, Francesca Lugani, GianMarco Ghiggeri, Isabella Pisani, Landino Allegri, Ben Sprangers, Jin-Ho Park, BeLong Cho, Yon Su Kim, Dong Ki Kim, Hitoshi Suzuki, Antonio Amoroso, Daniel C. Cattran, Fernando C. Fervenza, Antonello Pani, Patrick Hamilton, Shelly Harris, Sanjana Gupta, Chris Cheshire, Stephanie Dufek, Naomi Issler, Ruth J. Pepper, John Connolly, Stephen Powis, Detlef Bockenhauer, Horia C. Stanescu, Neil Ashman, Ruth J. F. Loos, Eimear E. Kenny, Matthias Wuttke, Kai-Uwe Eckardt, Anna Köttgen, Julia M. Hofstra, Marieke J. H. Coenen, Lambertus A. Kiemeney, Shreeram Akilesh, Matthias Kretzler, Lawrence H. Beck, Benedicte Stengel, Hanna Debiec, Pierre Ronco, Jack F. M. Wetzels, Magdalena Zoledziewska, Francesco Cucca, Iuliana Ionita-Laza, Hajeong Lee, Elion Hoxha, Rolf A. K. Stahl, Paul Brenchley, Francesco Scolari, Ming-hui Zhao, Ali G. Gharavi, Robert Kleta, Nan Chen, Krzysztof Kiryluk

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

Membranous nephropathy (MN) is a rare autoimmune disease of podocyte-directed antibodies, such as anti-phospholipase A2 receptor. Here, the authors report a genome-wide association study for MN and identify two previously unreported loci encompassing

Externí odkaz: https://doaj.org/article/673c37d7cf9b414b91486e389bd81da8